Product References
Induction of proteasomal activity in mammalian cells by lifespan-extending tRNA synthetase inhibitors.
GeroScience
Mariner BL,Rodriguez AS,Heath OC,McCormick MA
44-728G was used in Western Blot to show that multiple tRNA synthetase inhibitors can greatly upregulate activity of the ubiquitin proteasome system (UPS) in cells in an ATF4-dependent manner.
Mon Apr 01 00:00:00 UTC 2024
TRNT-1 Deficiency Is Associated with Loss of tRNA Integrity and Imbalance of Distinct Proteins.
Genes
Fatica T,Naas T,Liwak U,Slaa H,Souaid M,Frangione B,Kattini R,Gaudreau-Lapierre A,Trinkle-Mulcahy L,Chakraborty P,Holcik M
44-728G was used in Western Blotting to suggest that the observed variable SIFD phenotypes are likely due to dysregulation of tRNA maturation and abundance, which in turn negatively affects the translation of distinct proteins.
Fri May 05 00:00:00 UTC 2023
The transcription factor Xrp1 orchestrates both reduced translation and cell competition upon defective ribosome assembly or function.
eLife
Kiparaki M,Khan C,Folgado-Marco V,Chuen J,Moulos P,Baker NE
44-728G was used in Immunohistochemistry to show that transcription factor Xrp1is the master regulator that triggers multiple consequences of ribosomal stresses and is the key instigator of cell competition.
Fri Feb 18 00:00:00 UTC 2022
Triangulating variation in the population to define mechanisms for precision management of genetic disease.
Structure (London, England : 1993)
Wang C,Anglès F,Balch WE
44-728G was used in Western Blot to define the molecular mechanisms of clinically approved CF chemical modulators.
Thu Aug 04 00:00:00 UTC 2022
Inhibiting IRE-1 RNase signaling decreases HIV-1 Tat-induced inflammatory M1 state in microglial cells.
Biochimica et biophysica acta. General subjects
Roberto Pinto A,Américo MF,Terenzi H,Silveira DB
44-728G was used in Western Blotting to show that blocking IRE1/XBP-1 signaling using 4µ8C diminishes such inflammatory response.
Tue Nov 01 00:00:00 UTC 2022
The hepatic integrated stress response suppresses the somatotroph axis to control liver damage in nonalcoholic fatty liver disease.
Cell reports
Ohkubo R,Mu WC,Wang CL,Song Z,Barthez M,Wang Y,Mitchener N,Abdullayev R,Lee YR,Ma Y,Curtin M,Srinivasan S,Zhang X,Yang F,Sudmant PH,Pisco AO,Neff N,Haynes CM,Chen D
44-728G was used in Western Blotting to establish that the hepatic ISR suppresses the somatotroph axis to control cell fate decisions and liver damage in NAFLD.
Tue Dec 13 00:00:00 UTC 2022
Dexmedetomidine Preconditioning Reduces Myocardial Ischemia-Reperfusion Injury in Rats by Inhibiting the PERK Pathway.
Arquivos brasileiros de cardiologia
Chen Y,Cao S,Chen H,Yin C,Xu X,Yang Z
44-728G was used in Western Blotting to evaluate if dexmedetomidine (DEX) has a protective effect in myocardiual ischemia-reperfusion and explore the possible mechanism behind it.
Wed Dec 01 00:00:00 UTC 2021
Bio-nanoparticle based therapeutic vaccine induces immunogenic response against triple negative breast cancer.
American journal of cancer research
Bai X,Zhou Y,Lin Q,Huang CK,Zhang S,Carlson RI,Ghanbari H,Sun B,Wands JR,Dong X
44-728G was used in Immunocytochemistry, Western Blot to conclude that λ phage vaccine targeting a TAA (ASPH) combined with DOX successfully induces ICD and initiates CD8+ T cell-mediated antitumor immunity in breast tumors.
Tue May 07 00:00:00 UTC 2024
ERAD components Derlin-1 and Derlin-2 are essential for postnatal brain development and motor function.
iScience
Sugiyama T,Murao N,Kadowaki H,Takao K,Miyakawa T,Matsushita Y,Katagiri T,Futatsugi A,Shinmyo Y,Kawasaki H,Sakai J,Shiomi K,Nakazato M,Takeda K,Mikoshiba K,Ploegh HL,Ichijo H,Nishitoh H
44-728G was used in Western Blot to demonstrate that Derlins sustain brain cholesterol biosynthesis, which is essential for appropriate postnatal brain development and function.
Fri Jul 23 00:00:00 UTC 2021
Exercise training mitigates ER stress and UCP2 deficiency-associated coronary vascular dysfunction in atherosclerosis.
Scientific reports
Hong J,Park E,Lee J,Lee Y,Rooney BV,Park Y
44-728G was used in Western Blot to unravel the mechanisms behind exercise-induced reduction of endoplasmic reticulum stress, uncoupling protein-2 activation and the enhancement of endothelial function.
Thu Jul 29 00:00:00 UTC 2021
Proteostasis in dendritic cells is controlled by the PERK signaling axis independently of ATF4.
Life science alliance
Mendes A,Gigan JP,Rodriguez Rodrigues C,Choteau SA,Sanseau D,Barros D,Almeida C,Camosseto V,Chasson L,Paton AW,Paton JC,Argüello RJ,Lennon-Duménil AM,Gatti E,Pierre P
44-728G was used in Immunohistochemistry to show that DCs are characterized by high eIF2α phosphorylation, mostly caused by the activation of the ER kinase PERK (EIF2AK3). Despite high p-eIF2α levels, DCs display active protein synthesis and no signs of a chronic integrated stress response.
Mon Feb 01 00:00:00 UTC 2021
Magnesium depletion extends fission yeast lifespan via general amino acid control activation.
MicrobiologyOpen
Ohtsuka H,Kobayashi M,Shimasaki T,Sato T,Akanuma G,Kitaura Y,Otsubo Y,Yamashita A,Aiba H
44-728G was used in Western Blot to investigate effects of magnesium on Schizosaccharomyces pombe lifespan.
Mon Mar 01 00:00:00 UTC 2021
Mitochondrial stress is relayed to the cytosol by an OMA1-DELE1-HRI pathway.
Nature
Guo X,Aviles G,Liu Y,Tian R,Unger BA,Lin YT,Wiita AP,Xu K,Correia MA,Kampmann M
44-728G was used in Western Blotting to identify the molecular players that signal mitochondrial stress to the cytosol.
Sun Mar 01 00:00:00 UTC 2020
RNA-Induced Conformational Switching and Clustering of G3BP Drive Stress Granule Assembly by Condensation.
Cell
Guillén-Boixet J,Kopach A,Holehouse AS,Wittmann S,Jahnel M,Schlüßler R,Kim K,Trussina IREA,Wang J,Mateju D,Poser I,Maharana S,Ruer-Gruß M,Richter D,Zhang X,Chang YT,Guck J,Honigmann A,Mahamid J,Hyman AA,Pappu RV,Alberti S,Franzmann TM
44-728G was used in Western Blotting to propose that condensation coupled to conformational rearrangements and heterotypic multivalent interactions may be a general principle underlying RNP granule assembly.
Thu Apr 16 00:00:00 UTC 2020
Exercise training ameliorates cerebrovascular dysfunction in a murine model of Alzheimer's disease: role of the P2Y2 receptor and endoplasmic reticulum stress.
American journal of physiology. Heart and circulatory physiology
Hong J,Hong SG,Lee J,Park JY,Eriksen JL,Rooney BV,Park Y
44-728G was used in Western Blot to study the effects of exercise training on purinergic P2Y2 receptor and endoplasmic reticulum stress associated with cerebrovascular dysfunction in Alzheimer's disease pathogenesis.
Mon Jun 01 00:00:00 UTC 2020
The switch-like expression of heme-regulated kinase 1 mediates neuronal proteostasis following proteasome inhibition.
eLife
Alvarez-Castelao B,Tom Dieck S,Fusco CM,Donlin-Asp P,Perez JD,Schuman EM
44-728G was used in Western Blotting to demonstrate a novel role for neuronal HRI that senses and responds to compromised function of the proteasome to restore proteostasis.
Fri Apr 24 00:00:00 UTC 2020
eIF2B as a Target for Viral Evasion of PKR-Mediated Translation Inhibition.
mBio
Wuerth JD,Habjan M,Kainulainen M,Berisha B,Bertheloot D,Superti-Furga G,Pichlmair A,Weber F
44-728G was used in Western Blotting to report a different PKR escape strategy executed by sandfly fever Sicilian virus (SFSV), a member of the increasingly important group of phleboviruses.
Tue Jul 14 00:00:00 UTC 2020
Protein Stability Buffers the Cost of Translation Attenuation following eIF2α Phosphorylation.
Cell reports
Schneider K,Nelson GM,Watson JL,Morf J,Dalglish M,Luh LM,Weber A,Bertolotti A
44-728G was used in Western Blotting to determine that after phosphorylation of the translation initiation factor eIF2α, protein stability buffers the cost of translational attenuation.
Tue Sep 15 00:00:00 UTC 2020
Hypomodified tRNA in evolutionarily distant yeasts can trigger rapid tRNA decay to activate the general amino acid control response, but with different consequences.
PLoS genetics
De Zoysa T,Phizicky EM
44-728G was used in Western Blotting to show that S. pombe trm8Δ mutants are temperature sensitive primarily due to decay of tRNATyr(GUA) and that spontaneous mutations in the RAT1 ortholog dhp1+ restored temperature resistance and prevented tRNA decay, demonstrating conservation of the RTD pathway.
Sat Aug 01 00:00:00 UTC 2020
Proteome dynamics during homeostatic scaling in cultured neurons.
eLife
Dörrbaum AR,Alvarez-Castelao B,Nassim-Assir B,Langer JD,Schuman EM
44-728G was used in Western Blot to demonstrate that a large fraction of the neuronal proteome shows changes in protein synthesis and/or degradation during homeostatic up- and down-scaling.
Thu Apr 02 00:00:00 UTC 2020
Domain II of the translation elongation factor eEF1A is required for Gcn2 kinase inhibition.
FEBS letters
Ramesh R,Sattlegger E
44-728G was used in Western Blotting to show that domain II of eEF1A plays an essential role in Gcn2 inhibition, while absence of domain III affects Gcn2 response pathways to impair eIF2α phosphorylation.
Wed Jul 01 00:00:00 UTC 2020
TEX264 Is an Endoplasmic Reticulum-Resident ATG8-Interacting Protein Critical for ER Remodeling during Nutrient Stress.
Molecular cell
An H,Ordureau A,Paulo JA,Shoemaker CJ,Denic V,Harper JW
44-728G was used in Western Blotting to demonstrate single-pass transmembrane ER protein, TEX264, is an ER-phagy receptor and remodels the ER during nutrient stress.
Thu Jun 06 00:00:00 UTC 2019
HDAC inhibitors rescue multiple disease-causing CFTR variants.
Human molecular genetics
Anglès F,Hutt DM,Balch WE
44-728G was used in Western Blotting to indicate that the HDACimediated correction of the F508del variant can be extended to other ER-restricted Class II and III variants.
Sat Jun 15 00:00:00 UTC 2019
Evaluation of the Antiviral Activity of Sephin1 Treatment and Its Consequences on eIF2α Phosphorylation in Response to Viral Infections.
Frontiers in immunology
Fusade-Boyer M,Dupré G,Bessière P,Khiar S,Quentin-Froignant C,Beck C,Lecollinet S,Rameix-Welti MA,Eléouët JF,Tangy F,Lajoie B,Bertagnoli S,Vidalain PO,Gallardo F,Volmer R
44-728G was used in Western Blotting to demonstrate that Sephin1 downregulates replication of human respiratory syncytial virus, measles virus, human adenovirus 5 virus, human enterovirus D68, human cytomegalovirus, and rabbit myxoma virus.
Mon Jan 06 00:00:00 UTC 2020
Mitochondrial oxidative stress-induced transcript variants of ATF3 mediate lipotoxic brain microvascular injury.
Free radical biology & medicine
Nyunt T,Britton M,Wanichthanarak K,Budamagunta M,Voss JC,Wilson DW,Rutledge JC,Aung HH
44-728G was used in Western Blot to indicate that ATF3-T4 predominantly regulates the TL-induced brain microvascular inflammation and TNF signaling.
Fri Nov 01 00:00:00 UTC 2019
Translation of upstream open reading frames in a model of neuronal differentiation.
BMC genomics
Rodriguez CM,Chun SY,Mills RE,Todd PK
44-728G was used in Western Blotting to identify 4954 consistently translated uORFs across 31% of all neuroblastoma transcripts, via a spectral coherence algorithm (SPECtre).
Mon May 20 00:00:00 UTC 2019
Oxidative stress promotes SIRT1 recruitment to the GADD34/PP1α complex to activate its deacetylase function.
Cell death and differentiation
Lee IC,Ho XY,George SE,Goh CW,Sundaram JR,Pang KKL,Luo W,Yusoff P,Sze NSK,Shenolikar S
44-728G was used in Western Blotting to study the role of the GADD34/PP1α complex in coordinating cellular processes to determine cell fate following oxidative stress.
Thu Feb 01 00:00:00 UTC 2018
HRI-mediated translational repression reduces proteotoxicity and sensitivity to bortezomib in human pancreatic cancer cells.
Oncogene
White MC,Schroeder RD,Zhu K,Xiong K,McConkey DJ
44-728G was used in Western Blotting to implicate inducible HRI-mediated phosphorylation of eIF2α as a central cytoprotective mechanism following exposure to bortezomib and provide proof-of-concept for the development of HRI inhibitors to overcome proteasome inhibitor resistance.
Wed Aug 01 00:00:00 UTC 2018
Exacerbated Apoptosis of Cells Infected with Infectious Bursal Disease Virus upon Exposure to Interferon Alpha.
Journal of virology
Cubas-Gaona LL,Diaz-Beneitez E,Ciscar M,Rodríguez JF,Rodríguez D
44-728G was used in Western Blotting to study how exposure to type I interferon leads to apoptotic death of infectious bursal disease virus infected cells.
Fri Jun 01 00:00:00 UTC 2018
PKR modulates abnormal brain signaling in experimental obesity.
PloS one
Taga M,Mouton-Liger F,Sadoune M,Gourmaud S,Norman J,Tible M,Thomasseau S,Paquet C,Nicoll JAR,Boche D,Hugon J
44-728G was used in Western Blotting to study brain metabolic inflammasome ("metaflammasome") proteins in response to a high fat diet, and investigate the role of PKR in abnormal brain signaling.
Mon Aug 06 00:00:00 UTC 2018
Integrated Stress Response Activity Marks Stem Cells in Normal Hematopoiesis and Leukemia.
Cell reports
van Galen P,Mbong N,Kreso A,Schoof EM,Wagenblast E,Ng SWK,Krivdova G,Jin L,Nakauchi H,Dick JE
44-728G was used in Flow Cytometry to identify a link between the ISR and stem cell survival in the normal and leukemic contexts.
Tue Oct 30 00:00:00 UTC 2018
Single amino acid substitution in LC-CDR1 induces Russell body phenotype that attenuates cellular protein synthesis through eIF2α phosphorylation and thereby downregulates IgG secretion despite operational secretory pathway traffic.
mAbs
Hasegawa H,Hsu A,Tinberg CE,Siegler KE,Nazarian AA,Tsai MM
44-728G was used in Immunocytochemistry-immunoflourescence to illustrate that the underlining process of poor Ig secretion in RB-positive cells was due to downregulation of Ig synthesis instead of a disruption or blockade of secretory pathway trafficking.
Sat Jul 01 00:00:00 UTC 2017
General Control Nonderepressible 2 (GCN2) Kinase Inhibits Target of Rapamycin Complex 1 in Response to Amino Acid Starvation in Saccharomyces cerevisiae.
The Journal of biological chemistry
Yuan W,Guo S,Gao J,Zhong M,Yan G,Wu W,Chao Y,Jiang Y
44-728G was used in Western Blot to demonstrate that TORC1 is an effector of Gcn2 in amino acid signaling.
Fri Feb 17 00:00:00 UTC 2017
mTORC1 inhibition in cancer cells protects from glutaminolysis-mediated apoptosis during nutrient limitation.
Nature communications
Villar VH,Nguyen TL,Delcroix V,Terés S,Bouchecareilh M,Salin B,Bodineau C,Vacher P,Priault M,Soubeyran P,Durán RV
44728G was used in western blot to elucidate that mTORC1 presents tumor suppressor features in conditions of nutrient restrictions
Mon Jan 23 00:00:00 UTC 2017
Ebola Virus Does Not Induce Stress Granule Formation during Infection and Sequesters Stress Granule Proteins within Viral Inclusions.
Journal of virology
Nelson EV,Schmidt KM,Deflubé LR,Doğanay S,Banadyga L,Olejnik J,Hume AJ,Ryabchikova E,Ebihara H,Kedersha N,Ha T,Mühlberger E
44-728G was used in western blot to study the sequesteration of stress granule proteins with viral inclusions and lack of stress granule formation during infection by Ebola virus
Mon Aug 15 00:00:00 UTC 2016
NSs Virulence Factor of Rift Valley Fever Virus Engages the F-Box Proteins FBXW11 and β-TRCP1 To Degrade the Antiviral Protein Kinase PKR.
Journal of virology
Kainulainen M,Lau S,Samuel CE,Hornung V,Weber F
44728G was used in western blot to identify components of the modular SCF-type E3 ubiquitin ligases as mediators of PKR destruction by Rift Valley fever virus non-structural proteins
Fri Jul 01 00:00:00 UTC 2016
Infantile Cirrhosis, Growth Impairment, and Neurodevelopmental Anomalies Associated with Deficiency of PPP1R15B.
The Journal of pediatrics
Mohammad S,Wolfe LA,Stöbe P,Biskup S,Wainwright MS,Melin-Aldana H,Malladi P,Muenke M,Gahl WA,Whitington PF
44728G was used in western blot to use whole-exome sequencing in a sibling pair with undetermined liver disease to identify mutations
Thu Dec 01 00:00:00 UTC 2016
Chronology of UPR activation in skeletal muscle adaptations to chronic contractile activity.
American journal of physiology. Cell physiology
Memme JM,Oliveira AN,Hood DA
44-728G was used in Western Blot to investigate the role of the UPR in exercise-induced adaptations.
Wed Jun 01 00:00:00 UTC 2016
Perturbations in actin dynamics reconfigure protein complexes that modulate GCN2 activity and promote an eIF2 response.
Journal of cell science
Silva RC,Sattlegger E,Castilho BA
44728G was used in western blot to propose that GCN2 is an important sensor of the state of the actin cytoskeleton
Thu Dec 15 00:00:00 UTC 2016
Stress Granule Induction after Brain Ischemia Is Independent of Eukaryotic Translation Initiation Factor (eIF) 2α Phosphorylation and Is Correlated with a Decrease in eIF4B and eIF4E Proteins.
The Journal of biological chemistry
Ayuso MI,Martínez-Alonso E,Regidor I,Alcázar A
44728G was used in western blot to link eIF4B and eIF4E alterations to the induction of stress granules in regions of the brain vulnerable to death after ischemia-reperfusion injury
Fri Dec 30 00:00:00 UTC 2016
PERK Regulates Working Memory and Protein Synthesis-Dependent Memory Flexibility.
PloS one
Zhu S,Henninger K,McGrath BC,Cavener DR
44-728G was used in western blot assess the role of PERK to working memory
Fri Aug 11 00:00:00 UTC 2017
Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunit.
Science (New York, N.Y.)
Das I,Krzyzosiak A,Schneider K,Wrabetz L,D'Antonio M,Barry N,Sigurdardottir A,Bertolotti A
44-728G was used in western blot to show that Sephin1, a selective inhibitor of protein phosphatase 1, protects mice from protein-misfolding disease.
Fri Apr 10 00:00:00 UTC 2015
Hepatocyte Nicotinamide Adenine Dinucleotide Phosphate Reduced Oxidase 4 Regulates Stress Signaling, Fibrosis, and Insulin Sensitivity During Development of Steatohepatitis in Mice.
Gastroenterology
Bettaieb A,Jiang JX,Sasaki Y,Chao TI,Kiss Z,Chen X,Tian J,Katsuyama M,Yabe-Nishimura C,Xi Y,Szyndralewiez C,Schröder K,Shah A,Brandes RP,Haj FG,Török NJ
44-728G was used in western blot to investigate the effects of nicotinamide adenine dinucleotide phosphate reduced oxidase 4 in liver tissues from patients with NASH and mice with steatohepatitis.
Sat Aug 01 00:00:00 UTC 2015
The impact of the phosphomimetic eIF2αS/D on global translation, reinitiation and the integrated stress response is attenuated in N2a cells.
Nucleic acids research
Legrand N,Jaquier-Gubler P,Curran J
44-728G was used in western blot to show that the inhibitory and reinitiation functions of eIF2αS/D are separate.
Wed Sep 30 00:00:00 UTC 2015
The role of NOS-mediated ROS accumulation in an early phase Cu-induced acute cytotoxicity in MCF-7 cells.
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine
Zhong L,Wang L,Xu L,Liu Q,Jiang L,Zhi Y,Lu W,Zhou P
44-728G was used in western blot to test if the nitric oxide synthase signaling pathway contributes to Cu-induced acute cytotoxicity
Sun Feb 01 00:00:00 UTC 2015
Impaired protein translation in Drosophila models for Charcot-Marie-Tooth neuropathy caused by mutant tRNA synthetases.
Nature communications
Niehues S,Bussmann J,Steffes G,Erdmann I,Köhrer C,Sun L,Wagner M,Schäfer K,Wang G,Koerdt SN,Stum M,Jaiswal S,RajBhandary UL,Thomas U,Aberle H,Burgess RW,Yang XL,Dieterich D,Storkebaum E
44-728G was used in western blot to develop a Drosophila model for Charcot-Marie-Tooth by mutating glycyl-tRNA synthetase
Fri Jul 03 00:00:00 UTC 2015
The Gcn2 Regulator Yih1 Interacts with the Cyclin Dependent Kinase Cdc28 and Promotes Cell Cycle Progression through G2/M in Budding Yeast.
PloS one
Silva RC,Dautel M,Di Genova BM,Amberg DC,Castilho BA,Sattlegger E
44-728G was used in western blot to demonstrate that Yih1/IMPACT are involved in the cell cycle regulation.
Thu Apr 21 00:00:00 UTC 2016
The role of nitric oxide synthase signaling pathway in the Zn-induced cellular responses in MCF-7 cells.
Environmental toxicology and pharmacology
Zhong L,Wang L,Xu L,Liu Q,Jiang L,Zhi Y,Lu W,Zhou P
44-728G was used in western blot to test if zinc regulates NOS signaling
Sat Nov 01 00:00:00 UTC 2014
Crosstalk between the Tor and Gcn2 pathways in response to different stresses.
Cell cycle (Georgetown, Tex.)
Rødland GE,Tvegård T,Boye E,Grallert B
44-728G was used in western blot to use the model organism Schizosaccharomyces pombe to investigate TORC1 and Gcn2 crosstalk.
Wed Jan 14 00:00:00 UTC 2015
The unfolded protein response and the phosphorylations of activating transcription factor 2 in the trans-activation of il23a promoter produced by β-glucans.
The Journal of biological chemistry
Rodríguez M,Domingo E,Alonso S,Frade JG,Eiros J,Crespo MS,Fernández N
44-728G was used in western blot to study the effect of zymosan treatment on IL-23 production
Fri Aug 15 00:00:00 UTC 2014
Suppression of eIF2α kinases alleviates Alzheimer's disease-related plasticity and memory deficits.
Nature neuroscience
Ma T,Trinh MA,Wexler AJ,Bourbon C,Gatti E,Pierre P,Cavener DR,Klann E
44-728G was used in immunohistochemistry - free floating and western blot to test if suppressing eIF2alpha kinases alleviates synaptic plasticity and memory deficits in a mouse model of Alzheimer's disease
Sun Sep 01 00:00:00 UTC 2013
C/EBP homologous protein (CHOP) contributes to suppression of metabolic genes during endoplasmic reticulum stress in the liver.
The Journal of biological chemistry
Chikka MR,McCabe DD,Tyra HM,Rutkowski DT
44-728G was used in western blot to test if the unfolded protein response-regulated CCAAT/enhancer-binding protein homologous protein participates in the transcriptional regulation of metabolism during hepatic ER stress.
Fri Feb 08 00:00:00 UTC 2013
Induction of a G1-S checkpoint in fission yeast.
Proceedings of the National Academy of Sciences of the United States of America
Bøe CA,Krohn M,Rødland GE,Capiaghi C,Maillard O,Thoma F,Boye E,Grallert B
Tue Jun 19 00:00:00 UTC 2012
Murine cytomegalovirus targets transcription factor ATF4 to exploit the unfolded-protein response.
Journal of virology
Qian Z,Xuan B,Chapa TJ,Gualberto N,Yu D
Fri Jun 01 00:00:00 UTC 2012
Accumulation of autophagosomes in Semliki Forest virus-infected cells is dependent on expression of the viral glycoproteins.
Journal of virology
Eng KE,Panas MD,Murphy D,Karlsson Hedestam GB,McInerney GM
Tue May 01 00:00:00 UTC 2012
The infectious bursal disease virus RNA-binding VP3 polypeptide inhibits PKR-mediated apoptosis.
PloS one
Busnadiego I,Maestre AM,Rodríguez D,Rodríguez JF
Fri May 03 00:00:00 UTC 2013
The infectious bursal disease virus RNA-binding VP3 polypeptide inhibits PKR-mediated apoptosis.
PloS one
Busnadiego I,Maestre AM,Rodríguez D,Rodríguez JF
Fri May 03 00:00:00 UTC 2013
The infectious bursal disease virus RNA-binding VP3 polypeptide inhibits PKR-mediated apoptosis.
PloS one
Busnadiego I,Maestre AM,Rodríguez D,Rodríguez JF
Fri May 03 00:00:00 UTC 2013
The chemotherapeutic drug 5-fluorouracil promotes PKR-mediated apoptosis in a p53-independent manner in colon and breast cancer cells.
PloS one
García MA,Carrasco E,Aguilera M,Alvarez P,Rivas C,Campos JM,Prados JC,Calleja MA,Esteban M,Marchal JA,Aránega A
44-728G was used in western blot to identify factors that regulate in 5-FU-induced apoptosis
Fri Feb 24 00:00:00 UTC 2012
Phosphorylation of eIF2 facilitates ribosomal bypass of an inhibitory upstream ORF to enhance CHOP translation.
The Journal of biological chemistry
Palam LR,Baird TD,Wek RC
44-728G was used in immunocytochemistry to investigate the relationship between eIF2 phosphorylation and CHOP during the stress response.
Fri Apr 01 00:00:00 UTC 2011
A crucial role for RACK1 in the regulation of glucose-stimulated IRE1alpha activation in pancreatic beta cells.
Science signaling
Qiu Y,Mao T,Zhang Y,Shao M,You J,Ding Q,Chen Y,Wu D,Xie D,Lin X,Gao X,Kaufman RJ,Li W,Liu Y
Tue Jan 26 00:00:00 UTC 2010
Translation control by protein kinase R restricts minute virus of mice infection: role in parvovirus oncolysis.
Journal of virology
Ventoso I,Berlanga JJ,Almendral JM
44-728G was used in western blot to investigate the translational control and oncotropism of the MVMp virus
Sat May 01 00:00:00 UTC 2010
Ectopic expression of eIF2Bepsilon in rat skeletal muscle rescues the sepsis-induced reduction in guanine nucleotide exchange activity and protein synthesis.
American journal of physiology. Endocrinology and metabolism
Tuckow AP,Vary TC,Kimball SR,Jefferson LS
Sun Aug 01 00:00:00 UTC 2010
Methylation of ribosomal protein L42 regulates ribosomal function and stress-adapted cell growth.
The Journal of biological chemistry
Shirai A,Sadaie M,Shinmyozu K,Nakayama J
44-728G was used in western blot to report a novel regulatory role of ribosomal protein methylation
Fri Jul 16 00:00:00 UTC 2010
Endoplasmic reticulum stress induced by aqueous extracts of cigarette smoke in 3T3 cells activates the unfolded-protein-response-dependent PERK pathway of cell survival.
Free radical biology & medicine
Hengstermann A,Müller T
44-728G was used in western blot to investigate how cigarette smoke induces endoplasmic reticulum stress
Sat Mar 15 00:00:00 UTC 2008
Preserved protein synthesis in the heart in response to acute fasting and chronic food restriction despite reductions in liver and skeletal muscle.
American journal of physiology. Endocrinology and metabolism
Yuan CL,Sharma N,Gilge DA,Stanley WC,Li Y,Hatzoglou M,Previs SF
44-728G was used in western blot to examine cardiac and liver protein synthesis after nutritional perturbations
Tue Jul 01 00:00:00 UTC 2008
Phosphorylation of eIF2 directs ATF5 translational control in response to diverse stress conditions.
The Journal of biological chemistry
Zhou D,Palam LR,Jiang L,Narasimhan J,Staschke KA,Wek RC
44-728G was used in western blot to identify transcription factors translationally regulated by eIF2 kinases
Fri Mar 14 00:00:00 UTC 2008
Differential control of the CCAAT/enhancer-binding protein beta (C/EBPbeta) products liver-enriched transcriptional activating protein (LAP) and liver-enriched transcriptional inhibitory protein (LIP) and the regulation of gene expression during the response to endoplasmic reticulum stress.
The Journal of biological chemistry
Li Y,Bevilacqua E,Chiribau CB,Majumder M,Wang C,Croniger CM,Snider MD,Johnson PF,Hatzoglou M
44-728G was used in western blot to examine the effect of altering the LIP/LAP ratio on endoplasmic reticulum stress
Fri Aug 15 00:00:00 UTC 2008
The double-stranded RNA-activated protein kinase mediates radiation resistance in mouse embryo fibroblasts through nuclear factor kappaB and Akt activation.
Clinical cancer research : an official journal of the American Association for Cancer Research
von Holzen U,Pataer A,Raju U,Bocangel D,Vorburger SA,Liu Y,Lu X,Roth JA,Aggarwal BB,Barber GN,Keyomarsi K,Hunt KK,Swisher SG
Mon Oct 15 00:00:00 UTC 2007
Hippocampal cellular stress responses after global brain ischemia and reperfusion.
Antioxidants & redox signaling
Roberts GG,Di Loreto MJ,Marshall M,Wang J,DeGracia DJ
44-728G was used in western blot to examine relative expressions of unfolded protein response-related (ATF4, CHOP, GRP78, XBP-1) and heat shock response-related (HSP70 and HSC70) mRNA transcripts and proteins after brain ischemia and reperfusion
Sat Dec 01 00:00:00 UTC 2007
Impaired dexamethasone-mediated induction of tryptophan 2,3-dioxygenase in heme-deficient rat hepatocytes: translational control by a hepatic eIF2alpha kinase, the heme-regulated inhibitor.
The Journal of pharmacology and experimental therapeutics
Liao M,Pabarcus MK,Wang Y,Hefner C,Maltby DA,Medzihradszky KF,Salas-Castillo SP,Yan J,Maher JJ,Correia MA
Sat Dec 01 00:00:00 UTC 2007
Enhanced antiglioma activity of chimeric HCMV/HSV-1 oncolytic viruses.
Gene therapy
Shah AC,Parker JN,Gillespie GY,Lakeman FD,Meleth S,Markert JM,Cassady KA
44-728G was used in western blot to characterize herpes simplex virus-1 gamma(1)34.5 mutants
Sun Jul 01 00:00:00 UTC 2007
The eukaryotic initiation factor-2 kinase pathway facilitates differential GADD45a expression in response to environmental stress.
The Journal of biological chemistry
Jiang HY,Jiang L,Wek RC
44-728G was used in western blot to investigate the differential expression of GADD45a
Fri Feb 09 00:00:00 UTC 2007
Mechanistic link between PKR dimerization, autophosphorylation, and eIF2alpha substrate recognition.
Cell
Dey M,Cao C,Dar AC,Tamura T,Ozato K,Sicheri F,Dever TE
Fri Sep 23 00:00:00 UTC 2005
Human cytomegalovirus TRS1 and IRS1 gene products block the double-stranded-RNA-activated host protein shutoff response induced by herpes simplex virus type 1 infection.
Journal of virology
Cassady KA
44-728G was used in western blot to elucidate how human cytomegalovirus evades PKR-mediated protein shutoff and maintains late viral protein synthesis
Fri Jul 01 00:00:00 UTC 2005
Silencing gene expression with Dicer-generated siRNA pools.
Methods in molecular biology (Clifton, N.J.)
Myers JW,Ferrell JE
44-728G was used in Inhibition Assays to demonstrate the high specificity of nucleotide base-pairing ensures precise and efficient siRNA-mediated gene silencing.
Tue Sep 27 00:00:00 UTC 2005
Growth arrest and DNA damage-inducible protein GADD34 targets protein phosphatase 1 alpha to the endoplasmic reticulum and promotes dephosphorylation of the alpha subunit of eukaryotic translation initiation factor 2.
Molecular and cellular biology
Brush MH,Weiser DC,Shenolikar S
Sat Feb 01 00:00:00 UTC 2003
Growth arrest and DNA damage-inducible protein GADD34 targets protein phosphatase 1 alpha to the endoplasmic reticulum and promotes dephosphorylation of the alpha subunit of eukaryotic translation initiation factor 2.
Molecular and cellular biology
Brush MH,Weiser DC,Shenolikar S
Sat Feb 01 00:00:00 UTC 2003
