Parkin Recombinant Rabbit Monoclonal Antibody (JF82-09)

transcription regulatory region sequence-specific DNA binding G-protein coupled receptor binding transcription factor activity, sequence-specific DNA binding actin binding ubiquitin-protein transferase activity protein binding beta-catenin binding zinc ion binding tubulin binding ligase activity SH3 domain binding enzyme binding kinase binding protein kinase binding PDZ domain binding Hsp70 protein binding heat shock protein binding ubiquitin conjugating enzyme binding ubiquitin protein ligase binding identical protein binding histone deacetylase binding ubiquitin binding phospholipase binding chaperone binding ubiquitin protein ligase activity cullin family protein binding ubiquitin protein ligase activity involved in ERAD pathway ubiquitin-specific protease binding F-box domain binding protein complex binding UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity ribosomal S6-glutamic acid ligase activity coenzyme F420-0 gamma-glutamyl ligase activity coenzyme F420-2 alpha-glutamyl ligase activity metal ion binding protein-glycine ligase activity protein-glycine ligase activity, initiating protein-glycine ligase activity, elongating tubulin-glycine ligase activity protein-glutamic acid ligase activity tubulin-glutamic acid ligase activity

protein polyubiquitination mitochondrial fission mitophagy negative regulation of protein phosphorylation synaptic transmission, dopaminergic startle response transcription, DNA-templated cellular protein modification process ubiquitin-dependent protein catabolic process protein monoubiquitination response to oxidative stress response to unfolded protein mitochondrion organization learning locomotory behavior adult locomotory behavior regulation of autophagy positive regulation of mitochondrial fusion negative regulation of mitochondrial fusion regulation of mitochondrion organization protein ubiquitination protein metabolic process regulation of protein ubiquitination negative regulation of actin filament bundle assembly positive regulation of proteasomal ubiquitin-dependent protein catabolic process negative regulation of glucokinase activity response to endoplasmic reticulum stress synaptic transmission, glutamatergic norepinephrine metabolic process dopamine metabolic process response to drug neuron maturation protein ubiquitination involved in ubiquitin-dependent protein catabolic process positive regulation of I-kappaB kinase/NF-kappaB signaling proteasome-mediated ubiquitin-dependent protein catabolic process positive regulation of DNA binding negative regulation of neuron apoptotic process cellular protein catabolic process negative regulation by host of viral genome replication positive regulation of transcription from RNA polymerase II promoter negative regulation of JNK cascade negative regulation of insulin secretion regulation of neurotransmitter secretion modulation of synaptic transmission protein stabilization regulation of protein transport response to corticosterone dopamine uptake involved in synaptic transmission mitochondrion localization protein autoubiquitination zinc ion homeostasis negative regulation of cell death neuron cellular homeostasis protein K63-linked ubiquitination protein localization to mitochondrion aggresome assembly protein K48-linked ubiquitination positive regulation of mitochondrial fission negative regulation of release of cytochrome c from mitochondria cellular response to toxic substance regulation of cellular response to oxidative stress negative regulation of neuron death positive regulation of proteasomal protein catabolic process negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway positive regulation of protein linear polyubiquitination negative regulation of oxidative stress-induced neuron death positive regulation of tumor necrosis factor-mediated signaling pathway negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway regulation of reactive oxygen species metabolic process negative regulation of reactive oxygen species metabolic process negative regulation of transcription from RNA polymerase II promoter central nervous system development proteasomal protein catabolic process positive regulation of gene expression negative regulation of gene expression regulation of glucose metabolic process free ubiquitin chain polymerization regulation of dopamine secretion macroautophagy protein destabilization regulation of lipid transport cellular response to unfolded protein protein K29-linked ubiquitination ERAD pathway regulation of dopamine metabolic process cellular protein metabolic process protein K27-linked ubiquitination positive regulation of protein catabolic process positive regulation of neurotransmitter uptake regulation of mitochondrial membrane potential regulation of canonical Wnt signaling pathway parkin-mediated mitophagy in response to mitochondrial depolarization protein K11-linked ubiquitination cellular response to manganese ion protein K6-linked ubiquitination negative regulation of canonical Wnt signaling pathway mitophagy in response to mitochondrial depolarization negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator negative regulation of primary amine oxidase activity regulation of synaptic vesicle transport negative regulation of oxidative stress-induced cell death regulation of protein targeting to mitochondrion cellular response to dopamine positive regulation of dendrite extension negative regulation of spontaneous neurotransmitter secretion regulation of transcription, DNA-templated autophagy