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Invitrogen
Phospho-EphA2 (Tyr930) Polyclonal Antibody
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Phospho-EphA2 (Tyr930) Antibody (PA5-64784) in WB
iScience 2022 -
The flexible juxtamembrane segment is required for EphA2 autophosphorylation HEK293 cells stably transfected with EGFP as a control, EphA2 WT or the EphA2 juxtamembrane deletion mutantsDeltaQ565-L582 (Deltajxtm-1) and DeltaQ565-T606 (Deltajxtm-2) were treated for 2.5 min with saturating concentrations of (A) ephrinA1-Fc, (B) dimer ( 2 ), (C) dimer ( 6 ) and (D) dimer ( 8 ). Lysates were probed by immunoblot... View More
Product Details
PA5-64784
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human EPHA2 (Phospho-Tyr930)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2663147
Product Specific Information
Phospho-EphA2 (Tyr930) Polyclonal Antibody detects endogenous levels of EphA2 only when phosphorylated at Tyr930.
Target Information
EPHA2 belongs to the ephrin receptor subfamily of the protein tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediated developmental events, particularly in the nervous system. EPHA2 is overexpressed in many types of human cancers. The tyrosine kinase (TK) group is mainly involved in the regulation of cell-cell interactions such as differentiation, adhesion, motility and death. There are currently about 90 TK genes sequenced, 58 are of receptor protein TK (e.g. EGFR, EPH, FGFR, PDGFR, TRK, and VEGFR families), and 32 of cytosolic TK (e.g. ABL, FAK, JAK, and SRC families).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Ephrin type-A receptor 2; Epithelial cell kinase; epithelial cell receptor protein tyrosine kinase; soluble EPHA2 variant 1; Tyrosine-protein kinase receptor ECK; Tyrosine-protein kinase receptor MPK-5; Tyrosine-protein kinase receptor SEK-2
Gene Aliases: ARCC2; AW545284; CTPA; CTPP1; CTRCT6; ECK; EPHA2; Myk2; Sek-2; Sek2
UniProt ID: (Human) P29317, (Mouse) Q03145
Entrez Gene ID: (Human) 1969, (Mouse) 13836
transmembrane receptor protein tyrosine kinase activity
ephrin receptor activity
protein binding
ATP binding
cadherin binding involved in cell-cell adhesion
nucleotide binding
protein kinase activity
protein tyrosine kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
skeletal system development
angiogenesis
blood vessel development
vasculogenesis
osteoblast differentiation
protein phosphorylation
apoptotic process
cell adhesion
transmembrane receptor protein tyrosine kinase signaling pathway
intrinsic apoptotic signaling pathway in response to DNA damage
regulation of lamellipodium assembly
notochord formation
phosphorylation
cell migration
peptidyl-tyrosine phosphorylation
neural tube development
cell differentiation
neuron differentiation
keratinocyte differentiation
osteoclast differentiation
mammary gland epithelial cell proliferation
regulation of cell adhesion mediated by integrin
post-anal tail morphogenesis
protein kinase B signaling
regulation of blood vessel endothelial cell migration
regulation of angiogenesis
bone remodeling
ephrin receptor signaling pathway
axial mesoderm formation
notochord morphogenesis
negative regulation of protein kinase B signaling
notochord cell development
cell chemotaxis
branching involved in mammary gland duct morphogenesis
lens fiber cell morphogenesis
regulation of ERK1 and ERK2 cascade
response to growth factor
positive regulation of establishment of protein localization to plasma membrane
activation of GTPase activity
multicellular organism development
viral process
cell-cell adhesion
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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