Invitrogen

Phospho-AMPK alpha-1 (Ser496) Recombinant Rabbit Monoclonal Antibody (7N4C7)

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

MA5-35855

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Mouse

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

7N4C7

Immunogen

A synthetic phosphorylated peptide around S496 of human AMPKalpha1 (Q13131)
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.36 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol, 0.05% BSA

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2849753

Product Specific Information

Immunogen sequence: SGSVS

Target Information

Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: 5'-AMP-activated protein kinase catalytic subunit alpha-1; AAPK2; ACACA kinase; Acetyl-CoA carboxylase kinase; activated protein kinase; AMP activated protein kinase; AMP-activated protein kinase, alpha 1 catalytic subunit; AMPK subunit alpha-1; AMPK subunit pAMPK; AMPK-alpha-2 chain; AMPK2; HMGCR kinase; Hydroxymethylglutaryl-CoA reductase kinase; MGC33776; MGC57364; pAMPK; PRKAA; PRKAA2; Tau-protein kinase PRKAA1

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Gene Aliases: AI194361; AI450832; AL024255; AMPKalpha1; C130083N04Rik; Prkaa1

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UniProt ID: (Mouse) Q5EG47

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Entrez Gene ID: (Mouse) 105787

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Function(s)
nucleotide binding chromatin binding protein kinase activity protein serine/threonine kinase activity AMP-activated protein kinase activity protein binding ATP binding protein C-terminus binding kinase activity transferase activity transferase activity, transferring phosphorus-containing groups kinase binding histone serine kinase activity metal ion binding [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity tau-protein kinase activity [acetyl-CoA carboxylase] kinase activity
Process(es)
activation of MAPK activity glucose metabolic process transcription, DNA-templated regulation of transcription, DNA-templated protein phosphorylation lipid metabolic process fatty acid metabolic process fatty acid biosynthetic process steroid biosynthetic process cholesterol biosynthetic process autophagy steroid metabolic process cholesterol metabolic process positive regulation of cell proliferation lipid biosynthetic process response to UV cold acclimation response to gamma radiation positive regulation of autophagy positive regulation of gene expression response to activity Wnt signaling pathway sterol biosynthetic process phosphorylation chromatin modification fatty acid oxidation response to caffeine cellular response to nutrient levels negative regulation of TOR signaling regulation of peptidyl-serine phosphorylation histone-serine phosphorylation intracellular signal transduction cellular response to glucose starvation response to hydrogen peroxide glucose homeostasis regulation of circadian rhythm negative regulation of apoptotic process positive regulation of glycolytic process rhythmic process positive regulation of skeletal muscle tissue development negative regulation of lipid catabolic process protein heterooligomerization fatty acid homeostasis regulation of vesicle-mediated transport cellular response to prostaglandin E stimulus response to camptothecin regulation of energy homeostasis negative regulation of glucose import in response to insulin stimulus
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