Invitrogen

Phospho-GluR1 (Ser845) Polyclonal Antibody

1 Reference
View all (44) GluR1 antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-110124

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
View 1 publication 1 publication

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A phospho specific peptide corresponding to residues surrounding S845 of human GluR1/GRIA1
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.37 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.01% thimerosal

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2855535

Target Information

GluR1 (glutamate receptor 1) is an ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter, L-glutamate, induces a conformation change that leads to the opening of the cation channel and converts the chemical signal to an electrical impulse. Then, the receptor desensitizes rapidly and enters a transiet inactive state characterized by the presence of a bound agonist. In the presence of CACNG4, CACNG7, or CACNG8 GluR1 shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: AI853806; AMPA 1; AMPA-selective glutamate receptor 1; GluA1; GLUH 1; GluR K1; GluR-1; GluR-A; GluR-K1; GluR1; GluRK1; glutamate receptor; Glutamate receptor 1; glutamate receptor A; Glutamate receptor ionotropic, AMPA 1; glutamate receptor subunit GluR1; glutamate receptor, ionotropic, AMPA 1; glutamate receptor, ionotropic, AMPA1 (alpha 1); GPRC1A; Gria 1; GRM1A; HGBR1; HIPA; MGC13325; MGC133252; NMDA1; NMDAR1; NR1; OTTHUMP00000160643; OTTHUMP00000165781; OTTHUMP00000224241; OTTHUMP00000224242; OTTHUMP00000224243; RP11-350O14.1

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Gene Aliases: 2900051M01Rik; Glr-1; Glr1; GLUA1; GLUH1; Glur-1; GluR-A; gluR-K1; GLUR1; GLURA; GRIA1; HBGR1; HIPA1

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UniProt ID: (Human) P42261, (Rat) P19490, (Mouse) P23818

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Entrez Gene ID: (Human) 2890, (Rat) 50592, (Mouse) 14799

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Function(s)
AMPA glutamate receptor activity excitatory extracellular ligand-gated ion channel activity extracellular-glutamate-gated ion channel activity protein binding glutamate receptor activity PDZ domain binding G-protein alpha-subunit binding ionotropic glutamate receptor activity adenylate cyclase binding protein kinase binding protein domain specific binding small GTPase binding myosin V binding G-protein beta-subunit binding beta-2 adrenergic receptor binding identical protein binding protein homodimerization activity protein kinase A binding receptor activity ion channel activity
Process(es)
ER to Golgi vesicle-mediated transport signal transduction chemical synaptic transmission long-term memory receptor internalization ion transmembrane transport ionotropic glutamate receptor signaling pathway COPII vesicle coating long term synaptic depression regulation of receptor recycling response to toxic substance response to lithium ion response to organic cyclic compound neuronal action potential spinal cord development response to estradiol synaptic transmission, glutamatergic response to cocaine response to drug response to peptide hormone positive regulation of membrane potential response to arsenic-containing substance regulation of synaptic plasticity modulation of synaptic transmission positive regulation of synaptic transmission response to electrical stimulus response to fungicide cellular response to amino acid stimulus cellular response to dsRNA cellular response to growth factor stimulus cellular response to peptide hormone stimulus cellular response to organic cyclic compound cellular response to amine stimulus transport ion transport
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