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Invitrogen
Phospho-DNM1L (Ser637) Polyclonal Antibody
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Product Details
PA5-117217
Product Specifications
Species Reactivity
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic phosphorylated peptide around S637 of human DRP1 (NP_0361922)
Conjugate
Form
Liquid
Concentration
0.82 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2901847
Product Specific Information
Positive Samples: PC-12
Immunogen sequence: KLSARE
Target Information
A human dynamin-related protein, DRP1 contributes to mitochondrial division in mammalian cells. It plays this important role in mitochondrial fission at steady state and during apoptosis. DRP1 is required for proper cellular distribution of mitochondria, and in mutant neurons, mitochondria are largely absent from synapses, thus providing a genetic tool to assess the role of mitochondria at synapses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: C-terminal region; Dynamin-1-like protein; Dynamin-like protein; dynamin-like protein 1; dynamin-related protein 1; DYNIV 11; DYNIV-11; EC 3.6.5.5; FLJ41912; N-terminal region; VPS1
Gene Aliases: DLP1; Dnm1l; Dnml1; Drp1
UniProt ID: (Rat) O35303
Entrez Gene ID: (Rat) 114114
mitochondrial fission
release of cytochrome c from mitochondria
dynamin polymerization involved in mitochondrial fission
endocytosis
metabolic process
regulation of mitochondrion organization
peroxisome fission
regulation of protein oligomerization
positive regulation of apoptotic process
mitochondrial fragmentation involved in apoptotic process
positive regulation of protein secretion
protein homotetramerization
membrane fusion
necroptotic process
mitochondrion morphogenesis
protein localization to mitochondrion
positive regulation of mitochondrial fission
mitochondrial membrane fission
positive regulation of release of cytochrome c from mitochondria
regulation of peroxisome organization
regulation of mitophagy
positive regulation of intrinsic apoptotic signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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