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Invitrogen
Phospho-EphA2/EphA5 (Tyr594) Polyclonal Antibody
Product Details
PA5-37812
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide sequence around phosphorylation site of tyrosine 594 (H-T-Y(p)-E-D) derived from Human EPHA2/5.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2554420
Product Specific Information
A suggested positive control for Western blot is JK cells.
Target Information
These proteins belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Brain-specific kinase; CEK-7; eck-like sequence 1; EHK-1; EK7; EPH homology kinase 1; EPH-like kinase 7; Ephrin A2; Ephrin A5; Ephrin type-A receptor 2; Ephrin type-A receptor 5; EphrinA2; EphrinA5; Epithelial cell kinase; epithelial cell receptor protein tyrosine kinase; receptor protein-tyrosine kinase HEK7; soluble EPHA2 variant 1; Tyrosine-protein kinase receptor ECK; tyrosine-protein kinase receptor EHK-1; Tyrosine-protein kinase receptor MPK-5; Tyrosine-protein kinase receptor SEK-2
Gene Aliases: AI854630; ARCC2; AW125296; AW545284; BSK; CEK7; CTPA; CTPP1; CTRCT6; ECK; EHK-1; EHK1; EK7; Els1; EPHA2; EPHA5; HEK7; Myk2; Rek7; Sek-2; Sek2; TYRO4
UniProt ID: (Human) P29317, (Human) P54756, (Mouse) Q03145, (Mouse) Q60629
Entrez Gene ID: (Human) 1969, (Human) 2044, (Mouse) 13836, (Mouse) 13839
transmembrane receptor protein tyrosine kinase activity
ephrin receptor activity
protein binding
ATP binding
cadherin binding involved in cell-cell adhesion
GPI-linked ephrin receptor activity
transmembrane-ephrin receptor activity
nucleotide binding
protein kinase activity
protein tyrosine kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
growth factor receptor binding
skeletal system development
angiogenesis
blood vessel development
vasculogenesis
osteoblast differentiation
protein phosphorylation
apoptotic process
cell adhesion
transmembrane receptor protein tyrosine kinase signaling pathway
intrinsic apoptotic signaling pathway in response to DNA damage
regulation of lamellipodium assembly
notochord formation
phosphorylation
cell migration
peptidyl-tyrosine phosphorylation
neural tube development
cell differentiation
neuron differentiation
keratinocyte differentiation
osteoclast differentiation
mammary gland epithelial cell proliferation
regulation of cell adhesion mediated by integrin
post-anal tail morphogenesis
protein kinase B signaling
regulation of blood vessel endothelial cell migration
regulation of angiogenesis
bone remodeling
ephrin receptor signaling pathway
axial mesoderm formation
notochord morphogenesis
negative regulation of protein kinase B signaling
notochord cell development
cell chemotaxis
branching involved in mammary gland duct morphogenesis
lens fiber cell morphogenesis
regulation of ERK1 and ERK2 cascade
response to growth factor
positive regulation of establishment of protein localization to plasma membrane
activation of GTPase activity
nervous system development
axon guidance
positive regulation of phosphatidylinositol 3-kinase signaling
cAMP-mediated signaling
hippocampus development
positive regulation of CREB transcription factor activity
regulation of actin cytoskeleton organization
regulation of GTPase activity
negative regulation of synapse assembly
dendritic spine morphogenesis
regulation of insulin secretion involved in cellular response to glucose stimulus
multicellular organism development
viral process
cell-cell adhesion
neuron development
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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