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          • Primary Antibodies ›
          • FGFR1/FGFR2 Antibodies

          Invitrogen

          Phospho-FGFR1/FGFR2 (Tyr730, Tyr733) Polyclonal Antibody

          View all (7) FGFR1/FGFR2 antibodies

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          Cite Phospho-FGFR1/FGFR2 (Tyr730, Tyr733) Polyclonal Antibody

          • Antibody Testing Data (4)
          Phospho-FGFR1/FGFR2 (Tyr730, Tyr733) Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Group 53 Created with Sketch.
          Phospho-FGFR1/FGFR2 (Tyr730, Tyr733) Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Group 53 Created with Sketch.

          FIGURE: 1 / 4

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          Phospho-FGFR1/FGFR2 (Tyr730, Tyr733) Antibody (PA5-105954) in IHC (P)

          Immunohistochemistry analysis of paraffin-embedded Phospho-FGFR1/FGFR2 (Tyr730, Tyr733) in mouse kidney tissue sections. Antigen retrieval was performed using citrate buffer. Samples were blocked with blocking buffer (1.5 hr, 22°C), incubated with Phospho-FGFR1/FGFR2 (Tyr730, Tyr733) polyclonal antibody (Product # PA5-105954) using a dilution of 1:200 (1.5 hr, 22°C), followed by HRP conjugated goat anti-rab... View More {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          Phospho-FGFR1/FGFR2 (Tyr730, Tyr733) Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Phospho-FGFR1/FGFR2 (Tyr730, Tyr733) Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Phospho-FGFR1/FGFR2 (Tyr730, Tyr733) Antibody in Immunohistochemistry (Paraffin) (IHC (P))
          Phospho-FGFR1/FGFR2 (Tyr730, Tyr733) Antibody in Western Blot (WB)

          Product Details

          PA5-105954

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          1:1,000-1:3,000
          -

          Immunohistochemistry (Paraffin) (IHC (P))

          1:50-1:200
          -

          Immunocytochemistry (ICC/IF)

          1:100-1:500
          -
          Product Specifications

          Species Reactivity

          Human, Mouse, Rat

          Host/Isotype

          Rabbit / IgG

          Class

          Polyclonal

          Type

          Antibody

          Immunogen

          A synthesized peptide derived from human FGFR1(Accession P11362), corresponding to amino acid residues around phosphorylated Tyr730.
          View immunogen

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Liquid

          Concentration

          1 mg/mL

          Purification

          sequential chromatography

          Storage buffer

          PBS, pH 7.4, with 50% glycerol

          Contains

          0.02% sodium azide

          Storage conditions

          -20°C

          Shipping conditions

          Ambient (domestic); Wet ice (international)

          RRID

          AB_2817353

          Product Specific Information

          Antibody detects endogenous levels of FGFR1/2 only when phosphorylated at Tyr730/733.

          Target Information

          FGFR1 is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          References (0)

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          Cite this product

          Bioinformatics

          Protein Aliases: bacteria-expressed kinase; Basic fibroblast growth factor receptor 1; BEK fibroblast growth factor receptor; bFGF-R; bFGF-R-1; BFGFR; c-fgr; CD331; CD332; FGF Receptor 2; FGF receptor-1; fgfr 1; FGFR-1; FGFR-2; FGFR1/PLAG1 fusion; Fibroblast growth factor receptor 1; Fibroblast growth factor receptor 2; FLT-2; FMS-like tyrosine kinase 2; fms-related tyrosine kinase 2; heparin-binding growth factor receptor; hydroxyaryl-protein kinase; K-sam; Keratinocyte growth factor receptor; KGFR; MFR; N-sam; protein tyrosine kinase, receptor like 14; Proto-oncogene c-Fgr; Soluble KGFR

          View more View less

          Gene Aliases: AU043015; AW208770; AW556123; BBDS; BEK; bFGF-R-1; BFGFR; BFR-1; c-fgr; CD331; CD332; CEK; CEK3; CFD1; Eask; ECCL; ECT1; FGFBR; FGFR-1; Fgfr-2; Fgfr-7; FGFR1; FGFR2; Fgfr7; FLG; FLT-2; FLT2; HBGFR; HH2; HRTFDS; Hspy; JWS; K-SAM; KAL2; KGFR; KGFRTr; KSAM; MFR; N-SAM; OGD; svs; TK14; TK25

          View more View less

          UniProt ID: (Human) P11362, (Human) P21802, (Rat) Q04589, (Mouse) P16092, (Mouse) P21803

          View more View less

          Entrez Gene ID: (Human) 2260, (Human) 2263, (Rat) 79114, (Mouse) 14182, (Mouse) 14183, (Rat) 25022

          View more View less

          Function(s)
          glycoprotein binding protein tyrosine kinase activity fibroblast growth factor-activated receptor activity Ras guanyl-nucleotide exchange factor activity protein binding ATP binding heparin binding 1-phosphatidylinositol-3-kinase activity fibroblast growth factor binding protein complex binding identical protein binding protein homodimerization activity phosphatidylinositol-4,5-bisphosphate 3-kinase activity cell adhesion molecule binding nucleotide binding protein kinase activity transmembrane receptor protein tyrosine kinase activity kinase activity transferase activity transferase activity, transferring phosphorus-containing groups
          Process(es)
          negative regulation of transcription from RNA polymerase II promoter MAPK cascade angiogenesis ureteric bud development in utero embryonic development epithelial to mesenchymal transition positive regulation of mesenchymal cell proliferation outflow tract septum morphogenesis membranous septum morphogenesis apoptotic process cell-cell signaling axonogenesis positive regulation of cell proliferation fibroblast growth factor receptor signaling pathway regulation of smoothened signaling pathway post-embryonic development embryonic pattern specification organ morphogenesis regulation of cell fate commitment positive regulation of phospholipase activity regulation of phosphatidylinositol 3-kinase signaling morphogenesis of embryonic epithelium peptidyl-tyrosine phosphorylation orbitofrontal cortex development ventricular zone neuroblast division pyramidal neuron development gland morphogenesis positive regulation of Wnt signaling pathway bone mineralization lung development epithelial cell differentiation midbrain development otic vesicle formation hair follicle morphogenesis lacrimal gland development regulation of osteoblast proliferation multicellular organism growth organ growth fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow fibroblast growth factor receptor signaling pathway involved in hemopoiesis fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development phosphatidylinositol-3-phosphate biosynthetic process regulation of multicellular organism growth regulation of fibroblast growth factor receptor signaling pathway inner ear morphogenesis odontogenesis positive regulation of MAPK cascade positive regulation of GTPase activity cell fate commitment regulation of osteoblast differentiation positive regulation of cell cycle positive regulation of transcription from RNA polymerase II promoter protein autophosphorylation phosphatidylinositol phosphorylation phosphatidylinositol-mediated signaling lung alveolus development mesodermal cell differentiation embryonic digestive tract morphogenesis embryonic organ morphogenesis digestive tract development embryonic organ development reproductive structure development positive regulation of smooth muscle cell proliferation embryonic cranial skeleton morphogenesis skeletal system morphogenesis epidermis morphogenesis branching morphogenesis of a nerve mesenchymal cell differentiation positive regulation of epithelial cell proliferation negative regulation of epithelial cell proliferation regulation of smooth muscle cell differentiation positive regulation of cell division ventricular cardiac muscle tissue morphogenesis positive regulation of cardiac muscle cell proliferation limb bud formation bone development bone morphogenesis branching involved in prostate gland morphogenesis branching involved in salivary gland morphogenesis bud elongation involved in lung branching lung lobe morphogenesis lung-associated mesenchyme development positive regulation of epithelial cell proliferation involved in lung morphogenesis prostate gland morphogenesis prostate epithelial cord elongation prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis squamous basal epithelial stem cell differentiation involved in prostate gland acinus development fibroblast growth factor receptor signaling pathway involved in mammary gland specification lateral sprouting from an epithelium mammary gland bud formation epithelial cell proliferation involved in salivary gland morphogenesis branch elongation involved in salivary gland morphogenesis branching involved in labyrinthine layer morphogenesis regulation of branching involved in prostate gland morphogenesis regulation of morphogenesis of a branching structure mesenchymal cell differentiation involved in lung development mesenchymal cell proliferation involved in lung development regulation of ERK1 and ERK2 cascade positive regulation of ERK1 and ERK2 cascade positive regulation of canonical Wnt signaling pathway skeletal system development organ induction neuron migration chondrocyte differentiation transcription, DNA-templated protein phosphorylation sensory perception of sound positive regulation of phospholipase C activity positive regulation of neuron projection development positive regulation of phosphatidylinositol 3-kinase signaling cell migration stem cell population maintenance motogenic signaling involved in postnatal olfactory bulb interneuron migration embryonic limb morphogenesis neuron projection development outer ear morphogenesis middle ear morphogenesis chordate embryonic development positive regulation of MAP kinase activity regulation of cell differentiation positive regulation of neuron differentiation negative regulation of osteoblast differentiation paraxial mesoderm development regulation of lateral mesodermal cell fate specification cell maturation regulation of sensory perception of pain auditory receptor cell development regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling regulation of stem cell proliferation positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway positive regulation of endothelial cell chemotaxis to fibroblast growth factor regulation of extrinsic apoptotic signaling pathway in absence of ligand brain development salivary gland morphogenesis regulation of gene expression negative regulation of gene expression central nervous system neuron development regulation of cell proliferation blood vessel morphogenesis generation of neurons phosphorylation vasculogenesis involved in coronary vascular morphogenesis neuromuscular junction development negative regulation of cell proliferation negative regulation of mitotic nuclear division synaptic vesicle transport epithelial cell proliferation regulation of epithelial cell proliferation coronal suture morphogenesis epithelial tube branching involved in lung morphogenesis endodermal digestive tract morphogenesis lens fiber cell development
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