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Invitrogen
Phospho-EphA2/EphA3/EphA4 (Tyr588, Tyr596) Polyclonal Antibody
Product Details
PA5-37811
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide sequence around phosphorylation site of tyrosine 588/596 (K-T-Y(p)-V-R)/(R-T-Y(p)-V-D) derived from Human EPHA2/3/4.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2554419
Product Specific Information
A suggested positive control for Western blot is HepG2 cells; suggested positive control for ICC/IF is Hela cells.
Target Information
The Eph subfamily represents the largest group of receptor protein tyrosine kinases identified to date. While the biological activities of these receptors have yet to be determined, there is increasing evidence that they are involved in central nervous system function and in development. The Eph subfamily receptors of human origin (and their murine/avian homologs) include EphA1(Eph), EphA2 (Eck), EphA3 (Hek4), EphA4 (Hek8), EphA5 (Hek7), EphA6 (Hek12),EphA7 (Hek11/MDK1), EphA8 (Hek3), EphB1 (Hek6), EphB2 (Hek5), EphB3(Cek10, Hek2), EphB4 (Htk), EphB5 (Hek9) and EphB6 (Mep). Ligands for Eph receptors include ephrin-A4 (LERK-4) which binds EphA3 and EphB1. In addition, Ephrin-A2 (Elf-1) has been described as the ligand for EphA4, ephrin-A3 (Ehk1-L) as the ligand for EphA5 and ephrin-B2 (Htk-L) as the ligand for EphB4 (Htk).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: EK4; EK8; EPH-like kinase 4; EPH-like kinase 8; Eph-like tyrosine kinase 1; Ephrin A2; Ephrin A3; Ephrin A4; Ephrin type-A receptor 2; Ephrin type-A receptor 3; Ephrin type-A receptor 4; EphrinA2; EphrinA3; EphrinA4; Epithelial cell kinase; epithelial cell receptor protein tyrosine kinase; HEK; Human embryo kinase; human embryo kinase 1; receptor protein-tyrosine kinase HEK8; soluble EPHA2 variant 1; testicular tissue protein Li 64; TYRO1 protein tyrosine kinase; TYRO4 protein tyrosine kinase; Tyrosine-protein kinase receptor ECK; Tyrosine-protein kinase receptor ETK1; Tyrosine-protein kinase receptor MPK-3; Tyrosine-protein kinase receptor MPK-5; Tyrosine-protein kinase receptor SEK; Tyrosine-protein kinase receptor SEK-1; Tyrosine-protein kinase receptor SEK-2; Tyrosine-protein kinase TYRO1; Tyrosine-protein kinase TYRO4
Gene Aliases: 2900005C20Rik; AI385584; ARCC2; AW492086; AW545284; Cek4; Cek8; CTPA; CTPP1; CTRCT6; ECK; EK4; End3; EPHA2; EPHA3; EPHA4; ETK; ETK1; HEK; HEK4; HEK8; Mek4; Myk2; rb; SEK; Sek-2; Sek1; Sek2; TYRO1; TYRO4
UniProt ID: (Human) P29317, (Human) P29320, (Human) P54764, (Mouse) Q03145, (Mouse) Q03137
Entrez Gene ID: (Human) 1969, (Human) 2042, (Human) 2043, (Mouse) 13836, (Mouse) 13837, (Mouse) 13838
transmembrane receptor protein tyrosine kinase activity
ephrin receptor activity
protein binding
ATP binding
cadherin binding involved in cell-cell adhesion
GPI-linked ephrin receptor activity
protein kinase activity
transmembrane-ephrin receptor activity
PH domain binding
identical protein binding
ephrin receptor binding
DH domain binding
nucleotide binding
protein tyrosine kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
cell adhesion
regulation of epithelial to mesenchymal transition
positive regulation of neuron projection development
cell migration
peptidyl-tyrosine phosphorylation
regulation of actin cytoskeleton organization
regulation of GTPase activity
ephrin receptor signaling pathway
regulation of focal adhesion assembly
regulation of microtubule cytoskeleton organization
cellular response to retinoic acid
fasciculation of sensory neuron axon
fasciculation of motor neuron axon
skeletal system development
angiogenesis
blood vessel development
vasculogenesis
osteoblast differentiation
protein phosphorylation
apoptotic process
transmembrane receptor protein tyrosine kinase signaling pathway
intrinsic apoptotic signaling pathway in response to DNA damage
regulation of lamellipodium assembly
notochord formation
phosphorylation
neural tube development
cell differentiation
neuron differentiation
keratinocyte differentiation
osteoclast differentiation
mammary gland epithelial cell proliferation
regulation of cell adhesion mediated by integrin
post-anal tail morphogenesis
protein kinase B signaling
regulation of blood vessel endothelial cell migration
regulation of angiogenesis
bone remodeling
axial mesoderm formation
notochord morphogenesis
negative regulation of protein kinase B signaling
notochord cell development
cell chemotaxis
branching involved in mammary gland duct morphogenesis
lens fiber cell morphogenesis
regulation of ERK1 and ERK2 cascade
response to growth factor
positive regulation of establishment of protein localization to plasma membrane
activation of GTPase activity
endocardial cushion development
motor neuron axon guidance
multicellular organism development
nervous system development
axon guidance
adult walking behavior
glial cell migration
corticospinal tract morphogenesis
positive regulation of JUN kinase activity
protein autophosphorylation
negative regulation of axon regeneration
regulation of astrocyte differentiation
regulation of axonogenesis
positive regulation of dendrite morphogenesis
regulation of dendritic spine morphogenesis
nephric duct morphogenesis
positive regulation of Rho guanyl-nucleotide exchange factor activity
viral process
cell-cell adhesion
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