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Phospho-IRAK-M (Ser510) Antibody (PA5-105121) in WB
Western blot analysis of Phospho-IRAK-M (Ser510) in 293T cell lysate (Lane 1: treated with phospho-blocking peptide; Lane 2: treated with non-phospho-blocking peptide). Samples were incubated with Phospho-IRAK-M (Ser510) polyclonal antibody (Product # PA5-105121).
Product Details
PA5-105121
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human IRAK3(Accession Q9Y616), corresponding to amino acid residues around phosphorylated Ser510.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
sequential chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2816594
Product Specific Information
Antibody detects endogenous levels of IRAK3 only when phosphorylated at Ser510.
Target Information
IRAK3 serine/threonine kinase or interleukin-1 receptor-associated kinase 3 is a member of the interleukin-1 receptor-associated kinase protein family which are essential components of the Toll/IL-R immune signal transduction pathways. IRAK3 is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. IRAK3 mediates critical aspects of innate immunity that result in an immunocompromised state during sepsis. Mutations in IRAK3 are associated with a susceptibility to asthma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ13601; IL-1 receptor-associated kinase M; Inactive IL-1 receptor-associated kinase 3; Interleukin-1 receptor-associated kinase 3; IRAK-3; IRAK-M; IRAK3
Gene Aliases: 4833428C18Rik; AI563835; ASRT5; IRAK-M; IRAK3; IRAKM
UniProt ID: (Human) Q9Y616, (Mouse) Q8K4B2
Entrez Gene ID: (Human) 11213, (Mouse) 73914, (Rat) 314870
magnesium ion binding
protein serine/threonine kinase activity
ATP binding
protein homodimerization activity
protein heterodimerization activity
nucleotide binding
protein kinase activity
protein binding
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
molecular_function
negative regulation of cytokine-mediated signaling pathway
MyD88-dependent toll-like receptor signaling pathway
protein phosphorylation
response to virus
positive regulation of macrophage tolerance induction
negative regulation of macrophage cytokine production
cytokine-mediated signaling pathway
negative regulation of NF-kappaB transcription factor activity
response to peptidoglycan
response to lipopolysaccharide
negative regulation of interleukin-12 production
negative regulation of interleukin-6 production
negative regulation of tumor necrosis factor production
negative regulation of toll-like receptor signaling pathway
negative regulation of protein catabolic process
negative regulation of protein complex disassembly
regulation of protein complex disassembly
response to exogenous dsRNA
negative regulation of MAP kinase activity
negative regulation of innate immune response
protein autophosphorylation
positive regulation of NF-kappaB transcription factor activity
interleukin-1-mediated signaling pathway
response to interleukin-1
toll-like receptor signaling pathway
apoptotic process
signal transduction
phosphorylation
intracellular signal transduction
regulation of apoptotic process
biological_process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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