Invitrogen

Phospho-EphB Pan (Tyr600, Tyr602, Tyr614, Tyr596) Polyclonal Antibody

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-64578

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human EPHB1/2/3/4 (Phospho-Tyr600/602/614/596)
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2662980

Product Specific Information

Phospho-EphB Pan (Tyr600, Tyr602, Tyr614, Tyr596) Polyclonal Antibody detects endogenous levels of EphB Pan only when phosphorylated at Tyr600, Tyr602, Tyr614, Tyr596.

Target Information

Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. EphB4 binds to ephrin-B2 and plays an essential role in vascular development.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Developmental kinase 2; Developmental kinase 5; Developmentally-regulated Eph-related tyrosine kinase; EK2; EK5; EK6; ELK; ELK-related protein tyrosine kinase; ELK-related tyrosine kinase; Embryonic kinase 2; Eph receptor B2 (ELK-related protein tyrosine kinase); EPH receptor B4; EPH tyrosine kinase 2; EPH tyrosine kinase 3; EPH-like kinase 2; EPH-like kinase 5; EPH-like kinase 6; EPH-like tyrosine kinase 2; EPH-like tyrosine kinase-2; Ephrin B1; Ephrin B2; Ephrin B3; Ephrin B4; ephrin receptor EphB4; Ephrin type-B receptor 1; Ephrin type-B receptor 2; Ephrin type-B receptor 3; Ephrin type-B receptor 4; EphrinB1; EphrinB2; EphrinB3; EphrinB4; HEK-6; Hepatoma transmembrane kinase; human embryo kinase 2; mDK-2; mDK-5; MGC87492; NET; Neural kinase; Neuronally-expressed EPH-related tyrosine kinase; Nuk receptor tyrosine kinase; protein-tyrosine kinase HEK5; Renal carcinoma antigen NY-REN-47; soluble EPHB1 variant 1; soluble EPHB4 variant 1; soluble EPHB4 variant 2; soluble EPHB4 variant 3; Tyrosine kinase MYK-1; Tyrosine-protein kinase receptor EPH-2; Tyrosine-protein kinase receptor EPH-3; tyrosine-protein kinase receptor HTK; Tyrosine-protein kinase receptor SEK-3; Tyrosine-protein kinase receptor SEK-4; Tyrosine-protein kinase TYRO11; Tyrosine-protein kinase TYRO5; Tyrosine-protein kinase TYRO6

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Gene Aliases: 9330129L11; AI042935; AW456895; AW488255; C130099E04Rik; CAPB; Cek10; Cek5; Cek6; DRT; EK2; EK5; ELK; Elkh; ENSMUSG00000074119; EPHB1; EPHB2; EPHB3; EPHB4; EPHT2; EPHT3; Epth2; EPTH3; ERK; ETECK; ETK2; HEK2; HEK5; HEK6; HTK; MDK2; MDK5; MYK1; NET; Nuk; PCBC; Prkm5; Qek5; RGD1564232; Sek3; Sek4; TYRO11; TYRO5; TYRO6

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UniProt ID: (Human) P54762, (Human) P29323, (Human) P54753, (Human) P54760, (Rat) P09759, (Mouse) Q8CBF3, (Mouse) P54763, (Mouse) P54754, (Mouse) P54761

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Entrez Gene ID: (Human) 2047, (Human) 2048, (Human) 2049, (Human) 2050, (Rat) 24338, (Mouse) 270190, (Mouse) 13844, (Rat) 313633, (Mouse) 13845, (Rat) 287989, (Rat) 686310, (Mouse) 13846

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Function(s)
transmembrane-ephrin receptor activity protein binding ATP binding axon guidance receptor activity protein complex binding protein tyrosine kinase activity receptor binding identical protein binding ephrin receptor activity transmembrane receptor protein tyrosine kinase activity nucleotide binding protein kinase activity kinase activity transferase activity transferase activity, transferring phosphorus-containing groups receptor activity molecular_function
Process(es)
angiogenesis immunological synapse formation axon guidance peptidyl-tyrosine phosphorylation cranial nerve development optic nerve morphogenesis central nervous system projection neuron axonogenesis neurogenesis establishment of cell polarity retinal ganglion cell axon guidance cell-substrate adhesion regulation of JNK cascade protein autophosphorylation ephrin receptor signaling pathway camera-type eye morphogenesis detection of temperature stimulus involved in sensory perception of pain positive regulation of synapse assembly cell chemotaxis dendritic spine development dendritic spine morphogenesis neural precursor cell proliferation regulation of ERK1 and ERK2 cascade regulation of neuron death protein phosphorylation cell adhesion transmembrane receptor protein tyrosine kinase signaling pathway nervous system development phosphorylation cell migration involved in sprouting angiogenesis heart morphogenesis urogenital system development axonal fasciculation cell migration corpus callosum development regulation of cell-cell adhesion substrate adhesion-dependent cell spreading regulation of GTPase activity thymus development digestive tract morphogenesis regulation of axonogenesis palate development learning inner ear morphogenesis positive regulation of long-term neuronal synaptic plasticity negative regulation of axonogenesis regulation of body fluid levels commissural neuron axon guidance cell morphogenesis multicellular organism development organ morphogenesis regulation of neuronal synaptic plasticity signal transduction biological_process
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