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Invitrogen
Phospho-CDK1 (Tyr15) Monoclonal Antibody (E.658.6)
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Product Details
MA5-15062
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Non-human primate,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Monoclonal
Type
Antibody
Clone
E.658.6
Immunogen
Synthetic phosphopeptide corresponding to residues surrounding pTyr15 of human cdc2
Conjugate
Form
Liquid
Concentration
13 µg/mL
Purification
Affinity chromatography
Storage buffer
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
Contains
<0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_10984869
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
CDK1 or Cell Division Control protein 1 is essential for the completion of START, the controlling event in the cell cycle that is required to initiate mitosis. CDK1 is a catalytic subunit of a protein kinase complex, called the M-Phase Promoting Factor that induces entry into mitosis and is universal among eukaryotes. Phosphorylation of Bcl-2 in G2/M phase-arrested cells following photodynamic therapy with hypericin involves a CDK1-mediated signal and delays the onset of apoptosis. Therapeutic potential of CDK inhibitor NU2058 in androgen-independent prostate cancer has also been demonstrated.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ABL1; CDK1; cell cycle controller CDC2; cell cycle p34 CDC2 kinase protein; Cell division control protein 2 homolog; cell division cycle 2 homolog A; cell division cycle 2, G1 to S and G2 to M; Cell division cycle control protein 2; cell division cycle control protein 2a; Cell division protein kinase 1; Cyclin-dependent kinase 1; DKFZp686L20222; KCIP-1; MGC111195; MGC53829; OTTHUMP00000019660; P34 CDK1; P34 MGC111195; p34 protein kinase; Protein 1054
Gene Aliases:
CDC2; CDC28A; Cdc2a; CDK1; CDKN1; p34
UniProt ID: (Human) P06493, (Rat) P39951, (Mouse) P11440
Entrez Gene ID: (Human) 983, (Rat) 54237, (Mouse) 12534
protein kinase activity
protein serine/threonine kinase activity
cyclin-dependent protein serine/threonine kinase activity
protein binding
ATP binding
RNA polymerase II carboxy-terminal domain kinase activity
cyclin binding
Hsp70 protein binding
histone kinase activity
kinase activity
nucleotide binding
transferase activity
transferase activity, transferring phosphorus-containing groups
mitotic cell cycle
protein complex assembly
protein phosphorylation
apoptotic process
mitotic nuclear division
mitotic G2 DNA damage checkpoint
cell aging
response to toxic substance
response to organonitrogen compound
positive regulation of gene expression
response to organic cyclic compound
response to amine
response to activity
histone phosphorylation
peptidyl-serine phosphorylation
peptidyl-threonine phosphorylation
chromosome condensation
epithelial cell differentiation
organ regeneration
positive regulation of protein import into nucleus, translocation
protein localization to kinetochore
response to drug
response to hydrogen peroxide
negative regulation of apoptotic process
response to ethanol
positive regulation of DNA replication
positive regulation of mitotic cell cycle
response to cadmium ion
response to copper ion
response to axon injury
cell division
ventricular cardiac muscle cell development
positive regulation of cardiac muscle cell proliferation
cellular response to hydrogen peroxide
cell cycle
phosphorylation
G1/S transition of mitotic cell cycle
regulation of transcription involved in G1/S transition of mitotic cell cycle
G2/M transition of mitotic cell cycle
activation of MAPK activity
microtubule cytoskeleton organization
DNA replication
DNA repair
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
mitotic nuclear envelope disassembly
centrosome cycle
pronuclear fusion
regulation of Schwann cell differentiation
cell migration
anaphase-promoting complex-dependent catabolic process
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
proteasome-mediated ubiquitin-dependent protein catabolic process
regulation of embryonic development
negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
Golgi disassembly
positive regulation of protein localization to nucleus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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