Hamburger Menu Button
Thermo Fisher Scientific Logo
Sign in
Don't have an account ? Create Account
  • Products
    • Antibodies
    • Cell Culture Media
    • Chemicals
    • Chromatography Columns and Cartridges
    • Lab Equipment
    • Lab Plasticware and Supplies
    • Microplates
    • Oligos, Primers, Probes and Genes
    • TaqMan Real-Time PCR Assays
    • Greener Products
    • See all product categories
  • Applications
    • Bioprocessing
    • Cell Culture and Transfection
    • Cell and Gene Therapy
    • Chromatography
    • Molecular Testing
    • Digital Solutions
    • DNA and RNA Extraction and Analysis
    • Spectroscopy, Elemental and Isotope Analysis
    • See all applications and techniques
  • Services
    • 360° CDMO and CRO Solutions
    • CDMO Services
    • CRO Services
    • Custom Services
    • Enterprise Services
    • Financial and Leasing Services
    • Instrument Services
    • Lab Informatics
    • OEM and Commercial Supply
    • Training Services
    • Unity Lab Services
    • See all services
  • Help and Support
    • How to Order
    • Instrument Support
    • Learning Centers
    • Register for an Account
    • Technical Support Centers
    • See all help and support topics
  • Popular
    • TaqMan Real-Time PCR Assays
      TaqMan Real-Time PCR Assays
    • Antibodies
      Antibodies
    • Oligos, Primers & Probes
      Oligos, Primers & Probes
    • GeneArt Gene Synthesis
      GeneArt Gene Synthesis
    • Cell Culture Plastics
      Cell Culture Plastics
  • Contact Us
  • Quick Order
  • Order Status and Tracking
  • Documents and Certificates
Thermo Fisher Scientific Logo

Search Thermo Fisher Scientific

Search All
Search button Close
          • Order Status
          • Quick Order
          • Sign in
            Sign in
            Don't have an account ? Create Account
            • Account
            • Check Order Status
            • Aspire Member Program
            • Connect: Lab, Data, Apps
            • Custom Products & Projects
            • Services Central

          Disclaimer

          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

          • Primary Antibodies ›
          • FGFR Pan Antibodies

          Invitrogen

          Phospho-FGFR Pan (Tyr653, Tyr654) Polyclonal Antibody

          2 References
          View all (2) FGFR Pan antibodies

          Promotion

          View available promotion(s)

          Promo code: {{promo.promoCode}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

          Datasheet
          Protocols
          Questions & Answers
          Datasheet
          Protocols
          Questions & Answers

          Cite Phospho-FGFR Pan (Tyr653, Tyr654) Polyclonal Antibody

          Product Details

          PA5-64626

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          1:1,000
          View 2 publications 2 publications
          Product Specifications

          Species Reactivity

          Human, Mouse, Rat

          Published species

          Human, Rat

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          A synthesized peptide derived from human FGFR1/2/3/4 (Phospho-Tyr653+Tyr654)
          View immunogen

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          1 mg/mL

          Purification

          Affinity chromatography

          Storage buffer

          PBS, pH 7.4, with 50% glycerol

          Contains

          0.02% sodium azide

          Storage conditions

          -20°C

          Shipping conditions

          Ambient (domestic); Wet ice (international)

          RRID

          AB_2662537

          Product Specific Information

          Phospho-FGFR Pan (Tyr653, Tyr654) Polyclonal Antibody detects endogenous levels of FGFR Pan only when phosphorylated at Tyr653, Tyr654.

          Target Information

          This gene encodes a protein that is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          Bioinformatics

          Protein Aliases: bacteria-expressed kinase; Basic fibroblast growth factor receptor 1; BEK fibroblast growth factor receptor; bFGF-R; bFGF-R-1; BFGFR; c-fgr; CD331; CD332; CD333; CD334; CTLA-2-beta protein; FGF receptor-1; fgfr 1; FGFR-1; FGFR-2; FGFR-3; FGFR-4; FGFR1/PLAG1 fusion; Fibroblast growth factor receptor 1; Fibroblast growth factor receptor 2; Fibroblast growth factor receptor 3; fibroblast growth factor receptor 3 variant 4; Fibroblast growth factor receptor 4; fibroblast growth factor receptor 4 16 minus form; FLT-2; FMS-like tyrosine kinase 2; fms-related tyrosine kinase 2; heparin-binding growth factor receptor; hydroxyaryl-protein kinase; K-sam; Keratinocyte growth factor receptor; KGFR; MFR; N-sam; protein tyrosine kinase, receptor like 14; protein-tyrosine kinase; Protein-tyrosine kinase receptor MPK-11; Proto-oncogene c-Fgr; tyrosine kinase JTK4; tyrosine kinase related to fibroblast growth factor receptor; tyrosylprotein kinase

          View more View less

          Gene Aliases: ACH; AU043015; AW208770; AW556123; BBDS; BEK; bFGF-R-1; BFGFR; BFR-1; c-fgr; CD331; CD332; CD333; CD334; CEK; CEK2; CEK3; CFD1; Eask; ECCL; ECT1; FGFBR; FGFR-1; Fgfr-2; Fgfr-3; Fgfr-4; Fgfr-7; FGFR1; FGFR2; FGFR3; FGFR4; Fgfr7; FLG; Flg-2; FLT-2; FLT2; FR3; HBGFR; HH2; HRTFDS; HSFGFR3EX; Hspy; JTK2; JTK4; JWS; K-SAM; KAL2; KGFR; KGFRTr; KSAM; MFR; Mfr3; Mpk-11; N-SAM; OGD; sam3; svs; TK14; TK25; TKF

          View more View less

          UniProt ID: (Human) P11362, (Human) P21802, (Human) P22607, (Human) P22455, (Rat) Q04589, (Mouse) P16092, (Mouse) P21803, (Rat) Q498D6, (Mouse) Q03142

          View more View less

          Entrez Gene ID: (Human) 2260, (Human) 2263, (Human) 2261, (Human) 2264, (Rat) 79114, (Mouse) 14182, (Mouse) 14183, (Rat) 25022, (Rat) 84489, (Mouse) 14184, (Rat) 25114, (Mouse) 14186

          View more View less

          Function(s)
          glycoprotein binding protein tyrosine kinase activity fibroblast growth factor-activated receptor activity Ras guanyl-nucleotide exchange factor activity protein binding ATP binding heparin binding 1-phosphatidylinositol-3-kinase activity fibroblast growth factor binding protein complex binding identical protein binding protein homodimerization activity phosphatidylinositol-4,5-bisphosphate 3-kinase activity cell adhesion molecule binding nucleotide binding protein kinase activity transmembrane receptor protein tyrosine kinase activity kinase activity transferase activity transferase activity, transferring phosphorus-containing groups growth factor activity
          Process(es)
          MAPK cascade positive regulation of cell proliferation fibroblast growth factor receptor signaling pathway positive regulation of gene expression regulation of extracellular matrix disassembly regulation of phosphatidylinositol 3-kinase signaling cell migration peptidyl-tyrosine phosphorylation regulation of lipid metabolic process phosphatidylinositol-3-phosphate biosynthetic process glucose homeostasis positive regulation of catalytic activity positive regulation of GTPase activity positive regulation of proteolysis protein autophosphorylation phosphatidylinositol phosphorylation phosphatidylinositol-mediated signaling phosphate ion homeostasis positive regulation of ERK1 and ERK2 cascade regulation of bile acid biosynthetic process response to bile acid regulation of cholesterol homeostasis positive regulation of DNA biosynthetic process negative regulation of transcription from RNA polymerase II promoter angiogenesis ureteric bud development in utero embryonic development epithelial to mesenchymal transition positive regulation of mesenchymal cell proliferation outflow tract septum morphogenesis membranous septum morphogenesis apoptotic process cell-cell signaling axonogenesis regulation of smoothened signaling pathway post-embryonic development embryonic pattern specification organ morphogenesis regulation of cell fate commitment positive regulation of phospholipase activity morphogenesis of embryonic epithelium orbitofrontal cortex development ventricular zone neuroblast division pyramidal neuron development gland morphogenesis positive regulation of Wnt signaling pathway bone mineralization lung development epithelial cell differentiation midbrain development otic vesicle formation hair follicle morphogenesis lacrimal gland development regulation of osteoblast proliferation multicellular organism growth organ growth fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow fibroblast growth factor receptor signaling pathway involved in hemopoiesis fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development regulation of multicellular organism growth regulation of fibroblast growth factor receptor signaling pathway inner ear morphogenesis odontogenesis positive regulation of MAPK cascade cell fate commitment regulation of osteoblast differentiation positive regulation of cell cycle positive regulation of transcription from RNA polymerase II promoter lung alveolus development mesodermal cell differentiation embryonic digestive tract morphogenesis embryonic organ morphogenesis digestive tract development embryonic organ development reproductive structure development positive regulation of smooth muscle cell proliferation embryonic cranial skeleton morphogenesis skeletal system morphogenesis epidermis morphogenesis branching morphogenesis of a nerve mesenchymal cell differentiation positive regulation of epithelial cell proliferation negative regulation of epithelial cell proliferation regulation of smooth muscle cell differentiation positive regulation of cell division ventricular cardiac muscle tissue morphogenesis positive regulation of cardiac muscle cell proliferation limb bud formation bone development bone morphogenesis branching involved in prostate gland morphogenesis branching involved in salivary gland morphogenesis bud elongation involved in lung branching lung lobe morphogenesis lung-associated mesenchyme development positive regulation of epithelial cell proliferation involved in lung morphogenesis prostate gland morphogenesis prostate epithelial cord elongation prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis squamous basal epithelial stem cell differentiation involved in prostate gland acinus development fibroblast growth factor receptor signaling pathway involved in mammary gland specification lateral sprouting from an epithelium mammary gland bud formation epithelial cell proliferation involved in salivary gland morphogenesis branch elongation involved in salivary gland morphogenesis branching involved in labyrinthine layer morphogenesis regulation of branching involved in prostate gland morphogenesis regulation of morphogenesis of a branching structure mesenchymal cell differentiation involved in lung development mesenchymal cell proliferation involved in lung development regulation of ERK1 and ERK2 cascade positive regulation of canonical Wnt signaling pathway skeletal system development endochondral ossification chondrocyte differentiation endochondral bone growth JAK-STAT cascade chondrocyte proliferation positive regulation of tyrosine phosphorylation of Stat1 protein positive regulation of tyrosine phosphorylation of Stat3 protein positive regulation of phosphatidylinositol 3-kinase activity negative regulation of developmental growth bone maturation fibroblast growth factor receptor apoptotic signaling pathway organ induction neuron migration transcription, DNA-templated protein phosphorylation sensory perception of sound positive regulation of phospholipase C activity positive regulation of neuron projection development positive regulation of phosphatidylinositol 3-kinase signaling stem cell population maintenance motogenic signaling involved in postnatal olfactory bulb interneuron migration embryonic limb morphogenesis neuron projection development outer ear morphogenesis middle ear morphogenesis chordate embryonic development positive regulation of MAP kinase activity regulation of cell differentiation positive regulation of neuron differentiation negative regulation of osteoblast differentiation paraxial mesoderm development regulation of lateral mesodermal cell fate specification cell maturation regulation of sensory perception of pain auditory receptor cell development regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling regulation of stem cell proliferation positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway positive regulation of endothelial cell chemotaxis to fibroblast growth factor regulation of extrinsic apoptotic signaling pathway in absence of ligand alveolar secondary septum development brain development salivary gland morphogenesis regulation of gene expression negative regulation of gene expression central nervous system neuron development regulation of cell proliferation blood vessel morphogenesis generation of neurons positive regulation of endothelial cell proliferation morphogenesis of an epithelium lens morphogenesis in camera-type eye negative regulation of cell proliferation oligodendrocyte development substantia nigra development central nervous system myelination cell differentiation forebrain development positive regulation of protein ubiquitination somatic stem cell population maintenance post-anal tail morphogenesis positive regulation of neuron apoptotic process positive regulation of cell differentiation negative regulation of mitotic nuclear division negative regulation of smoothened signaling pathway digestive tract morphogenesis response to axon injury negative regulation of astrocyte differentiation inner ear development positive regulation of peptidyl-tyrosine phosphorylation cartilage development inner ear receptor cell differentiation axonogenesis involved in innervation lens fiber cell development epithelial cell fate commitment cochlea development phosphorylation vasculogenesis involved in coronary vascular morphogenesis neuromuscular junction development synaptic vesicle transport epithelial cell proliferation regulation of epithelial cell proliferation coronal suture morphogenesis epithelial tube branching involved in lung morphogenesis endodermal digestive tract morphogenesis
          It has to be done as per old AB suggested Products section.
          guarantee_icon

          Performance Guarantee

          If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

          Learn more
          help_icon

          We're here to help

          Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

          Contact tech support
          Ordering Plus Icon Minus Icon
          • Order Status
          • Order Help
          • Quick Order
          • Supply Center
          • eProcurement
          Support Plus Icon Minus Icon
          • Help and Support
          • Contact Us
          • Technical Support Centers
          • Documents and Certificates
          • Report a Site Issue
          Resources Plus Icon Minus Icon
          • Learning Centers
          • Promotions
          • Events and Webinars
          • Social Media
          About Thermo Fisher Plus Icon Minus Icon
          • About Us
          • Careers
          • Investors
          • News
          • Social Responsibility
          • Trademarks
          • Consumer Health Data Privacy Policy
          Our Portfolio Plus Icon Minus Icon
          • Thermo Scientific
          • Applied Biosystems
          • Invitrogen
          • Gibco
          • Ion Torrent
          • Fisher Scientific
          • Unity Lab Services
          • Patheon
          • PPD
          • Terms & Conditions
          • Privacy Information Center
          • Price & Freight Policy
          © 2006-2025 Thermo Fisher Scientific Inc. All rights reserved. All trademarks are the property of Thermo Fisher Scientific and its subsidiaries unless otherwise specified.
          United States flag icon
          United States

          Your items have has been added!


          Host server : magellan-search-67c77f6dc7-n6nf2:80/100.66.135.186:80.
          git-commit: 545e792480003146e539d624bd2a21b51d198228
          git-url: https://github.com/thermofisher/magellan-search
          git-branch: release/2.31.0-2025.06.23-1.0