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Bethyl Laboratories
Paf1 Polyclonal Antibody
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Product Details
A300-173A
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residues 475 and 525 of human RNA Polymerase Associated Factor.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
phosphate/tris citrate, pH 7-8
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
Target Information
This gene encodes a subunit of the polymerase associated factor (PAF1) complex. The PAF1 complex interacts with RNA polymerase II and plays a role in transcription elongation as well as histone modifications including ubiquitylation and methylation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: hPAF1; Paf1, RNA polymerase II associated factor, homolog; Pancreatic differentiation protein 2; RNA polymerase II-associated factor 1 homolog
Gene Aliases: 5730511K23Rik; AA675045; F23149_1; PAF1; PD2
UniProt ID: (Human) Q8N7H5, (Mouse) Q8K2T8
Entrez Gene ID: (Human) 54623, (Mouse) 54624
negative regulation of transcription from RNA polymerase II promoter
endodermal cell fate commitment
transcription, DNA-templated
regulation of transcription, DNA-templated
mRNA polyadenylation
histone monoubiquitination
Wnt signaling pathway
nucleosome positioning
stem cell population maintenance
positive regulation of histone methylation
positive regulation of mRNA 3'-end processing
positive regulation of transcription elongation from RNA polymerase II promoter
histone H2B ubiquitination
protein localization to nucleus
negative regulation of myeloid cell differentiation
positive regulation of transcription from RNA polymerase II promoter
cellular response to lipopolysaccharide
transcription elongation from RNA polymerase II promoter
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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