Product References
Assessment of the Cytotoxicity, Mutagenicity, and Genotoxicity of Two Traditional Chinese Herbs: Aristolochia baetica and Magnolia officinalis.
Toxins
Poivre M,Antoine MH,Kryshen K,Atsapkina A,Shikov AN,Twyffels L,Nachtergael A,Duez P,Nortier J
MA1-2022 was used in ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot to evaluate on a human renal cell line, Aristolochia and Magnolia extracts for their cytotoxicity by a resazurin cell viability assay, and their genotoxicity by immunodetection and quantification of the phosphorylated histone ?-H2AX.
Fri Jan 06 00:00:00 UTC 2023
Foxm1 haploinsufficiency drives clonal hematopoiesis and promotes a stress-related transition to hematologic malignancy in mice.
The Journal of clinical investigation
Yu C,Sheng Y,Yu F,Ni H,Qiu A,Huang Y,Qian Z
MA1-2022 was used in Immunohistochemistry-immunofluorescence to demonstrate that Foxm1 haploinsufficiency disturbed normal hematopoiesis and conferred a competitive repopulation advantage for a short period.
Tue Aug 01 00:00:00 UTC 2023
YB1 modulates the DNA damage response in medulloblastoma.
Scientific reports
McSwain LF,Pillsbury CE,Haji-Seyed-Javadi R,Rath SK,Chen V,Huang T,Shahab SW,Kunhiraman H,Ross J,Price GA,Dey A,Hambardzumyan D,MacDonald T,Yu DS,Porter CC,Kenney AM
MA1-2022 was used in Western Blotting to show that depleting YB1 in combination with radiation sensitizes SHH and Group 3 MB cells to radiation.
Fri May 19 00:00:00 UTC 2023
YB1 modulates the DNA damage response in medulloblastoma.
Scientific reports
McSwain LF,Pillsbury CE,Haji-Seyed-Javadi R,Rath SK,Chen V,Huang T,Shahab SW,Kunhiraman H,Ross J,Price GA,Dey A,Hambardzumyan D,MacDonald T,Yu DS,Porter CC,Kenney AM
MA1-2022 was used in Western Blotting to show that depleting YB1 in combination with radiation sensitizes SHH and Group 3 MB cells to radiation.
Fri May 19 00:00:00 UTC 2023
Borna disease virus docks on neuronal DNA double-strand breaks to replicate and dampens neuronal activity.
iScience
Marty FH,Bettamin L,Thouard A,Bourgade K,Allart S,Larrieu G,Malnou CE,Gonzalez-Dunia D,Suberbielle E
MA1-2022 was used in Western Blot to decipher the interplay between Borna disease virus-1 infection and double-strand breaks, and to unravel its consequences on viral replication and neuronal function.
Fri Jan 21 00:00:00 UTC 2022
Borna disease virus docks on neuronal DNA double-strand breaks to replicate and dampens neuronal activity.
iScience
Marty FH,Bettamin L,Thouard A,Bourgade K,Allart S,Larrieu G,Malnou CE,Gonzalez-Dunia D,Suberbielle E
MA1-2022 was used in Western Blot to decipher the interplay between Borna disease virus-1 infection and double-strand breaks, and to unravel its consequences on viral replication and neuronal function.
Fri Jan 21 00:00:00 UTC 2022
Comparison of Different Clinical Chemotherapeutical Agents' Toxicity and Cell Response on Mesenchymal Stem Cells and Cancer Cells.
Cells
Vajda F,Szepesi Á,Várady G,Sessler J,Kiss D,Erdei Z,Szebényi K,Német K,Szakács G,Füredi A
MA1-2022 was used in Immunohistochemistry-immunofluorescence to suggest that MSCs and cancer cells have different cell fates after drug treatment, and this could influence therapy outcome.
Tue Sep 20 00:00:00 UTC 2022
3-deazaadenosine (3DA) alleviates senescence to promote cellular fitness and cell therapy efficiency in mice.
Nature aging
Guerrero A,Innes AJ,Roux PF,Buisman SC,Jung J,Ortet L,Moiseeva V,Wagner V,Robinson L,Ausema A,Potapova A,Perdiguero E,Weersing E,Aarts M,Martin N,Wuestefeld T,Muñoz-Cánoves P,de Haan G,Bischof O,Gil J
MA1-2022 was used in Immunocytochemistry to show that 3-deazaadenosine (3DA), an S-adenosyl homocysteinase (AHCY) inhibitor, alleviates replicative and oncogene-induced senescence.
Thu Sep 01 00:00:00 UTC 2022
PP4 inhibition sensitizes ovarian cancer to NK cell-mediated cytotoxicity via STAT1 activation and inflammatory signaling.
Journal for immunotherapy of cancer
Raja R,Wu C,Bassoy EY,Rubino TE,Utagawa EC,Magtibay PM,Butler KA,Curtis M
MA1-2022 was used in Immunocytochemistry to increased carboplatin sensitivity, DNA damage, and micronuclei formation.
Thu Dec 01 00:00:00 UTC 2022
Post-translational modification of RNA m6A demethylase ALKBH5 regulates ROS-induced DNA damage response.
Nucleic acids research
Yu F,Wei J,Cui X,Yu C,Ni W,Bungert J,Wu L,He C,Qian Z
MA1-2022 was used in Immunocytochemistry to uncover a molecular mechanism involving ALKBH5 PTMs and increased mRNA m6A levels that protect genomic integrity of cells in response to ROS.
Fri Jun 04 00:00:00 UTC 2021
Post-translational modification of RNA m6A demethylase ALKBH5 regulates ROS-induced DNA damage response.
Nucleic acids research
Yu F,Wei J,Cui X,Yu C,Ni W,Bungert J,Wu L,He C,Qian Z
MA1-2022 was used in Immunocytochemistry to uncover a molecular mechanism involving ALKBH5 PTMs and increased mRNA m6A levels that protect genomic integrity of cells in response to ROS.
Fri Jun 04 00:00:00 UTC 2021
Antibacterial and safety tests of a flexible cold atmospheric plasma device for the stimulation of wound healing.
Applied microbiology and biotechnology
Boekema B,Stoop M,Vlig M,van Liempt J,Sobota A,Ulrich M,Middelkoop E
Published figure using Phospho-Histone H2A.X (Ser139) monoclonal antibody (Product # MA1-2022) in Immunocytochemistry
Mon Mar 01 00:00:00 UTC 2021
Y2O3 Nanoparticles and X-ray Radiation-Induced Effects in Melanoma Cells.
Molecules (Basel, Switzerland)
Porosnicu I,Butnaru CM,Tiseanu I,Stancu E,Munteanu CVA,Bita BI,Duliu OG,Sima F
MA1-2022 was used in DNA Double-Strand Breaks Assay and Immunocytochemistry to investigate the effects of different doses of X-ray radiation and various concentrations of Yttrium oxide (Y2O3) nanoparticles (NPs) on melanoma cells, revealing alterations in mitochondrial activity, increased production of reactive oxygen species (ROS), and DNA damage when exposed to a combination of 50 µg/mL Y2O3 NPs and 6 Gy X-ray radiation.
Fri Jun 04 00:00:00 UTC 2021
Y2O3 Nanoparticles and X-ray Radiation-Induced Effects in Melanoma Cells.
Molecules (Basel, Switzerland)
Porosnicu I,Butnaru CM,Tiseanu I,Stancu E,Munteanu CVA,Bita BI,Duliu OG,Sima F
MA1-2022 was used in DNA Double-Strand Breaks Assay and Immunocytochemistry to investigate the effects of different doses of X-ray radiation and various concentrations of Yttrium oxide (Y2O3) nanoparticles (NPs) on melanoma cells, revealing alterations in mitochondrial activity, increased production of reactive oxygen species (ROS), and DNA damage when exposed to a combination of 50 µg/mL Y2O3 NPs and 6 Gy X-ray radiation.
Fri Jun 04 00:00:00 UTC 2021
CHK1 protects oncogenic KRAS-expressing cells from DNA damage and is a target for pancreatic cancer treatment.
Cell reports
Klomp JE,Lee YS,Goodwin CM,Papke B,Klomp JA,Waters AM,Stalnecker CA,DeLiberty JM,Drizyte-Miller K,Yang R,Diehl JN,Yin HH,Pierobon M,Baldelli E,Ryan MB,Li S,Peterson J,Smith AR,Neal JT,McCormick AK,Kuo CJ,Counter CM,Petricoin EF,Cox AD,Bryant KL,Der CJ
MA1-2022 was used in Immunocytochemistry-immunoflourescence to conclude that concurrent DDR suppression enhances the efficacy of ERK and/or autophagy inhibitors in KRAS mutant PDAC.
Tue Nov 30 00:00:00 UTC 2021
Cyclin F is involved in response to cisplatin treatment in melanoma cell lines.
Oncology reports
Krajewski A,Gagat M,Żuryń A,Hałas-Wiśniewska M,Grzanka D,Grzanka A
MA1-2022 was used in Flow Cytometry to investigate the difference between cyclin F expression in cell lines derived from primary and metastatic melanoma, A375 and RPMI‚7951.
Sun Mar 01 00:00:00 UTC 2020
Regulation of meiotic progression by Sertoli-cell androgen signaling.
Molecular biology of the cell
Larose H,Kent T,Ma Q,Shami AN,Harerimana N,Li JZ,Hammoud SS,Handel MA
MA1-2022 was used in Immunohistochemistry-immunofluorescence to demonstrate that SCARKO mutant spermatocytes exhibited normal expression and localization of key protein markers of meiotic prophase events, indicating that initiation of meiotic prophase is not androgen dependent.
Tue Dec 01 00:00:00 UTC 2020
Regulation of meiotic progression by Sertoli-cell androgen signaling.
Molecular biology of the cell
Larose H,Kent T,Ma Q,Shami AN,Harerimana N,Li JZ,Hammoud SS,Handel MA
MA1-2022 was used in Immunohistochemistry-immunofluorescence to demonstrate that SCARKO mutant spermatocytes exhibited normal expression and localization of key protein markers of meiotic prophase events, indicating that initiation of meiotic prophase is not androgen dependent.
Tue Dec 01 00:00:00 UTC 2020
Safety and bactericidal efficacy of cold atmospheric plasma generated by a flexible surface Dielectric Barrier Discharge device against Pseudomonas aeruginosa in vitro and in vivo.
Annals of clinical microbiology and antimicrobials
Dijksteel GS,Ulrich MMW,Vlig M,Sobota A,Middelkoop E,Boekema BKHL
MA1-2022 was used in Immunohistochemistry to determine the in vitro and in vivo safety and efficacy of cold atmospheric plasma generated by a surface Dielectric Barrier Discharge device.
Wed Aug 19 00:00:00 UTC 2020
"Mitotic Slippage" and Extranuclear DNA in Cancer Chemoresistance: A Focus on Telomeres.
International journal of molecular sciences
Salmina K,Bojko A,Inashkina I,Staniak K,Dudkowska M,Podlesniy P,Rumnieks F,Vainshelbaum NM,Pjanova D,Sikora E,Erenpreisa J
MA1-2022 was used in Western Blotting to explore mitotic slippage in the MDA-MB-231 cell line treated with doxorubicin.
Thu Apr 16 00:00:00 UTC 2020
Quantification of DNA Damage in Heart Tissue as a Novel Prediction Tool for Therapeutic Prognosis of Patients With Dilated Cardiomyopathy.
JACC. Basic to translational science
Ko T,Fujita K,Nomura S,Uemura Y,Yamada S,Tobita T,Katoh M,Satoh M,Ito M,Domoto Y,Hosoya Y,Amiya E,Hatano M,Morita H,Fukayama M,Aburatani H,Komuro I
MA1-2022 was used in Immunohistochemistry-immunofluorescence to develop a novel DNA-based prognosis prediction tool to assess the DNA damage in the heart tissue of patients with dilated cardiomyopathy.
Tue Oct 01 00:00:00 UTC 2019
Zika Virus Infection Induces DNA Damage Response in Human Neural Progenitors That Enhances Viral Replication.
Journal of virology
Hammack C,Ogden SC,Madden JC,Medina A,Xu C,Phillips E,Son Y,Cone A,Giovinazzi S,Didier RA,Gilbert DM,Song H,Ming G,Wen Z,Brinton MA,Gunjan A,Tang H
MA1-2022 was used in Immunocytochemistry to show that ZIKV manipulates the cell cycle to benefit viral replication.
Tue Oct 15 00:00:00 UTC 2019
Conservative site-specific and single-copy transgenesis in human LINE-1 elements.
Nucleic acids research
Vijaya Chandra SH,Makhija H,Peter S,Myint Wai CM,Li J,Zhu J,Ren Z,D'Alcontres MS,Siau JW,Chee S,Ghadessy FJ,Dröge P
MA1-2022 was used in western blot to discuss Phage lambda integrase as a transgenesis tool
Thu Apr 07 00:00:00 UTC 2016
Conservative site-specific and single-copy transgenesis in human LINE-1 elements.
Nucleic acids research
Vijaya Chandra SH,Makhija H,Peter S,Myint Wai CM,Li J,Zhu J,Ren Z,D'Alcontres MS,Siau JW,Chee S,Ghadessy FJ,Dröge P
MA1-2022 was used in western blot to discuss Phage lambda integrase as a transgenesis tool
Thu Apr 07 00:00:00 UTC 2016
ATM/G6PD-driven redox metabolism promotes FLT3 inhibitor resistance in acute myeloid leukemia.
Proceedings of the National Academy of Sciences of the United States of America
Gregory MA,D'Alessandro A,Alvarez-Calderon F,Kim J,Nemkov T,Adane B,Rozhok AI,Kumar A,Kumar V,Pollyea DA,Wempe MF,Jordan CT,Serkova NJ,Tan AC,Hansen KC,DeGregori J
MA12022 was used in western blot to show that inactivating ATM or G6PD sensitizes acute myeloid leukemia cells to FLT3 inhibitor-induced apoptosis
Tue Oct 25 00:00:00 UTC 2016
ATM/G6PD-driven redox metabolism promotes FLT3 inhibitor resistance in acute myeloid leukemia.
Proceedings of the National Academy of Sciences of the United States of America
Gregory MA,D'Alessandro A,Alvarez-Calderon F,Kim J,Nemkov T,Adane B,Rozhok AI,Kumar A,Kumar V,Pollyea DA,Wempe MF,Jordan CT,Serkova NJ,Tan AC,Hansen KC,DeGregori J
MA12022 was used in western blot to show that inactivating ATM or G6PD sensitizes acute myeloid leukemia cells to FLT3 inhibitor-induced apoptosis
Tue Oct 25 00:00:00 UTC 2016
Elevated Expression of Hepatoma Up-Regulated Protein Inhibits γ-Irradiation-Induced Apoptosis of Prostate Cancer Cells.
Journal of cellular biochemistry
Hassan M,El Khattouti A,Ejaeidi A,Ma T,Day WA,Espinoza I,Vijayakumar S,Gomez CR
MA1-2022 was used in immunocytochemistry and western blot to characterize inhibition of gamma-irradiation-induced apoptosis of prostate cancer cells by elevated expression of hepatoma up-regulated protein
Wed Jun 01 00:00:00 UTC 2016
Elevated Expression of Hepatoma Up-Regulated Protein Inhibits γ-Irradiation-Induced Apoptosis of Prostate Cancer Cells.
Journal of cellular biochemistry
Hassan M,El Khattouti A,Ejaeidi A,Ma T,Day WA,Espinoza I,Vijayakumar S,Gomez CR
MA1-2022 was used in immunocytochemistry and western blot to characterize inhibition of gamma-irradiation-induced apoptosis of prostate cancer cells by elevated expression of hepatoma up-regulated protein
Wed Jun 01 00:00:00 UTC 2016
High Content Screening Analysis to Evaluate the Toxicological Effects of Harmful and Potentially Harmful Constituents (HPHC).
Journal of visualized experiments : JoVE
Marescotti D,Gonzalez Suarez I,Acali S,Johne S,Laurent A,Frentzel S,Hoeng J,Peitsch MC
MA1-2022 was used in immunocytochemistry to evaluate the toxicological effects of harmful and potentially harmful constituents (HPHC) by utilizing a high content screening analysis
Tue May 10 00:00:00 UTC 2016
A high-throughput chemical screen reveals that harmine-mediated inhibition of DYRK1A increases human pancreatic beta cell replication.
Nature medicine
Wang P,Alvarez-Perez JC,Felsenfeld DP,Liu H,Sivendran S,Bender A,Kumar A,Sanchez R,Scott DK,Garcia-Ocaña A,Stewart AF
MA1-2022 was used in immunocytochemistry to identify analogs of harmine as a new class of human beta cell mitogenic compounds and identify the pathways they activate.
Wed Apr 01 00:00:00 UTC 2015
Organization and dynamics of the nonhomologous end-joining machinery during DNA double-strand break repair.
Proceedings of the National Academy of Sciences of the United States of America
Reid DA,Keegan S,Leo-Macias A,Watanabe G,Strande NT,Chang HH,Oksuz BA,Fenyo D,Lieber MR,Ramsden DA,Rothenberg E
MA1-2022 was used in Immunofluorescence to study the nonhomolgous end-joining repair proteins present at DNA double-stranded breaks using in vivo and in vitro single-molecule methods.
Tue May 19 00:00:00 UTC 2015
Profiling dose-dependent activation of p53-mediated signaling pathways by chemicals with distinct mechanisms of DNA damage.
Toxicological sciences : an official journal of the Society of Toxicology
Clewell RA,Sun B,Adeleye Y,Carmichael P,Efremenko A,McMullen PD,Pendse S,Trask OJ,White A,Andersen ME
MA1-2022 was used in western blot to develop high throughput methods to assess proof-of-concept in vitro-only risk assessments
Sat Nov 01 00:00:00 UTC 2014
Comparative analysis of the cytotoxic effects of okadaic acid-group toxins on human intestinal cell lines.
Marine drugs
Ferron PJ,Hogeveen K,Fessard V,Le Hégarat L
MA1-2022 was used in immunocytochemistry to compared the toxicological effects of okadaic acid and dinophysistoxin 1 and 2
Thu Aug 21 00:00:00 UTC 2014
Comparative analysis of the cytotoxic effects of okadaic acid-group toxins on human intestinal cell lines.
Marine drugs
Ferron PJ,Hogeveen K,Fessard V,Le Hégarat L
MA1-2022 was used in immunocytochemistry to compared the toxicological effects of okadaic acid and dinophysistoxin 1 and 2
Thu Aug 21 00:00:00 UTC 2014
Cytotoxicity, fractionation and dereplication of extracts of the dinoflagellate Vulcanodinium rugosum, a producer of pinnatoxin G.
Marine drugs
Geiger M,Desanglois G,Hogeveen K,Fessard V,Leprêtre T,Mondeguer F,Guitton Y,Hervé F,Séchet V,Grovel O,Pouchus YF,Hess P
MA1-2022 was used in immunocytochemistry to isolate and identify N-carboxy-methyl-smenospongine as the likely cytotoxic and genotoxic component of extracts of Vulcanodium rugosum
Mon Sep 02 00:00:00 UTC 2013
Cytotoxicity, fractionation and dereplication of extracts of the dinoflagellate Vulcanodinium rugosum, a producer of pinnatoxin G.
Marine drugs
Geiger M,Desanglois G,Hogeveen K,Fessard V,Leprêtre T,Mondeguer F,Guitton Y,Hervé F,Séchet V,Grovel O,Pouchus YF,Hess P
MA1-2022 was used in immunocytochemistry to isolate and identify N-carboxy-methyl-smenospongine as the likely cytotoxic and genotoxic component of extracts of Vulcanodium rugosum
Mon Sep 02 00:00:00 UTC 2013
The NR4A2 nuclear receptor is recruited to novel nuclear foci in response to UV irradiation and participates in nucleotide excision repair.
PloS one
Jagirdar K,Yin K,Harrison M,Lim W,Muscat GE,Sturm RA,Smith AG
MA1-2022 was used in immunocytochemistry to study the mechanism underlying the role of the NR4A2 nuclear receptor in nucleotide excision repair in response to damage caused by UV irradiation
Wed Aug 20 00:00:00 UTC 2014
Development of a two-step chromatography procedure that allows the purification of a high-purity anti-histone H1 monoclonal immunoglobulin M antibody with immunosuppressant activity.
Biomedical chromatography : BMC
Shimada Y,Goto T,Kawamoto S,Kiso T,Katayama A,Yamanaka Y,Aki T,Chiang KC,Nakano T,Goto S,Chen CL,Ohmori N,Ono K,Sato S
MA1-2022 was used in ELISA to generate and evaluate a monoclonal antibody with immunosuppressant activity
Tue Jan 01 00:00:00 UTC 2008
