Invitrogen

Phospho-FLT3 (Tyr969) Polyclonal Antibody

View all (47) FLT3 (CD135) antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-104593

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human FLT3(Accession P36888), corresponding to amino acid residues around phosphorylated Tyr969.
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

sequential chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2816068

Product Specific Information

Antibody detects endogenous levels of Flt3 / CD135 only when phosphorylated at Tyr969.

Target Information

FLT3 is a tyrosine protein kinase that is a member of the growth factor receptor tyrosine kinase family. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: CD135; CD135 antigen; Fetal liver kinase 2; Fetal liver kinase-2; FL cytokine receptor; FLK-2; FLT-3; Fms-like tyrosine kinase 3; fms-related tyrosine kinase 3; growth factor receptor tyrosine kinase type III; OTTHUMP00000214829; Receptor-type tyrosine-protein kinase FLT3; RP11-153M24.3; Stem cell tyrosine kinase 1; STK-1; tyrosine-protein kinase FLT3; Tyrosine-protein kinase receptor flk-2

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Gene Aliases: B230315G04; CD135; FLK-2; FLK2; Flt-3; FLT3; Ly72; STK1; wmfl

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UniProt ID: (Human) P36888, (Mouse) Q00342

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Entrez Gene ID: (Human) 2322, (Mouse) 14255

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Function(s)
transmembrane receptor protein tyrosine kinase activity cytokine receptor activity vascular endothelial growth factor-activated receptor activity protein binding ATP binding protein complex binding glucocorticoid receptor binding protein homodimerization activity nucleotide binding protein kinase activity protein tyrosine kinase activity kinase activity transferase activity transferase activity, transferring phosphorus-containing groups ubiquitin protein ligase binding phosphatidylinositol 3-kinase binding
Process(es)
leukocyte homeostasis positive regulation of protein phosphorylation myeloid progenitor cell differentiation lymphoid progenitor cell differentiation pro-B cell differentiation pro-T cell differentiation protein phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway negative regulation of cell proliferation phosphorylation peptidyl-tyrosine phosphorylation cytokine-mediated signaling pathway hemopoiesis lymphocyte differentiation cell differentiation B cell differentiation common myeloid progenitor cell proliferation negative regulation of B cell differentiation lymphocyte proliferation protein autophosphorylation cellular response to cytokine stimulus dendritic cell differentiation positive regulation of cell proliferation response to organonitrogen compound positive regulation of phosphatidylinositol 3-kinase signaling organ regeneration vascular endothelial growth factor signaling pathway positive regulation of tyrosine phosphorylation of STAT protein regulation of apoptotic process positive regulation of MAP kinase activity positive regulation of MAPK cascade positive regulation of phosphatidylinositol 3-kinase activity cellular response to glucocorticoid stimulus
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