NeoBiotechnologies

Pancreatic duodenal homeobox-1 protein (PDX1) Monoclonal Antibody (PCRP-PDX1-2C11)

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

3651-MSM1-P1ABX

Applications
Tested Dilution
Publications

Immunocytochemistry (ICC/IF)

1-2 µg/mL
-

Flow Cytometry (Flow)

1-2 µg/10^6 cells
-

Peptide Array (Array)

Assay-dependent
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG2c

Class

Monoclonal

Type

Antibody

Clone

PCRP-PDX1-2C11

Immunogen

Recombinant full-length human PDX1 protein
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A/G

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20°C or -80°C if preferred

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

The protein encoded by this gene is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. The encoded nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in this gene are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (NIDDM), as well as maturity onset diabetes of the young type 4 (MODY4).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: DLDBP; E3BP; Glucose-sensitive factor; GSF; IDX-1; Insulin promoter factor 1; insulin promoter factor 1, homeodomain transcription factor; Insulin upstream factor 1; IPF-1; Islet/duodenum homeobox-1; IUF-1; Pancreas/duodenum homeobox protein 1; pancreatic-duodenal homeobox factor 1; PDHX; PDX-1; somatostatin transcription factor 1; Somatostatin-transactivating factor 1; STF-1

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Gene Aliases: GSF; IDX-1; IPF1; IUF1; MODY4; PAGEN1; PDX-1; PDX1; STF-1; STF1

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UniProt ID: (Human) P52945

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Entrez Gene ID: (Human) 3651

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Function(s)
RNA polymerase II core promoter proximal region sequence-specific DNA binding core promoter sequence-specific DNA binding chromatin binding transcription factor activity, sequence-specific DNA binding transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding transcription factor binding protein complex binding protein heterodimerization activity
Process(es)
negative regulation of transcription from RNA polymerase II promoter liver development type B pancreatic cell differentiation glucose metabolic process generation of precursor metabolites and energy transcription from RNA polymerase II promoter smoothened signaling pathway nitric oxide mediated signal transduction central nervous system development positive regulation of cell proliferation negative regulation of cell proliferation response to wounding organ morphogenesis response to iron(II) ion response to chlorate organ senescence positive regulation of cell death morphogenesis of embryonic epithelium insulin secretion exocrine pancreas development organ regeneration response to vitamin response to cytokine response to nicotine positive regulation of insulin secretion involved in cellular response to glucose stimulus response to drug glucose homeostasis response to leucine positive regulation of DNA binding positive regulation of transcription from RNA polymerase II promoter digestive tract development stem cell differentiation response to glucocorticoid detection of glucose transdifferentiation response to fatty acid negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway negative regulation of type B pancreatic cell apoptotic process
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