Invitrogen

Phospho-ETS1 (Ser251) Polyclonal Antibody

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Datasheet
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Datasheet
Protocols
Questions & Answers

Product Details

PA5-118739

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:3,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human ETS1(Accession P14921), corresponding to amino acid residues around phosphorylated Ser251.
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

sequential chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2903239

Product Specific Information

Antibody detects endogenous levels of ETS1 only when phosphorylated at Ser251.

Target Information

ETS1 (c-Ets-1; v-ets erythroblastosis virus E26 oncogene homlog 1 (avian); ETS-1; EWSR2; p54), a 441 A. A protein, is a member of DNA-binding ETS protein family. It is a multifunctional protein consisting of an N-terminal pointed domain, a central transactivation domain and 2 auto inhibitory domains flanked on both sides of conserved C-terminal Ets domain. It interacts with factors including PEBP2alphaA, p300/CBP and mediates transactivation of Osteopontin, Presenilin-1, Stromelysin and Collagenase. It is activated by Ras/MAPK signaling and its expression is up-regulated in resting T-cells. Its activity is modulated by various factors including AP-1, Sp-1, c-myb and MafB. Sp100 activates ETS1 in nuclear bodies. It interacts with EAP1/Daxx and causes repression of MMP1 and BCL2 transactivation. It interacts with STAT6 and modulates Socs-1 expression induced by IL-4. It interacts with GATA3 and positively regulates Tax-1 dependent IL-5 expression.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Avian erythroblastosis virus E26 (v-ets) oncogene homolog-1; avian erythroblastosis virus E26 oncogene 1; Ets avian erythroblastosis virus E2 oncogene homolog 1 (tumor progression locus 1); ets protein; Ets-1Delta(III-VI); FLJ10768; p54; Protein C-ets-1; tumor progression locus 1; v-ets avian erythroblastosis virus E2 oncogene homolog 1; v-ets avian erythroblastosis virus E26 oncogene homolog 1; v-ets erythroblastosis virus E26 oncogene homolog 1

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Gene Aliases: AI196000; AI448617; c-ets-1; D230050P06; ETS-1; ETS1; Etsoncb; EWSR2; p54; Tpl1

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UniProt ID: (Human) P14921, (Rat) P41156, (Mouse) P27577

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Entrez Gene ID: (Human) 2113, (Rat) 24356, (Mouse) 23871

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Function(s)
RNA polymerase II transcription factor activity, sequence-specific DNA binding transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding transcription factor binding histone acetyltransferase binding identical protein binding sequence-specific DNA binding
Process(es)
response to hypoxia immune system process regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter female pregnancy positive regulation of cell proliferation response to wounding response to mechanical stimulus positive regulation of endothelial cell migration regulation of extracellular matrix disassembly hypothalamus development pituitary gland development cell differentiation positive regulation of cell migration PML body organization response to estradiol response to laminar fluid shear stress regulation of apoptotic process estrous cycle positive regulation of erythrocyte differentiation regulation of angiogenesis positive regulation of angiogenesis negative regulation of cell cycle positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter response to antibiotic cell motility positive regulation of cellular component movement angiogenesis involved in wound healing cellular response to hydrogen peroxide response to interleukin-1 transcription, DNA-templated regulation of transcription, DNA-templated immune response negative regulation of cell proliferation negative regulation of inflammatory response positive regulation of inflammatory response pri-miRNA transcription from RNA polymerase II promoter positive regulation of leukocyte adhesion to vascular endothelial cell
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