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Invitrogen
Perilipin 1 Polyclonal Antibody, Alexa Fluor™ 555
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FIGURE: 1 / 1
Perilipin 1 Antibody (PA1-1051-A555) in ICC/IF
Immunofluorescent analysis of Perilipin (red) in HepG2 cells. The cells were fixed with 4% Paraformaldehyde for 15 minutes, permeabilized with 0.1% Triton X-100 for 15 minutes, and blocked with 5% BSA for 30 minutes at room temperature. Cells were stained with a Perilipin rabbit polyclonal antibody (Product # PA1-1051-A555) at a concentration of 5 µg/mL in blocking buffer for 1 hour at room temperature. Nuc... View More
Product Details
PA1-1051-A555
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to the residues C E(502) P I L G R T Q Y S Q L R K K S(517) of rat Perilipin A.
Conjugate
Excitation/Emission Max
553/568 nm
View spectra
Form
Liquid
Concentration
1.0 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with 1.0mg/mL BSA
Contains
0.05% sodium azide
Storage conditions
4°C, store in dark, DO NOT FREEZE!
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2723454
Product Specific Information
PA1-1051 detects perilipin A from rat and 3T3-L1 cell extract. The PA1-1051 immunogen is a synthetic peptide corresponding to the residues C E(502) P I L G R T Q Y S Q L R K K S(517) of rat Perilipin A. This sequence is 93% conserved in humans. The PA1-1051 immunizing peptide (Cat. # PEP-169) is available for use in neutralization and control experiments.
Target Information
Adipose tissue is an energy reserve in animals and is strictly regulated in nondomestic species. Adipose cells produce and secrete numerous physiologically important proteins, such as lipoprotein lipase (LPL), leptin, adipocyte complement related protein of 30 kDa (Acrp30), resistin, and perilipin. Perilipin is an intracellular neutral lipid droplet protein that is hormonally regulated. This protein is localized exclusively to the surface of lipid droplets. In response to lypotic stimuli, perilipin is phosphorylated by protein kinase A. Once activated, perilipin has inhibitory affects upon hormone-sensitive lipase (HSL), a protein that mediates the hydrolysis of triacylglycerol, the major form of stored energy in the body. Perilipin expression is limited to adipocytes and steroidogenic cells. There are currently two known isoforms, Perilipin A and B. Both of these proteins are encoded by a single-copy gene and are the result of differential splicing events.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Lipid droplet-associated protein; PERI; perilipin; Perilipin A; perilipin B; Perilipin-1
Gene Aliases: 6030432J05Rik; Peri; PERIA; Plin; Plin1
UniProt ID: (Mouse) Q8CGN5
Entrez Gene ID: (Mouse) 103968, (Rat) 25629
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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