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Product Details
BS-11548R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic phosphopeptide derived from human Dab1 around the phosphorylation site of Tyr198 [V (p-Y)QY].
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper layer. This gene is similar to disabled-1, and the protein encoded by this gene is thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Dab reelin signal transducer 1; Dab, reelin signal transducer, homolog 1; Disabled homolog 1; mDab1; RP23-356E21.1; yotari
Gene Aliases: AI956902; C630028C02Rik; DAB1; scm; scr; scrambler; yot
UniProt ID: (Human) O75553, (Rat) Q8CJH2, (Mouse) P97318
Entrez Gene ID: (Human) 1600, (Rat) 266729, (Mouse) 13131
neuron migration
negative regulation of cell adhesion
small GTPase mediated signal transduction
brain development
midgut development
adult walking behavior
dendrite development
ventral spinal cord development
cerebellum structural organization
cerebral cortex cell migration
cerebral cortex radially oriented cell migration
cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration
radial glia guided migration of Purkinje cell
cerebral cortex development
response to drug
positive regulation of neuron differentiation
positive regulation of protein kinase activity
negative regulation of JAK-STAT cascade
negative regulation of astrocyte differentiation
negative regulation of axonogenesis
Golgi localization
lateral motor column neuron migration
multicellular organism development
nervous system development
central nervous system development
cell differentiation
intracellular signal transduction
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