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Invitrogen
Phospho-Dematin (Ser403) Polyclonal Antibody
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Product Details
PA5-99470
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human DMTN(Accession Q08495), corresponding to amino acid residues around phosphorylated Ser403.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
sequential chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2818403
Product Specific Information
Antibody detects endogenous levels of Dematin only when phosphorylated at Ser403.
Target Information
The protein encoded by this gene is an actin binding and bundling protein that plays a structural role in erythrocytes, by stabilizing and attaching the spectrin/actin cytoskeleton to the erythrocyte membrane in a phosphorylation-dependent manner. This protein contains a core domain in the N-terminus, and a headpiece domain in the C-terminus that binds F-actin. When purified from erythrocytes, this protein exists as a trimer composed of two 48 kDa polypeptides and a 52 kDa polypeptide. The different subunits arise from alternative splicing in the 3' coding region, where the headpiece domain is located. Disruption of this gene has been correlated with the autosomal dominant Marie Unna hereditary hypotrichosis disease, while loss of heterozygosity of this gene is thought to play a role in prostate cancer progression. Alternative splicing results in multiple transcript variants encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Dematin; Dematin actin-binding protein; Erythrocyte membrane protein band 4.9; erythrocyte membrane protein band 4.9 (dematin); erythrocyte protein band 4.9
Gene Aliases: AI325486; dematin; DMT; DMTN; Epb4.9; EPB49
UniProt ID: (Human) Q08495, (Mouse) Q9WV69
Entrez Gene ID: (Human) 2039, (Mouse) 13829
protein complex assembly
cytoskeleton organization
regulation of cell shape
regulation of lamellipodium assembly
positive regulation of fibroblast migration
negative regulation of peptidyl-threonine phosphorylation
negative regulation of cell-substrate adhesion
actin cytoskeleton organization
positive regulation of blood coagulation
regulation of actin cytoskeleton organization
negative regulation of peptidyl-serine phosphorylation
calcium-mediated signaling using intracellular calcium source
calcium-mediated signaling using extracellular calcium source
erythrocyte development
negative regulation of peptidyl-tyrosine phosphorylation
actin filament bundle assembly
regulation of filopodium assembly
actin filament capping
negative regulation of focal adhesion assembly
transmembrane transport
protein secretion by platelet
cellular response to calcium ion
cellular response to cAMP
positive regulation of wound healing
negative regulation of protein targeting to membrane
actin filament reorganization
negative regulation of substrate adhesion-dependent cell spreading
positive regulation of substrate adhesion-dependent cell spreading
positive regulation of platelet aggregation
positive regulation of integrin-mediated signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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