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Invitrogen
Phospho-GABBR1 (Ser923) Polyclonal Antibody
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FIGURE: 1 / 1
Phospho-GABBR1 (Ser923) Antibody (PA1-4729) in WB
Western blot of GABBR1 in rat synaptic membrane lysate showing specific immunolabeling of a band at ~102 kDa corresponding to Phospho-GABBR1 (Ser923) polyclonal antibody (Product # PA1-4729) in the first lane (-). Phosphospecificity is shown in the second lane (+) where immunolabeling is completely eliminated by blot treatment with lambda phosphatase (1,200 units for 30 min).
Product Details
PA1-4729
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser923 of rat GABBR1 conjugated to KLH
Conjugate
Form
Liquid
Purification
Affinity chromatography
Storage buffer
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2247368
Product Specific Information
This antibody is predicted to react with bovine, human, mouse and non-human primate based on 100% sequence homology.
This antibody detects a band at ~102 kDa, representing GABAb R1 protein phosphorylated at Ser923.
Target Information
Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: bM573K1.1.1 (gamma-aminobutyric acid (GABA) B receptor, 1a); DAAP-188P13.3; dJ271M21.1.1; dJ271M21.1.2; FLJ92613; GABA(B) receptor; GABA-B receptor 1; GABA-B-R1; Gaba-b-r1a; Gaba-b1; GABA-BR1; Gaba-br1a receptor; GABA-BR1b receptor; GABAB; GABABR1; Gababr1 receptor; gamma-aminobutyric acid; gamma-aminobutyric acid (GABA-B) receptor, 1; Gamma-aminobutyric acid type B receptor subunit 1; gb1; GBR1; HGB1a; OTTHUMP00000109099; OTTHUMP00000214725
Gene Aliases: bM573K1.1; GABAB1; GABAbR1; Gabbr1
UniProt ID: (Mouse) Q9WV18, (Rat) Q9Z0U4
Entrez Gene ID: (Mouse) 54393, (Rat) 81657
osteoblast differentiation
signal transduction
G-protein coupled receptor signaling pathway
adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
negative regulation of adenylate cyclase activity
gamma-aminobutyric acid signaling pathway
negative regulation of cell proliferation
regulation of glutamate secretion
positive regulation of glutamate secretion
negative regulation of gamma-aminobutyric acid secretion
regulation of cAMP biosynthetic process
negative regulation of epinephrine secretion
negative regulation of dopamine secretion
negative regulation of synaptic transmission
positive regulation of growth hormone secretion
response to nicotine
response to ethanol
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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