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Invitrogen
Phospho-Aquaporin 2 (Ser261) Polyclonal Antibody
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FIGURE: 1 / 1
Phospho-Aquaporin 2 (Ser261) Antibody (PA5-106075) in WB
Western blot analysis of Phospho-Aquaporin 2 (Ser261) in A2780 cell lysate (absence (-) or presence (+) of non-phospho and phospho peptide). Samples were incubated with Phospho-Aquaporin 2 (Ser261) polyclonal antibody (Product # PA5-106075).
Product Details
PA5-106075
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human AQP2(Accession P41181), corresponding to amino acid residues around phosphorylated Ser261.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
sequential chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2817474
Product Specific Information
Antibody detects endogenous levels of AQP2 only when phosphorylated at Ser261.
Target Information
Aquaporin 2 (AQP2) is a hormonally regulated water channel located in the renal collecting duct. Mutations in the AQP2 gene cause hereditary nephrogenic diabetes insipidus in humans. A vasopressin induced cAMP increase results in the phosphorylation of AQP2 at serine-256 and its translocation from the intracellular vesicles to the apical membrane of principal cells. Recently, serine-261 has been identified as a novel phosphorylation site on AQP2 and levels of phosphorylated S261 have been shown to decrease with vasopressin treatment suggesting its involvement in vasopressin-dependent AQP2 trafficking.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ADH water channel; AQP 2; AQP CD; AQP-2; AQP-CD; AQPCD; aquaporin 2 (collecting duct); Aquaporin CD; Aquaporin-2; Aquaporin-CD; Aquaporin2; Aquaporine 2; Collecting duct water channel protein; MGC34501; Water channel protein for renal collecting duct; water-channel aquaporin 2; WCH CD; WCH-CD; WCHCD
Gene Aliases: AQP-2; AQP-CD; AQP2; aquaporin-2; cph; jpk; WCH-CD
UniProt ID: (Human) P41181, (Mouse) P56402, (Rat) P34080
Entrez Gene ID: (Human) 359, (Mouse) 11827, (Rat) 25386
renal water homeostasis
renal water transport
water transport
excretion
cellular water homeostasis
glycerol transport
ion transmembrane transport
cellular response to water deprivation
cellular response to copper ion
cellular response to mercury ion
metanephric collecting duct development
transport
cell volume homeostasis
apoptotic process
actin filament depolymerization
carbohydrate transmembrane transport
positive regulation of calcium ion transport
transmembrane transport
hyperosmotic response
female pregnancy
aging
response to water deprivation
response to salt stress
response to hormone
response to lithium ion
water homeostasis
response to lipopolysaccharide
response to glucagon
response to starvation
response to calcium ion
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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