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Invitrogen
Phospho-HIC5 (Tyr60) Polyclonal Antibody
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Phospho-HIC5 (Tyr60) Antibody (PA5-105804) in IHC (P)
Immunohistochemistry analysis of paraffin-embedded Phospho-HIC5 (Tyr60) in human breast tissue sections. Antigen retrieval was performed using citrate buffer. Samples were blocked with blocking buffer (1.5 hr, 22°C), incubated with Phospho-HIC5 (Tyr60) polyclonal antibody (Product # PA5-105804) using a dilution of 1:200 (1.5 hr, 22°C), followed by HRP conjugated goat anti-rabbit.
Product Details
PA5-105804
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human TGFB1I1(Accession O43294), corresponding to amino acid residues around phosphorylated Tyr60.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
sequential chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2817203
Product Specific Information
Antibody detects endogenous levels of Hic-5 only when phosphorylated at Tyr60.
Target Information
This gene encodes a coactivator of the androgen receptor, a transcription factor which is activated by androgen and has a key role in male sexual differentiation. The encoded protein is thought to regulate androgen receptor activity and may have a role to play in the treatment of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Androgen receptor coactivator 55 kDa protein; androgen receptor coactivator ARA55; Androgen receptor-associated protein of 55 kDa; Hic-5; Hydrogen peroxide-inducible clone 5 protein; hydrogen peroxide-inducible clone-5; TGF beta-stimulated clone 5; Transforming growth factor beta-1-induced transcript 1 protein; TSC-5
Gene Aliases: ARA55; HIC-5; HIC5; TGFB1I1; TSC-5
UniProt ID: (Human) O43294, (Mouse) Q62219, (Rat) Q99PD6
Entrez Gene ID: (Human) 7041, (Mouse) 21804, (Rat) 84574
response to heat
positive regulation of epithelial to mesenchymal transition
Wnt signaling pathway
morphogenesis of embryonic epithelium
cell differentiation
positive regulation of transforming growth factor beta receptor signaling pathway
negative regulation of transforming growth factor beta receptor signaling pathway
ubiquitin-dependent SMAD protein catabolic process
epithelial cell differentiation
cell fate commitment
negative regulation of fat cell differentiation
positive regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
cell adhesion
negative regulation of cell proliferation
androgen receptor signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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