Invitrogen

Phospho-Androgen Receptor (Ser213, Ser210) Monoclonal Antibody (156C135.2)

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Datasheet
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Datasheet
Protocols
Questions & Answers

Product Details

MA5-16221

Applications
Tested Dilution
Publications

Western Blot (WB)

1-4 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

1:10-1:500
-
Product Specifications

Species Reactivity

Dog, Human, Mouse, Non-human primate, Rat

Host/Isotype

Mouse / IgG1, kappa

Class

Monoclonal

Type

Antibody

Clone

156C135.2

Immunogen

Synthetic peptide corresponding to amino acids 207-221 (GRAREAS*GAPTSSKD) of human androgen receptor, containing the serine 213 phosphorylation.
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein G

Storage buffer

PBS

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2537739

Product Specific Information

Suggested positive control: IGF-1 stimulated LNCaP.

Target Information

The androgen receptor (AR) is a member of the steroid-hormone receptor superfamily of nuclear receptors. The receptor is more than 90 kDa and has three major functional domains: the N-terminal domain, DNA-binding domain, and the androgen-binding domain. The androgen receptor is a ligand-activated transcription factor that binds active testosterone (T) and dihydrotestosterone (DHT). Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. The AR signaling pathway plays a key role in development and function of male reproductive organs, including the prostate and epididymis. AR also plays a role in nonreproductive organs, such as muscle, hair follicles, and brain. Androgen Receptor is a phosphoprotein, and also regulates mitogen-activated protein kinase (MAP kinase). The inhibition of the MEK1/2 pathway correlates directly with a change in phosphorylation state of the androgen receptor. Abnormalities in the AR signaling pathway have been linked to a number of diseases, including prostate cancer, Kennedy's disease, and male infertility. Mutations in this gene are associated with complete androgen insensitivity (CAIS).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: androgen nuclear receptor variant 2; Androgen receptor; androgen receptor (dihydrotestosterone receptor; testicular feminization; spinal and bulbar muscular atrophy; Kennedy disease); androgen receptor (Testicular feminization), same as Tfm; androgen receptor splice variant 4b; AR-A; Dihydrotestosterone receptor; Nuclear receptor subfamily 3 group C member 4; RP11-383C12.1; Variant AR45

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Gene Aliases: AIS; Andr; AR; AR8; AW320017; DHTR; HUMARA; HYSP1; KD; NR3C4; SBMA; SMAX1; TFM

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UniProt ID: (Human) P10275, (Rat) P15207, (Mouse) P19091

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Entrez Gene ID: (Dog) 403588, (Human) 367, (Rat) 24208, (Mouse) 11835

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Function(s)
transcription factor activity, sequence-specific DNA binding RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding androgen receptor activity androgen binding beta-catenin binding zinc ion binding sequence-specific DNA binding transcription regulatory region DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding RNA polymerase II transcription factor binding DNA binding chromatin binding receptor binding steroid binding protein binding transcription factor binding enzyme binding protein dimerization activity ATPase binding protein domain specific binding androgen receptor binding POU domain binding
Process(es)
transcription, DNA-templated positive regulation of cell proliferation androgen receptor signaling pathway intracellular receptor signaling pathway positive regulation of phosphorylation steroid hormone mediated signaling pathway negative regulation of integrin biosynthetic process positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of NF-kappaB transcription factor activity regulation of establishment of protein localization to plasma membrane negative regulation of extrinsic apoptotic signaling pathway transcription initiation from RNA polymerase II promoter transport signal transduction cell-cell signaling sex differentiation cell proliferation negative regulation of cell proliferation positive regulation of gene expression cell growth prostate gland development positive regulation of cell differentiation positive regulation of integrin biosynthetic process positive regulation of transcription from RNA polymerase III promoter protein oligomerization in utero embryonic development regulation of systemic arterial blood pressure epithelial cell morphogenesis regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter spermatogenesis single fertilization male gonad development fertilization cellular process regulation of gene expression male somatic sex determination response to insulin positive regulation of intracellular estrogen receptor signaling pathway Leydig cell differentiation multicellular organism growth positive regulation of MAPK cascade positive regulation of insulin-like growth factor receptor signaling pathway male sex differentiation reproductive structure development regulation of developmental growth organ formation male genitalia morphogenesis negative regulation of epithelial cell proliferation regulation of catalytic activity activation of prostate induction by androgen receptor signaling pathway morphogenesis of an epithelial fold lateral sprouting involved in mammary gland duct morphogenesis regulation of prostatic bud formation prostate gland growth prostate gland epithelium morphogenesis epithelial cell differentiation involved in prostate gland development tertiary branching involved in mammary gland duct morphogenesis mammary gland alveolus development reproductive system development cellular response to steroid hormone stimulus seminiferous tubule development
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