Invitrogen

Phospho-Ezrin/Radixin/Moesin (Thr558, Thr567, Thr564) Polyclonal Antibody

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-117253

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic phosphorylated peptide around T567 of human EZR/RDX/MSNEZR (NP_0033702)
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.17 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.01% thimerosal

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2901883

Product Specific Information

Positive Samples: PC-12

Immunogen sequence: YKTLR

Target Information

Moesin, a member of the talin-4.1 superfamily, is a linking protein of the submembraneous actin cytoskeleton. It is expressed in macrophages, lymphocytes, fibroblastic, endothelial, epithelial, and neuronal cell lines but not in blood cells. It is involved in cell adhesion, migration, and organization of cell surface structures.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Cytovillin; cytovillin 2; epididymis luminal protein 70; epididymis secretory protein Li 105; Ezrin; Membrane-organizing extension spike protein; Moesin; p81; Radixin; radixin isoform; villin 2; villin 2 (ezrin); Villin-2

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Gene Aliases: CVIL; CVL; DFNB24; EZR; HEL-S-105; HEL70; MSN; RDX; VIL2

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UniProt ID: (Human) P15311, (Rat) P31977, (Human) P26038, (Rat) O35763, (Human) P35241

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Entrez Gene ID: (Human) 7430, (Rat) 54319, (Human) 4478, (Rat) 81521, (Human) 5962, (Rat) 315655

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Function(s)
actin binding protein binding microtubule binding protein domain specific binding protein kinase A catalytic subunit binding protein kinase A regulatory subunit binding S100 protein binding poly(A) RNA binding cell adhesion molecule binding actin filament binding ATPase binding cadherin binding involved in cell-cell adhesion structural molecule activity protein complex binding double-stranded RNA binding receptor binding structural constituent of cytoskeleton protein kinase binding protein binding, bridging protein homodimerization activity protein kinase A binding
Process(es)
leukocyte cell-cell adhesion positive regulation of gene expression membrane to membrane docking leukocyte migration establishment of endothelial barrier regulation of lymphocyte migration microvillus assembly cellular response to platelet-derived growth factor stimulus apical protein localization barbed-end actin filament capping regulation of cell shape epithelial cell differentiation receptor internalization establishment or maintenance of apical/basal cell polarity establishment of epithelial cell apical/basal polarity filopodium assembly actin filament bundle assembly negative regulation of transcription from RNA polymerase II promoter intestinal D-glucose absorption sphingosine-1-phosphate signaling pathway cytoskeletal anchoring at plasma membrane axon guidance regulation of cell size protein kinase A signaling gland morphogenesis astral microtubule organization actin cytoskeleton reorganization regulation of microvillus length regulation of actin cytoskeleton organization cellular protein complex localization positive regulation of multicellular organism growth cortical microtubule organization phosphatidylinositol-mediated signaling positive regulation of protein secretion negative regulation of T cell receptor signaling pathway establishment of centrosome localization negative regulation of ERK1 and ERK2 cascade cellular response to cAMP protein localization to cell cortex establishment of protein localization to plasma membrane positive regulation of establishment of protein localization to plasma membrane negative regulation of interleukin-2 secretion regulation of NIK/NF-kappaB signaling regulation of organelle assembly terminal web assembly positive regulation of protein localization to early endosome positive regulation of cellular protein catabolic process negative regulation of p38MAPK cascade positive regulation of early endosome to late endosome transport positive regulation of cell migration regulation of actin filament bundle assembly regulation of Rap protein signal transduction negative regulation of homotypic cell-cell adhesion negative regulation of GTPase activity regulation of GTPase activity establishment of protein localization negative regulation of cell size actin filament capping cellular response to thyroid hormone stimulus cell-cell adhesion regulation of ruffle assembly positive regulation of G1/S transition of mitotic cell cycle negative regulation of adherens junction organization movement of cell or subcellular component cytoskeleton organization cellular response to testosterone stimulus positive regulation of podosome assembly
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