Invitrogen

Phospho-ErbB2 (HER-2) (Tyr1248) Recombinant Rabbit Monoclonal Antibody (HL1466)

Advanced Verification
View all (272) Her-2 (ErbB2) antibodies

Promotion

View available promotion(s)

Promo code: {{promo.promoCode}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

MA5-46898

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:3,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:1,000
-

Immunocytochemistry (ICC/IF)

Assay-dependent
-
Product Specifications

Species Reactivity

Human, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

HL1466

Immunogen

Carrier-protein conjugated synthetic peptide encompassing a sequence within the center region of human HER2 (phospho Tyr1248). The exact sequence is proprietary.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

PBS

Contains

no preservative

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2937970

Product Specific Information

Store as concentrated solution.

Centrifuge briefly prior to opening vial.

Target Information

ErbB2 (HER2) is a receptor tyrosine kinase that is overexpressed in some breast tumors. Herceptin, used in treatment of metastatic Her2-positive cancer, is monoclonal antibody targeting this kinase.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

References (0)

Have you cited this product in a publication?
Let us know so we can reference it here.
Cite this product

Bioinformatics

Protein Aliases: Avian erythroblastosis viral (v-erb-B2) oncogene homologue 2 (neuro/glioblastoma derived oncogene homolog); c-erb B2/neu protein; C-erbB-2; CD antigen CD340; CD340; epidermal growth factor receptor-related protein; erb-b2; erbb 2; ErbB2 (pTyr1139); ErbB2 (pY1139); ErbB2 phospho Y1139; her 2; herstatin; human epidermal growth factor receptor 2; metas; Metastatic lymph node gene 19 protein; MLN 19; NEU proto-oncogene; neuro/glioblastoma derived oncogene homolog; neuroblastoma/glioblastoma derived oncogene homolog; p185erbB2; p185neu; phospho ErbB2; Proto-oncogene c-ErbB-2; Proto-oncogene Neu; Receptor tyrosine-protein kinase erbB-2; Tyrosine kinase-type cell surface receptor HER2; v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2; v-erb-b2 avian erythroblastic leukemia viral oncoprotein 2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog

View more View less

Gene Aliases: CD340; ERBB2; HER-2; HER-2/neu; HER2; MLN 19; MLN19; NEU; NGL; TKR1

View more View less

UniProt ID: (Human) P04626

View more View less

Entrez Gene ID: (Human) 2064, (Rat) 24337

View more View less

Function(s)
RNA polymerase I core binding protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity receptor signaling protein tyrosine kinase activity transmembrane signaling receptor activity Ras guanyl-nucleotide exchange factor activity protein binding ATP binding protein C-terminus binding growth factor binding protein phosphatase binding identical protein binding ErbB-3 class receptor binding phosphatidylinositol-4,5-bisphosphate 3-kinase activity protein heterodimerization activity protein dimerization activity glycoprotein binding DNA binding ubiquitin protein ligase binding Hsp90 protein binding
Process(es)
liver development positive regulation of protein phosphorylation transcription, DNA-templated signal transduction cell surface receptor signaling pathway transmembrane receptor protein tyrosine kinase signaling pathway nervous system development central nervous system development peripheral nervous system development heart development skeletal muscle tissue development neuromuscular junction development motor neuron axon guidance positive regulation of cell proliferation glial cell differentiation phosphatidylinositol 3-kinase signaling positive regulation of phosphatidylinositol 3-kinase signaling peptidyl-tyrosine phosphorylation signal transduction by protein phosphorylation positive regulation of cell growth response to progesterone regulation of microtubule-based process negative regulation of immature T cell proliferation in thymus wound healing regulation of cell proliferation response to drug myelination negative regulation of apoptotic process positive regulation of MAP kinase activity positive regulation of MAPK cascade tongue development estrous cycle regulation of cell differentiation positive regulation of translation positive regulation of cell adhesion positive regulation of transcription from RNA polymerase I promoter positive regulation of transcription from RNA polymerase III promoter positive regulation of Ras protein signal transduction protein autophosphorylation sympathetic nervous system development response to axon injury oligodendrocyte differentiation positive regulation of epithelial cell proliferation mammary gland involution regulation of ERK1 and ERK2 cascade MAPK cascade protein phosphorylation enzyme linked receptor protein signaling pathway cell proliferation regulation of phosphatidylinositol 3-kinase signaling ERBB2 signaling pathway positive regulation of GTPase activity regulation of angiogenesis phosphatidylinositol phosphorylation phosphatidylinositol-mediated signaling cellular response to growth factor stimulus cellular response to epidermal growth factor stimulus positive regulation of protein targeting to membrane regulation of cell motility
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support