Invitrogen

Phospho-HDAC4/HDAC5/HDAC7 (Ser246, Ser259, Ser155) Monoclonal Antibody (B.544.8)

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

MA5-14776

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-

ChIP assay (ChIP)

1-3 µL
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Monoclonal

Type

Antibody

Clone

B.544.8

Immunogen

Synthetic phosphopeptide corresponding to pSer155 of human HDAC7 protein
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Purification

Affinity chromatography

Storage buffer

0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol

Contains

<0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

RRID

AB_10980952

Product Specific Information

It is not recommended to aliquot this antibody.

Target Information

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to mouse HDAC7 gene whose protein promotes repression mediated via the transcriptional corepressor SMRT. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Antigen NY-CO-9; HD4; HD5; HD7; HD7a; hdac-7; Histone deacetylase 4; Histone deacetylase 5; Histone deacetylase 7; Histone deacetylase 7A; histone deacetylase A; histone deacetylase mHDA1; Protein deacetylase HDAC7

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Gene Aliases: 4932408F19Rik; 5830434K02Rik; AHO3; AI047285; AI426555; BDMR; HA6116; HD4; HD5; HD7; HD7A; HDAC-4; HDAC-A; HDAC4; HDAC5; HDAC7; HDAC7A; HDACA; KIAA0288; KIAA0600; mFLJ00062; mHDA1; mKIAA0600; NY-CO-9

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UniProt ID: (Human) P56524, (Human) Q9UQL6, (Human) Q8WUI4, (Mouse) Q6NZM9, (Mouse) Q8C2B3

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Entrez Gene ID: (Human) 9759, (Human) 10014, (Human) 51564, (Mouse) 208727, (Mouse) 15184, (Mouse) 56233

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Function(s)
RNA polymerase III transcription factor binding core promoter binding chromatin binding transcription corepressor activity histone deacetylase activity protein binding transcription factor binding zinc ion binding protein kinase binding potassium ion binding NAD-dependent histone deacetylase activity (H3-K14 specific) protein deacetylase activity activating transcription factor binding histone deacetylase binding sequence-specific DNA binding transcription regulatory region DNA binding repressing transcription factor binding protein kinase C binding metal ion binding SUMO transferase activity 14-3-3 protein binding DNA binding hydrolase activity histone deacetylase activity (H3-K14 specific) histone deacetylase activity (H3-K9 specific) histone deacetylase activity (H4-K16 specific) NAD-dependent histone deacetylase activity (H3-K9 specific) NAD-dependent histone deacetylase activity (H4-K16 specific) NAD-dependent histone deacetylase activity (H3-K18 specific) core promoter sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding RNA polymerase II transcription factor binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter skeletal system development osteoblast development chromatin remodeling transcription, DNA-templated inflammatory response nervous system development positive regulation of cell proliferation negative regulation of cell proliferation positive regulation of lamellipodium assembly negative regulation of myotube differentiation regulation of cardiac muscle contraction by calcium ion signaling response to denervation involved in regulation of muscle adaptation cardiac muscle hypertrophy in response to stress positive regulation of smooth muscle cell migration chromatin modification histone deacetylation B cell differentiation positive regulation of protein sumoylation peptidyl-lysine deacetylation regulation of gene expression, epigenetic B cell activation response to drug regulation of protein binding negative regulation of sequence-specific DNA binding transcription factor activity positive regulation of neuron apoptotic process negative regulation of osteoblast differentiation negative regulation of glycolytic process negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of smooth muscle cell proliferation regulation of skeletal muscle fiber development positive regulation of sequence-specific DNA binding transcription factor activity response to interleukin-1 histone H3 deacetylation histone H4 deacetylation cellular response to mechanical stimulus cellular response to tumor necrosis factor cellular response to parathyroid hormone stimulus positive regulation of reactive oxygen species biosynthetic process vasculogenesis regulation of transcription, DNA-templated cell-cell junction assembly negative regulation of interleukin-2 production negative regulation of striated muscle tissue development positive regulation of cell migration involved in sprouting angiogenesis negative regulation of neuron death protein sumoylation neuron differentiation neuron apoptotic process negative regulation of NIK/NF-kappaB signaling transcription from RNA polymerase II promoter protein deacetylation heart development negative regulation of gene expression regulation of myotube differentiation multicellular organismal response to stress response to cocaine regulation of striated muscle cell differentiation renal tubule morphogenesis cellular response to fluid shear stress negative regulation of cell migration involved in sprouting angiogenesis positive regulation of neural precursor cell proliferation positive regulation of stem cell proliferation chromatin organization chromatin silencing response to activity cellular response to insulin stimulus cellular response to lipopolysaccharide regulation of histone H3-K9 acetylation
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