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Invitrogen
Pericentrin Polyclonal Antibody
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FIGURE: 1 / 11
Pericentrin Antibody (PA5-115736) in ICC/IF
Immunofluorescence analysis of Pericentrin was performed using 70% confluent log phase HEK-293 cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 15 minutes, and blocked with 2% BSA for 1 hour at room temperature. The cells were labeled with Pericentrin Polyclonal Antibody (Product # PA5-115736) at 1:100 in 0.1% BSA, incubated at 4 degree celsius o... View More
Product Details
PA5-115736
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human PCNT(Accession O95613), corresponding to amino acid residues L3269-G3319.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2900371
Product Specific Information
Antibody detects endogenous levels of total Pericentrin - Centrosome Marker.
Target Information
This gene encodes a protein that was identified in a screen for genes expressed in metastatic cells, specifically, mammary adenocarcinoma cell lines. Expression of this gene has been correlated with the metastatic potential of at least two types of carcinomas although it is also expressed in many normal tissues. The role it plays in metastasis is unclear. It was initially thought to be the 70kD component of a nucleosome remodeling deacetylase complex, NuRD, but it is more likely that this component is a different but very similar protein. These two proteins are so closely related, though, that they share the same types of domains. These domains include two DNA binding domains, a dimerization domain, and a domain commonly found in proteins that methylate DNA. The profile and activity of this gene product suggest that it is involved in regulating transcription and that this may be accomplished by chromatin remodeling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Kendrin; Pericentrin; pericentrin 2; pericentrin-2; pericentrin-250; pericentrin-360; pericentrin-380; Pericentrin-B
Gene Aliases: AW476095; C86676; KEN; kendrin; KIAA0402; m239Asp; m275Asp; MOPD2; PCN; PCNT; PCNT2; PCNTB; PCTN2; SCKL4
UniProt ID: (Human) O95613, (Mouse) P48725
Entrez Gene ID: (Human) 5116, (Mouse) 18541, (Rat) 309692
in utero embryonic development
neuron migration
spindle organization
cerebellar cortex morphogenesis
olfactory bulb development
limb morphogenesis
multicellular organism growth
cilium assembly
negative regulation of apoptotic process
brain morphogenesis
neural precursor cell proliferation
G2/M transition of mitotic cell cycle
microtubule cytoskeleton organization
mitotic spindle organization
positive regulation of intracellular protein transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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