AbboMax

Phospho-CamKII (Thr286) Polyclonal Antibody

View all (6) CaMKII alpha/beta/delta antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

600-270

Applications
Tested Dilution
Publications

Western Blot (WB)

0.1-1 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

2-10 µg/mL
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic peptide corresponding to the epitope with a single phosphorylation site Thr 286
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

25mM tris with proprietary stabilizer

Contains

0.01% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

Product Specific Information

Positive control: Human thyroid carcinoma, cardiac and skeletal muscle tissues

Cellular location: Cytoplasm.

Target Information

The Ca2+/calmodulin-dependent protein kinases (CaM kinases) comprise a structurally related subfamily of serine/threonine kinases which include CaMKI, CaMKII and CaMKIV. CaMKII is an ubiquitously expressed serine/threonine protein kinase that is activated by Ca2+ and calmodulin (CaM) and has been implicated in regulation of the cell cycle and transcription. There are four CaMKII isozymes, designated alpha, beta, gamma and delta, which may or may not be co-expressed in the same tissue type. CaMKII alpha is autophosphorylated on Thr 286 upon the binding of the Ca2+/CaM complex to the autoinhibitory domain of CaMKII. This process is called Ca2+/CaM trapping, which is thought to be involved in the synaptic encoding of information.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Calci; calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha; calcium/calmodulin-dependent protein kinase (CaM kinase) II delta; calcium/calmodulin-dependent protein kinase II alpha-B subunit; calcium/calmodulin-dependent protein kinase II beta; calcium/calmodulin-dependent protein kinase II delta; calcium/calmodulin-dependent protein kinase type II alpha chain; calcium/calmodulin-dependent protein kinase type II delta chain; Calcium/calmodulin-dependent protein kinase type II subunit alpha; Calcium/calmodulin-dependent protein kinase type II subunit beta; Calcium/calmodulin-dependent protein kinase type II subunit delta; CaM kinase II alpha subunit; CaM kinase II beta subunit; CaM kinase II delta subunit; CaM kinase II subunit alpha; CaM kinase II subunit beta; CaM kinase II subunit delta; CaM-kinase II alpha chain; CaM-kinase II beta chain; CaM-kinase II delta chain; CAMK; CaMK-2 delta; CaMK-2a; CAMK-II; CaMK-II alpha subunit; CaMK-II delta subunit; caMK-II subunit alpha; caMK-II subunit beta; caMK-II subunit delta; CaMK2 delta; CaMK2- delta; CaMK2-a; CAMK2G; CAMKG; CaMKIINalpha; proline rich calmodulin-dependent protein kinase

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Gene Aliases: CAM2; CAMK2; CAMK2A; CAMK2B; CAMK2D; CAMKA; CAMKB; CAMKD; KIAA0968

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UniProt ID: (Human) Q9UQM7, (Human) Q13554, (Human) Q13557

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Entrez Gene ID: (Human) 815, (Human) 816, (Human) 817

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Function(s)
protein serine/threonine kinase activity calmodulin-dependent protein kinase activity Ras guanyl-nucleotide exchange factor activity protein binding calmodulin binding ATP binding kinase activity glutamate receptor binding protein homodimerization activity actin binding protein kinase binding phospholipase binding sodium channel inhibitor activity titin binding ion channel binding nitric-oxide synthase binding
Process(es)
G1/S transition of mitotic cell cycle MAPK cascade regulation of cell growth response to hypoxia regulation of the force of heart contraction regulation of membrane depolarization regulation of transcription from RNA polymerase II promoter protein phosphorylation calcium ion transport regulation of heart contraction regulation of G2/M transition of mitotic cell cycle positive regulation of cardiac muscle hypertrophy regulation of cell communication by electrical coupling positive regulation of cardiac muscle cell apoptotic process regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion positive regulation of smooth muscle cell migration peptidyl-serine phosphorylation peptidyl-threonine phosphorylation cellular potassium ion homeostasis endoplasmic reticulum calcium ion homeostasis positive regulation of Rac protein signal transduction positive regulation of GTPase activity protein autophosphorylation positive regulation of smooth muscle cell proliferation protein oligomerization relaxation of cardiac muscle regulation of ryanodine-sensitive calcium-release channel activity interferon-gamma-mediated signaling pathway regulation of cellular localization cell growth involved in cardiac muscle cell development positive regulation of ERK1 and ERK2 cascade cellular response to calcium ion cardiac muscle cell contraction regulation of heart rate by cardiac conduction regulation of cardiac muscle cell action potential regulation of cardiac muscle cell action potential involved in regulation of contraction regulation of cellular response to heat regulation of histone deacetylase activity regulation of cell communication by electrical coupling involved in cardiac conduction regulation of relaxation of cardiac muscle negative regulation of sodium ion transmembrane transport regulation of calcium ion transmembrane transport via high voltage-gated calcium channel negative regulation of sodium ion transmembrane transporter activity signal transduction positive regulation of neuron projection development regulation of skeletal muscle adaptation positive regulation of phospholipase A2 activity regulation of long-term neuronal synaptic plasticity cell projection morphogenesis regulation of synapse structural plasticity regulation of calcium ion transport regulation of dendritic spine development positive regulation of dendritic spine morphogenesis positive regulation of synapse maturation response to ischemia Wnt signaling pathway, calcium modulating pathway angiotensin-activated signaling pathway regulation of neurotransmitter secretion regulation of neuronal synaptic plasticity positive regulation of NF-kappaB transcription factor activity positive regulation of calcium ion transport regulation of mitochondrial membrane permeability involved in apoptotic process
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