Invitrogen

Phospho-IRF7 (Ser477) Polyclonal Antibody

View all (19) IRF7 antibodies

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-106184

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:3,000
-

Immunohistochemistry (IHC)

1:50-1:200
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human IRF7(Accession Q92985), corresponding to amino acid residues around phosphorylated Ser477.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

sequential chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2817582

Product Specific Information

Antibody detects endogenous levels of IRF7 only when phosphorylated at Ser477.

Target Information

Interferons (IFNs) are involved in a multitude of immune interactions during viral infections and play a major role in both the induction and regulation of innate and adaptive antiviral mechanisms. During infection, host-virus interactions signal downstream molecules such as transcription factors such as IFN regulatory factor-3 (IRF3) which can act to stimulate transcription of IFN-a/b genes. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. IRF7 play a major role in the innate immune pathway, interacting with the Toll-like receptor (TLR) adaptor proteins MyD88 and Tirp/TRAM and functioning as an intermediate TLR4 and TLR9 signaling. There are at least four differentially spliced isoforms of IRF7, although their function has not been clearly established.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Interferon regulatory factor 7; interferon regulatory factor-7H; IRF-7

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Gene Aliases: IMD39; IRF-7H; IRF7; IRF7A; IRF7B; IRF7C; IRF7H

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UniProt ID: (Human) Q92985, (Mouse) P70434

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Entrez Gene ID: (Human) 3665, (Mouse) 54123, (Rat) 293624

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Function(s)
RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding DNA binding protein binding regulatory region DNA binding transcription factor activity, sequence-specific DNA binding
Process(es)
immune system process regulation of adaptive immune response transcription, DNA-templated regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter immunoglobulin mediated immune response positive regulation of type I interferon production interferon-alpha production interferon-beta production positive regulation of interferon-alpha production positive regulation of interferon-beta production regulation of MyD88-dependent toll-like receptor signaling pathway regulation of MyD88-independent toll-like receptor signaling pathway innate immune response regulation of innate immune response type I interferon biosynthetic process positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter positive regulation of type I interferon-mediated signaling pathway negative regulation of transcription from RNA polymerase II promoter cellular response to DNA damage stimulus response to virus establishment of viral latency regulation of type I interferon production TRIF-dependent toll-like receptor signaling pathway MDA-5 signaling pathway regulation of monocyte differentiation regulation of immune response interferon-gamma-mediated signaling pathway type I interferon signaling pathway negative regulation of macrophage apoptotic process
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