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Osenses
Phospho-CREM (Ser271, Ser274) Polyclonal Antibody
Product Details
OSC00064W-100UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Sheep
/ Ig
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide to phospho S271 & S274 of human CREM (cAMP-responsive element modulator, Inducible cAMP early repressor, ICER) conjugated to an immunogenic carrier protein was used as the antigen
Conjugate
Form
Lyophilized
Concentration
Conc. Not Determined
Storage buffer
whole serum
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
The peptide is homologous in rat, mouse and dog.
Specificity of this antibody: CREM.
Target Information
This gene encodes a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is an important component of cAMP-mediated signal transduction during the spermatogenetic cycle, as well as other complex processes. Alternative promoter and translation initiation site usage allows this gene to exert spatial and temporal specificity to cAMP responsiveness. Multiple alternatively spliced transcript variants encoding several different isoforms have been found for this gene, with some of them functioning as activators and some as repressors of transcription.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: cAMP response element modulator; cAMP responsive element moderator; cAMP-responsive element modulator; CRE modulator; CREM 2alpha-b protein; CREM 2beta-a protein; ICER; Inducible cAMP early repressor; inducible cAMP early repressor ICER; inducible cyclic AMP early repressor; MGC111110; MGC17881; MGC41893; OTTHUMP00000019443
Gene Aliases: CREM; CREM-2; hCREM-2; ICER; ICERI
UniProt ID: (Human) Q03060, (Rat) Q03061, (Mouse) P27699
Entrez Gene ID: (Human) 1390, (Rat) 25620, (Mouse) 12916
glucose metabolic process
transcription, DNA-templated
regulation of transcription, DNA-templated
fatty acid metabolic process
glycosphingolipid metabolic process
spermatogenesis
cAMP-mediated signaling
circadian regulation of gene expression
regulation of circadian rhythm
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
retinoic acid receptor signaling pathway
response to cAMP
rhythmic process
signal transduction
multicellular organism development
cell differentiation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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