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Bioss
Phospho-DAG1 (Tyr892) Polyclonal Antibody
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Product Details
BS-4075R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic phosphopeptide derived from human DAG1 around the phosphorylation site of Tyr892.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Dystroglycan is a laminin binding component of the dystrophin-glycoprotein complex which provides a linkage between the subsarcolemmal cytoskeleton and the extracellular matrix. Dystroglycan 1 is a candidate gene for the site of the mutation in autosomal recessive muscular dystrophies. The dramatic reduction of dystroglycan 1 in Duchenne muscular dystrophy leads to a loss of linkage between the sarcolemma and extracellular matrix, rendering muscle fibers more susceptible to necrosis. Dystroglycan also functions as dual receptor for agrin and laminin-2 in the Schwann cell membrane. The muscle and nonmuscle isoforms of dystroglycan differ by carbohydrate moieties but not protein sequence. Alternative splicing results in multiple transcript variants all encoding the same protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: alpha-dystroglycan; beta-dystroglycan; Dystroglycan; Dystroglycan 1; dystroglycan 1 (dystrophin-associated glycoprotein 1); dystrophin associated glycoprotein 1; Dystrophin-associated glycoprotein 1
Gene Aliases: 156DAG; A3a; AGRNR; D9Wsu13e; DAG; DAG1; DG; Dp427; Dp71; MDDGA9; MDDGC7; MDDGC9
UniProt ID: (Human) Q14118, (Mouse) Q62165
Entrez Gene ID: (Human) 1605, (Mouse) 13138, (Rat) 114489
morphogenesis of an epithelial sheet
membrane protein ectodomain proteolysis
NLS-bearing protein import into nucleus
cytoskeletal anchoring at plasma membrane
Schwann cell development
viral process
calcium-dependent cell-matrix adhesion
modulation by virus of host morphology or physiology
nerve maturation
myelination in peripheral nervous system
negative regulation of cell migration
microtubule anchoring
negative regulation of MAPK cascade
negative regulation of protein kinase B signaling
epithelial tube branching involved in lung morphogenesis
branching involved in salivary gland morphogenesis
commissural neuron axon guidance
basement membrane organization
protein O-linked glycosylation
regulation of gastrulation
regulation of epithelial to mesenchymal transition
regulation of embryonic cell shape
extracellular matrix organization
response to peptide hormone
viral entry into host cell
positive regulation of basement membrane assembly involved in embryonic body morphogenesis
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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