Invitrogen

Phospho-ErbB2 (HER-2) (Tyr1221, Tyr1222) Polyclonal Antibody

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Datasheet
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Datasheet
Protocols
Questions & Answers

Product Details

PA5-40205

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (IHC)

1:100-1:300
-

Immunocytochemistry (ICC/IF)

5 µg/mL
-

Immunoprecipitation (IP)

2-5 µg/mg
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthesized peptide derived from human Neu around the phosphorylation site of Y1221/Y1222.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol, 0.5% BSA

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2609741

Product Specific Information

This antibody is predicted to react with mouse and rat based on sequence homology.

Target Information

ErbB2 (HER2) is a receptor tyrosine kinase that is overexpressed in some breast tumors. Herceptin, used in treatment of metastatic Her2-positive cancer, is monoclonal antibody targeting this kinase.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: avian erythroblastosis oncogene B 2; Avian erythroblastosis viral (v-erb-B2) oncogene homologue 2 (neuro/glioblastoma derived oncogene homolog); c-erb B2/neu protein; C-erbB-2; CD antigen CD340; CD340; epidermal growth factor receptor-related protein; erb-b2; erbb 2; ErbB2 (pTyr1139); ErbB2 (pY1139); ErbB2 phospho Y1139; her 2; herstatin; human epidermal growth factor receptor 2; metas; Metastatic lymph node gene 19 protein; MLN 19; Neu oncogene; NEU proto-oncogene; neuro/glioblastoma derived oncogene homolog; neuroblastoma/glioblastoma derived oncogene homolog; p185erbB2; p185neu; phospho ErbB2; Proto-oncogene c-ErbB-2; Proto-oncogene Neu; Receptor tyrosine-protein kinase erbB-2; Tyrosine kinase-type cell surface receptor HER2; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2; v-erb-b2 avian erythroblastic leukemia viral oncoprotein 2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog

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Gene Aliases: c-erbB2; c-neu; CD340; Erbb-2; ERBB2; HER-2; HER-2/neu; HER2; Kiaa3023; mKIAA3023; MLN 19; MLN19; NEU; NGL; TKR1

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UniProt ID: (Human) P04626, (Mouse) P70424

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Entrez Gene ID: (Human) 2064, (Mouse) 13866, (Rat) 24337

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Function(s)
RNA polymerase I core binding protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity receptor signaling protein tyrosine kinase activity transmembrane signaling receptor activity Ras guanyl-nucleotide exchange factor activity protein binding ATP binding protein C-terminus binding growth factor binding protein phosphatase binding identical protein binding ErbB-3 class receptor binding phosphatidylinositol-4,5-bisphosphate 3-kinase activity protein heterodimerization activity protein dimerization activity nucleotide binding glycoprotein binding protein kinase activity kinase activity transferase activity transferase activity, transferring phosphorus-containing groups ubiquitin protein ligase binding Hsp90 protein binding DNA binding
Process(es)
positive regulation of protein phosphorylation transcription, DNA-templated regulation of transcription, DNA-templated protein phosphorylation signal transduction cell surface receptor signaling pathway transmembrane receptor protein tyrosine kinase signaling pathway nervous system development peripheral nervous system development heart development neuromuscular junction development motor neuron axon guidance positive regulation of cell proliferation glial cell differentiation phosphatidylinositol 3-kinase signaling positive regulation of phosphatidylinositol 3-kinase signaling phosphorylation peptidyl-tyrosine phosphorylation positive regulation of cell growth regulation of microtubule-based process negative regulation of immature T cell proliferation in thymus wound healing myelination negative regulation of apoptotic process positive regulation of MAP kinase activity positive regulation of MAPK cascade positive regulation of GTPase activity estrous cycle positive regulation of translation positive regulation of cell adhesion positive regulation of transcription from RNA polymerase I promoter positive regulation of transcription from RNA polymerase III promoter positive regulation of Ras protein signal transduction protein autophosphorylation sympathetic nervous system development response to axon injury oligodendrocyte differentiation positive regulation of epithelial cell proliferation regulation of ERK1 and ERK2 cascade liver development central nervous system development skeletal muscle tissue development signal transduction by protein phosphorylation response to progesterone regulation of cell proliferation response to drug tongue development regulation of cell differentiation mammary gland involution MAPK cascade enzyme linked receptor protein signaling pathway cell proliferation regulation of phosphatidylinositol 3-kinase signaling ERBB2 signaling pathway regulation of angiogenesis phosphatidylinositol phosphorylation phosphatidylinositol-mediated signaling cellular response to growth factor stimulus cellular response to epidermal growth factor stimulus positive regulation of protein targeting to membrane regulation of cell motility
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