Invitrogen

Phospho-CSF1R (Tyr708) Polyclonal Antibody

View all (80) CSF1R (CD115) antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-105137

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human CSF1R(Accession P07333), corresponding to amino acid residues around phosphorylated Tyr708.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

sequential chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2816610

Product Specific Information

Antibody detects endogenous levels of MCSF Receptor only when phosphorylated at Tyr708.

Target Information

CSF1R (FMS) is involved in the production, differentiation, and function of macrophages, and is implicated in promyelocytic leukemias. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. CSF1R is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in the gene encoding CSF1R have been associated with a predisposition to myeloid malignancy.Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines in response to IL34 and CSF1, and plays an important role in innate immunity and in inflammatory processes. The first intron of the CSF1R gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. Mutations in the CSF1R gene have been associated with a predisposition to myeloid malignancy.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: c-fms; CD115; CD115 antigen; CSF-1 receptor; CSF-1-R; CSFIR; EC 2.7.10.1; FMS proto-oncogene; kinase CSFR; macrophage colony stimulating factor I receptor; Macrophage colony-stimulating factor 1 receptor; McDonough feline sarcoma viral (v-fms) oncogene homolog; OTTHUMP00000224093; Proto-oncogene c-Fms; proto-oncogene fms

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Gene Aliases: AI323359; C-FMS; CD115; CSF-1-R; CSF-1R; CSF1R; Csfmr; CSFR; Fim-2; FIM2; FMS; HDLS; M-CSF-R; M-CSFR; mrfms

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UniProt ID: (Human) P07333, (Mouse) P09581

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Entrez Gene ID: (Human) 1436, (Mouse) 12978, (Rat) 307403

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Function(s)
macrophage colony-stimulating factor receptor activity ATP binding protein phosphatase binding cytokine binding protein homodimerization activity nucleotide binding protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity protein binding kinase activity transferase activity transferase activity, transferring phosphorus-containing groups molecular_function
Process(es)
positive regulation of protein phosphorylation immune system process protein phosphorylation inflammatory response transmembrane receptor protein tyrosine kinase signaling pathway cell proliferation positive regulation of cell proliferation regulation of cell shape phosphorylation peptidyl-tyrosine phosphorylation cytokine-mediated signaling pathway hemopoiesis osteoclast differentiation positive regulation of cell migration ruffle organization cellular response to macrophage colony-stimulating factor stimulus macrophage colony-stimulating factor signaling pathway positive regulation of tyrosine phosphorylation of Stat3 protein innate immune response regulation of bone resorption cell-cell junction maintenance positive regulation of osteoclast differentiation phosphatidylinositol metabolic process protein autophosphorylation phosphatidylinositol-mediated signaling positive regulation of protein tyrosine kinase activity positive regulation of ERK1 and ERK2 cascade cellular response to cytokine stimulus positive regulation of protein serine/threonine kinase activity positive regulation of chemokine secretion positive regulation of cell motility regulation of actin cytoskeleton reorganization skeletal muscle tissue development signal transduction multicellular organism development axon guidance negative regulation of cell proliferation olfactory bulb development forebrain neuron differentiation monocyte differentiation macrophage differentiation negative regulation of apoptotic process mammary gland duct morphogenesis
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