Invitrogen

Phospho-FER (Tyr497) Polyclonal Antibody

View all (22) FER antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-105506

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human FER(Accession P16591), corresponding to amino acid residues around phosphorylated Tyr497.
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

sequential chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2816934

Product Specific Information

Antibody detects endogenous levels of FER only when phosphorylated at Tyr497.

Target Information

FER is a member of the FPS/FES family of non-receptor tyrosine kinases. It regulates cell-cell adhesion and mediates signaling from the cell surface to the cytoskeleton via growth factor receptors. FER is found in the cytoplasm and in the nucleus, where it was associated with the chromatin fraction. Its ubiquitous expression and its subcellular location indicate that it may be involved in key regulatory processes. The group IV cytoplasmic protein-tyrosine kinase Fer has been linked to cellular signaling responses to many different stimuli, including growth factors and cytokines. Data suggest a biological role for Fer in regulation of leukocyte recruitment during the innate immune response.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: c-FER; EC 2.7.10.2; Feline encephalitis virus-related kinase FER; fer (fms/fps related) protein kinase, testis specific 2; fer (fps/fes related) tyrosine kinase; Fujinami poultry sarcoma/Feline sarcoma-related protein Fer; p47; p94-FER; phosphoprotein NCP94; protein phosphatase 1, regulatory subunit 74; Proto-oncogene c-Fer; proto-oncogene tyrosine-protein kinase FER; Tyrosine kinase 3; tyrosine protein kinase FLK; Tyrosine-protein kinase Fer; Tyrosine-protein kinase FLK

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Gene Aliases: AV082135; C330004K01Rik; FER; Fert; Fert2; Flk; Flk_retired; p94-Fer; PPP1R74; TYK3

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UniProt ID: (Human) P16591, (Mouse) P70451, (Rat) P09760

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Entrez Gene ID: (Human) 2241, (Mouse) 14158, (Rat) 301737

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Function(s)
protein tyrosine kinase activity non-membrane spanning protein tyrosine kinase activity epidermal growth factor receptor binding protein binding ATP binding protein phosphatase 1 binding lipid binding nucleotide binding actin binding protein kinase activity receptor binding cytoskeletal protein binding kinase activity transferase activity transferase activity, transferring phosphorus-containing groups Rab GTPase binding protein kinase binding gamma-catenin binding cadherin binding cell adhesion molecule binding
Process(es)
microtubule cytoskeleton organization mitotic cell cycle regulation of protein phosphorylation protein phosphorylation chemotaxis cell adhesion signal transduction cell proliferation regulation of lamellipodium assembly regulation of fibroblast migration phosphorylation peptidyl-tyrosine phosphorylation cytokine-mediated signaling pathway cell differentiation positive regulation of cell migration positive regulation of actin filament polymerization actin cytoskeleton reorganization response to lipopolysaccharide cellular response to insulin stimulus negative regulation of mast cell activation involved in immune response substrate adhesion-dependent cell spreading cellular response to reactive oxygen species extracellular matrix-cell signaling cellular response to macrophage colony-stimulating factor stimulus response to platelet-derived growth factor insulin receptor signaling pathway via phosphatidylinositol 3-kinase peptidyl-tyrosine autophosphorylation Fc-epsilon receptor signaling pathway Kit signaling pathway regulation of epidermal growth factor receptor signaling pathway regulation of cell proliferation tyrosine phosphorylation of Stat3 protein regulation of mast cell degranulation cell-cell adhesion mediated by cadherin innate immune response protein autophosphorylation platelet-derived growth factor receptor signaling pathway diapedesis positive regulation of NF-kappaB transcription factor activity interleukin-6-mediated signaling pathway epidermal growth factor receptor signaling pathway cell migration positive regulation of cell proliferation intracellular signal transduction
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