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Invitrogen
Phospho-EphB3 (Tyr608) Polyclonal Antibody
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Phospho-EphB3 (Tyr608) Antibody (PA5-64791) in WB
The Journal of biological chemistry 2022 -
Figure 1 ADAM9 cleaves ephrin-B1 and -B2 and can substitute for Xenopus ADAM13 in neural crest induction. A and B , HEK293T cells were transfected with plasmids encoding N-terminally HA-tagged ephrin-B1 (A) or -B2 ( B ) and C-terminally myc-tagged WT ADAM9 or the E348A mutant, and Western blotting was carried out using the indicated antibodies. Arrowheads point to the shed ectodomain of ephrin-Bs. C and D ,... View More
Product Details
PA5-64791
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human EPHB3 (Phospho-Tyr608)
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 30% glycerol
Contains
0.01% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2662981
Product Specific Information
Phospho-EphB3 (Tyr608) Polyclonal Antibody detects endogenous levels of EphB3 only when phosphorylated at Tyr608.
Target Information
EPHB3 is a receptor tyrosine kinase that belongs to the ephrin receptor family. Members of the Eph family of kinases play important roles in diverse biological processes including nervous system development, angiogenesis and neural synapsis formation and maturation. The ephrin ligands and Eph receptors display reciprocal expression in vivo. Developing and adult neural tissue express nearly all of the Eph receptors and ephrin ligands. Ephs and ephrins play a significant role in angiogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Developmental kinase 5; EK2; Embryonic kinase 2; EPH-like kinase 2; EPH-like tyrosine kinase 2; Ephrin type-B receptor 3; human embryo kinase 2; mDK-5; Tyrosine-protein kinase receptor SEK-4; Tyrosine-protein kinase TYRO6
Gene Aliases: AW456895; Cek10; EK2; EPHB3; ETK2; HEK2; MDK5; Sek4; TYRO6
UniProt ID: (Human) P54753, (Mouse) P54754
Entrez Gene ID: (Human) 2049, (Mouse) 13845
ephrin receptor activity
ATP binding
axon guidance receptor activity
nucleotide binding
protein kinase activity
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
transmembrane-ephrin receptor activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
angiogenesis
urogenital system development
axon guidance
axonal fasciculation
cell migration
peptidyl-tyrosine phosphorylation
central nervous system projection neuron axonogenesis
corpus callosum development
regulation of cell-cell adhesion
retinal ganglion cell axon guidance
substrate adhesion-dependent cell spreading
regulation of GTPase activity
protein autophosphorylation
ephrin receptor signaling pathway
thymus development
digestive tract morphogenesis
regulation of axonogenesis
positive regulation of synapse assembly
palate development
dendritic spine development
dendritic spine morphogenesis
protein phosphorylation
signal transduction
transmembrane receptor protein tyrosine kinase signaling pathway
multicellular organism development
nervous system development
phosphorylation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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