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Invitrogen
Phospho-AKT1 (Thr342) Polyclonal Antibody
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FIGURE: 1 / 2
Phospho-AKT1 (Thr342) Antibody (PA5-95669) in WB
Western blot of AKT1 in Drosophila lysate showing specific labeling of the ~68 kDa corresponding to Phospho-AKT1 (Thr342) polyclonal antibody (Product # PA5-95669) in the first lane (-). Phosphospecificity is shown in the second lane (+) where the immunolabeling is completely eliminated by blot treatment with lambda phosphatase (1,200 units for 30 minutes).
Product Details
PA5-95669
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Fruit fly
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic phospho-peptide corresponding to amino acid residues surrounding Thr342 conjugated to KLH
Conjugate
Form
Liquid
Concentration
0.25 mg/mL
Purification
Antigen Affinity Chromatography
Storage buffer
10mM HEPES, pH 7.5, with 100µg/mL BSA, 50% glycerol, 0.15M NaCl
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2807471
Product Specific Information
Antigen Affinity Purified from Pooled Serum
Target Information
AKT1 (PKB alpha) is a serine/threonine kinase that regulates cell survival. The activated enzyme inhibits apoptosis and stimulates cell cycle progression by phosphorylating numerous targets in various cell types, including cancer cells. This protein kinase is activated by insulin, PI3K, IGF1 and various other growth and survival factors. Akt promotes cell survival by inhibiting apoptosis through phosphorylation and inactivation of several targets, including forkhead transcription factors, and caspase-9. The AKT pathway is a major target for cancer drug discovery.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Akt kinase; Akt1; Akt1-PA; Akt1-PB; Akt1-PC; Akt1-PD; Akt1-PE; C-AKT; CAKT; CG4006-PA; CG4006-PB; CG4006-PC; CG4006-PD; CG4006-PE; DAkt; dAkt kinase; PKB; PKB beta; PKB gamma; PKBG; Protein kinase B; RAC serine/threonine-protein kinase; RAC-PK-beta; RAC-PK-gamma; related to PKA to PKC protein kinases; related to the A and C kinases
Gene Aliases: AKT; AKT/PKB; AKT1; Akt1|PKB; CG4006; D-Akt; DAkt; dAKT/dPKB; dAkt/PKB; DAKT1; DAKT1/PKB; Dmel\CG4006; Dmel_CG4006; DPKB; DRAC-PK; DRAC-PK66; DRAC-PK85; l(3)04226; l(3)89Bq; p-Akt; pAkt; PKB; PKB/AKT; PKB/dAKT; RAC; RacPK
UniProt ID: (Fruit fly) Q8INB9
Entrez Gene ID: (Fruit fly) 41957
protein phosphorylation
lipid metabolic process
response to oxidative stress
open tracheal system development
epithelial cell migration, open tracheal system
myoblast fusion
somatic muscle development
circadian rhythm
insulin receptor signaling pathway
regulation of cell shape
regulation of cell size
chitin-based embryonic cuticle biosynthetic process
regulation of glucose metabolic process
lipid storage
positive regulation of cell growth
dendrite regeneration
regulation of hemocyte proliferation
multicellular organism growth
intracellular signal transduction
regulation of multicellular organism growth
positive regulation of multicellular organism growth
regulation of protein import into nucleus
negative regulation of apoptotic process
positive regulation of cell size
negative regulation of synaptic growth at neuromuscular junction
regulation of organ growth
positive regulation of organ growth
oogenesis
positive regulation of axon regeneration
regulation of dendrite development
long term synaptic depression
negative regulation of peptide hormone secretion
negative regulation of neuron death
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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