Invitrogen

Phospho-CDK2 (Tyr15) Recombinant Rabbit Monoclonal Antibody (HL1474)

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

MA5-50316

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:3,000
-

ELISA (ELISA)

Assay-dependent
-
Product Specifications

Species Reactivity

Fruit fly, Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

HL1474

Immunogen

Carrier-protein conjugated synthetic peptide corresponding to residues around human CDK2 (phospho Tyr15). The exact sequence is proprietary.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

PBS

Contains

no preservative

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_3094391

Target Information

CDK2/cyclinO is a member of the cyclin dependent protein kinase family complexed to CyclinO. CyclinO was used as a specific protein isoform name for the UNG gene which is localized exclusively in the nucleus. In addition, CyclinO was reported to shows significant uracil-DNA glycosylase activity. CDK2/cyclinO protein levels increase during G1 phase and the protein is turned over during the course of cell cycle. The levels of cyclin A-cdk2 is maximal at the G1/S transition and both cdk2 and cyclin A are found associated with DNA in the initiation complex during replication. Rb protein acts as substrate for cdk2-cyclin E and/or cdk2-cyclin A in vivo. Cdk2 is activated and specifically localized to the nucleus during late G1-, S-, and G2-phase.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: cdc2-related protein kinase; CDC28; CDC2A; cdc2c; CDK1; Cdk2-PA; Cdk2-PB; Cdk2-PC; Cell division control protein 2 cognate; Cell division protein kinase 2; CG10498-PA; CG10498-PB; CG10498-PC; cyclin dependent kinase 2-alpha; cyclin E; cyclin E-CDK2; Cyclin-dependent kinase 2; EC 2.7.11.22; EC 2.7.11.23; kinase Cdc2; MPF; p33 protein kinase; p33CDK2; p34 protein kinase

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Gene Aliases: A630093N05Rik; CDC2C; CDK2; CDK2/CDC2c; CDKN2; CG10498; Dcdc2c; dCdk2; DmCdc2; Dmcdc2c; DmCdk2; Dmel\CG10498; Dmel_CG10498; p33(CDK2); S(Sev-CycE)3A

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UniProt ID: (Human) P24941, (Mouse) P97377, (Fruit fly) P23573

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Entrez Gene ID: (Human) 1017, (Rat) 362817, (Mouse) 12566, (Fruit fly) 42453

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Function(s)
protein serine/threonine kinase activity cyclin-dependent protein serine/threonine kinase activity protein binding ATP binding kinase activity cyclin binding protein complex binding histone kinase activity metal ion binding protein kinase activity nucleotide binding transferase activity transferase activity, transferring phosphorus-containing groups
Process(es)
G1/S transition of mitotic cell cycle lens development in camera-type eye DNA repair protein phosphorylation potassium ion transport mitotic nuclear division Ras protein signal transduction positive regulation of cell proliferation response to toxic substance histone phosphorylation peptidyl-serine phosphorylation organ regeneration positive regulation of DNA-dependent DNA replication initiation response to estradiol cellular response to insulin stimulus response to drug response to ethanol positive regulation of transcription, DNA-templated response to cadmium ion cell division meiotic cell cycle response to cAMP response to electrical stimulus regulation of cell cycle regulation of gene silencing cellular response to DNA damage stimulus cell cycle phosphorylation G2/M transition of mitotic cell cycle DNA replication DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest centriole replication meiotic nuclear division mitotic G1 DNA damage checkpoint centrosome duplication negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle cellular response to nitric oxide regulation of signal transduction by p53 class mediator JAK-STAT cascade
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