Product References
PICK1-Deficient Mice Maintain Their Glucose Tolerance During Diet-Induced Obesity.
Journal of the Endocrine Society
Backe MB,Andersen RC,Jensen M,Jin C,Hundahl C,Dmytriyeva O,Treebak JT,Hansen JB,Gerhart-Hines Z,Madsen KL,Holst B
Published figure using Phospho-IRS1 (Tyr612) polyclonal antibody (Product # 44-816G) in Western Blot
Fri May 05 00:00:00 UTC 2023
Ginsenoside compound K reduces ischemia/reperfusion-induced neuronal apoptosis by inhibiting PTP1B-mediated IRS1 tyrosine dephosphorylation.
Journal of ginseng research
Fu J,Yu L,Yu Q,Yu N,Xu F,Li S
44-816G was used in Immunohistochemistry (Paraffin) to explore the docking protein of ginsenoside CK mediating the neuroprotective effects.
Wed Mar 01 00:00:00 UTC 2023
A Phase 0 Trial of Ceritinib in Patients with Brain Metastases and Recurrent Glioblastoma.
Clinical cancer research : an official journal of the American Association for Cancer Research
Mehta S,Fiorelli R,Bao X,Pennington-Krygier C,Derogatis A,Kim S,Yoo W,Li J,Sanai N
44-816G was used in Immunohistochemistry to conclude that ceritinib is highly bound to plasma proteins and tumor tissues. Unbound drug concentrations achieved in brain metastases and patients with recurrent glioblastoma were insufficient for target modulation.
Sat Jan 15 00:00:00 UTC 2022
A Phase 0 Trial of Ceritinib in Patients with Brain Metastases and Recurrent Glioblastoma.
Clinical cancer research : an official journal of the American Association for Cancer Research
Mehta S,Fiorelli R,Bao X,Pennington-Krygier C,Derogatis A,Kim S,Yoo W,Li J,Sanai N
44-816G was used in Immunohistochemistry to conclude that ceritinib is highly bound to plasma proteins and tumor tissues. Unbound drug concentrations achieved in brain metastases and patients with recurrent glioblastoma were insufficient for target modulation.
Sat Jan 15 00:00:00 UTC 2022
Repurposing Ceritinib Induces DNA Damage and Enhances PARP Inhibitor Responses in High-Grade Serous Ovarian Carcinoma.
Cancer research
Kanakkanthara A,Hou X,Ekstrom TL,Zanfagnin V,Huehls AM,Kelly RL,Ding H,Larson MC,Vasmatzis G,Oberg AL,Kaufmann SH,Mansfield AS,Weroha SJ,Karnitz LM
44-816G was used in Western Blot to conclude that the kinase inhibitor ceritinib synergizes with PARPi to induce tumor regression in ovarian cancer models, suggesting that ceritinib combined with PARPi may be an effective strategy for treating ovarian cancer.
Sat Jan 15 00:00:00 UTC 2022
Cullin neddylation inhibitor attenuates hyperglycemia by enhancing hepatic insulin signaling through insulin receptor substrate stabilization.
Proceedings of the National Academy of Sciences of the United States of America
Chen C,Gu L,Matye DJ,Clayton YD,Hasan MN,Wang Y,Friedman JE,Li T
44-816G was used in Immuno-assay to suggest that pharmacological inhibition of cullin neddylation represents a therapeutic approach for improving hepatic insulin signaling and lowering blood glucose.
Tue Feb 08 00:00:00 UTC 2022
Time-restricted feeding combined with aerobic exercise training can prevent weight gain and improve metabolic disorders in mice fed a high-fat diet.
The Journal of physiology
Vieira RFL,Muñoz VR,Junqueira RL,de Oliveira F,Gaspar RC,Nakandakari SCBR,Costa SO,Torsoni MA,da Silva ASR,Cintra DE,de Moura LP,Ropelle ER,Zaghloul I,Mekary RA,Pauli JR
44-816G was used in Immunohistochemistry (Paraffin), Western Blot to show that TRF alone has benefits but TRF+Exe has additive benefits and can mitigate the harmful effects of consuming a high-fat diet on body adiposity, liver metabolism and glycaemic homeostasis in young male Swiss mice.
Tue Feb 01 00:00:00 UTC 2022
The CX3CL1 intracellular domain exhibits neuroprotection via insulin receptor/insulin-like growth factor receptor signaling.
The Journal of biological chemistry
Gayen M,Benoit MR,Fan Q,Hudobenko J,Yan R
44-816G was used in Immunohistochemistry (Paraffin), Western Blot to suggest that CX3CL1-ICD may have translational potential for neuroprotection in Alzheimer's disease and for disorders resulting from insulin resistance.
Tue Nov 01 00:00:00 UTC 2022
Monascus-fermented grain vinegar enhances glucose homeostasis through the IRS-1/PI3K/Akt and AMPK signaling pathways in HepG2 cell and db/db mice.
Food science and biotechnology
Lee YW,Pyo YH
44-816G was used in Western Blot to show that MV regulates both signaling pathways and improves the glucose metabolism disorder.
Tue Nov 01 00:00:00 UTC 2022
JMJD8 is a Novel Molecular Nexus Between Adipocyte-Intrinsic Inflammation and Insulin Resistance.
Diabetes
You D,Chul Jung B,Villivalam SD,Lim HW,Kang S
44-816G was used in Functional Assay to study Jumonji C Domain Containing Protein 8 (JMJD8) as a driver of adipocyte inflammation in conjunction with insulin sensitivity.
Thu Oct 21 00:00:00 UTC 2021
The role of Smad4 in the regulation of insulin resistance, inflammation and cell proliferation in HTR8-Svneo cells.
Cell biochemistry and function
Li L,Bai Y,Du R,Tang L,Li L
44-816G was used in Immunohistochemistry (Paraffin), Western Blot to report that deficiency of Smad4 significantly improves insulin sensitivity, relieving inflamation in IR cellular model; and has a positive effect on cell viability.
Fri Jan 01 00:00:00 UTC 2021
The E3 ligase TRAF4 promotes IGF signaling by mediating atypical ubiquitination of IRS-1.
The Journal of biological chemistry
Yu W,Singh R,Wang Z,O'Malley BW,Yi P
44-816G was used in Immunoprecipitation to demonstrate that TRAF4-mediated ubiquitination of IRS-1 is essential for insulin-like growth factor signal transduction.
Tue Aug 31 00:00:00 UTC 2021
The E3 ligase TRAF4 promotes IGF signaling by mediating atypical ubiquitination of IRS-1.
The Journal of biological chemistry
Yu W,Singh R,Wang Z,O'Malley BW,Yi P
44-816G was used in Immunoprecipitation to demonstrate that TRAF4-mediated ubiquitination of IRS-1 is essential for insulin-like growth factor signal transduction.
Tue Aug 31 00:00:00 UTC 2021
Insulin Resistance and Pellino-1 Mediated Decrease in the Activities of Vasodilator Signaling Contributes to Sunitinib-Induced Hypertension.
Frontiers in pharmacology
Liu Y,Tang LL,Liang C,Wu MM,Zhang ZR
Published figure using Phospho-IRS1 (Tyr612) polyclonal antibody (Product # 44-816G) in Western Blot
Tue Apr 13 00:00:00 UTC 2021
Exercise Counterbalances Rho/ROCK2 Signaling Impairment in the Skeletal Muscle and Ameliorates Insulin Sensitivity in Obese Mice.
Frontiers in immunology
Muñoz VR,Gaspar RC,Severino MB,Macêdo APA,Simabuco FM,Ropelle ER,Cintra DE,da Silva ASR,Kim YB,Pauli JR
44-816G was used in Western Blot to understand the molecular mechanisms underlying the effect of physical exercise in improving insulin sensitivity and glucose uptake in skeletal muscle.
Tue Dec 21 00:00:00 UTC 2021
Exercise Counterbalances Rho/ROCK2 Signaling Impairment in the Skeletal Muscle and Ameliorates Insulin Sensitivity in Obese Mice.
Frontiers in immunology
Muñoz VR,Gaspar RC,Severino MB,Macêdo APA,Simabuco FM,Ropelle ER,Cintra DE,da Silva ASR,Kim YB,Pauli JR
44-816G was used in Western Blot to understand the molecular mechanisms underlying the effect of physical exercise in improving insulin sensitivity and glucose uptake in skeletal muscle.
Tue Dec 21 00:00:00 UTC 2021
The anti-diabetic effects of NAG-1/GDF15 on HFD/STZ-induced mice.
Scientific reports
Lertpatipanpong P,Lee J,Kim I,Eling T,Oh SY,Seong JK,Baek SJ
44-816G was used in Western Blot to suggest that NAG-1 expression alleviates diabetes in mice.
Thu Jul 22 00:00:00 UTC 2021
The anti-diabetic effects of NAG-1/GDF15 on HFD/STZ-induced mice.
Scientific reports
Lertpatipanpong P,Lee J,Kim I,Eling T,Oh SY,Seong JK,Baek SJ
44-816G was used in Western Blot to suggest that NAG-1 expression alleviates diabetes in mice.
Thu Jul 22 00:00:00 UTC 2021
Role of Exendin-4 in Brain Insulin Resistance, Mitochondrial Function, and Neurite Outgrowth in Neurons under Palmitic Acid-Induced Oxidative Stress.
Antioxidants (Basel, Switzerland)
Jo D,Yoon G,Song J
44-816G was used in Western Blot, Immunocytochemistry to investigate whether or not Exentin-4 (Ex-4; GLP-1 agonist) inhibits higher production of reactive oxygen species (ROS) in an SH-SY5Y neuronal cell line under PA-induced apoptosis conditions.
Sat Jan 09 00:00:00 UTC 2021
Role of Exendin-4 in Brain Insulin Resistance, Mitochondrial Function, and Neurite Outgrowth in Neurons under Palmitic Acid-Induced Oxidative Stress.
Antioxidants (Basel, Switzerland)
Jo D,Yoon G,Song J
44-816G was used in Western Blot, Immunocytochemistry to investigate whether or not Exentin-4 (Ex-4; GLP-1 agonist) inhibits higher production of reactive oxygen species (ROS) in an SH-SY5Y neuronal cell line under PA-induced apoptosis conditions.
Sat Jan 09 00:00:00 UTC 2021
Role of Exendin-4 in Brain Insulin Resistance, Mitochondrial Function, and Neurite Outgrowth in Neurons under Palmitic Acid-Induced Oxidative Stress.
Antioxidants (Basel, Switzerland)
Jo D,Yoon G,Song J
44-816G was used in Western Blot, Immunocytochemistry to investigate whether or not Exentin-4 (Ex-4; GLP-1 agonist) inhibits higher production of reactive oxygen species (ROS) in an SH-SY5Y neuronal cell line under PA-induced apoptosis conditions.
Sat Jan 09 00:00:00 UTC 2021
Role of Exendin-4 in Brain Insulin Resistance, Mitochondrial Function, and Neurite Outgrowth in Neurons under Palmitic Acid-Induced Oxidative Stress.
Antioxidants (Basel, Switzerland)
Jo D,Yoon G,Song J
44-816G was used in Western Blot, Immunocytochemistry to investigate whether or not Exentin-4 (Ex-4; GLP-1 agonist) inhibits higher production of reactive oxygen species (ROS) in an SH-SY5Y neuronal cell line under PA-induced apoptosis conditions.
Sat Jan 09 00:00:00 UTC 2021
The autophagy protein Becn1 improves insulin sensitivity by promoting adiponectin secretion via exocyst binding.
Cell reports
Kuramoto K,Kim YJ,Hong JH,He C
44-816G was used in Western Blot to demonstrate that Becn1 improves insulin sensitivity by facilitating adiponectin secretion through binding the exocyst in adipose tissue.
Tue May 25 00:00:00 UTC 2021
Short-term administration of C. aronia stimulates insulin signaling, suppresses fatty acids metabolism, and increases glucose uptake and utilization in the hearts of healthy rats.
Saudi journal of biological sciences
Shatoor AS,Al Humayed S,Almohiy HM
44-816G was used in Immunohistochemistry (Paraffin), Western Blot to evaluate the effect of Crataegus aronia aqueous extract on cardiac substrate utilization and insulin signalling.
Mon Mar 01 00:00:00 UTC 2021
Altered Insulin Receptor Substrate 1 Phosphorylation in Blood Neuron-Derived Extracellular Vesicles From Patients With Parkinson's Disease.
Frontiers in cell and developmental biology
Chou SY,Chan L,Chung CC,Chiu JY,Hsieh YC,Hong CT
44-816G was used in Immunoprecipitation to suggest the association between dysinsulin signaling pathway with PD.
Sat Nov 04 00:00:00 UTC 2023
IPF pathogenesis is dependent upon TGFβ induction of IGF-1.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Hernandez DM,Kang JH,Choudhury M,Andrianifahanana M,Yin X,Limper AH,Leof EB
44-816G was used in Western Blotting to expand knowledge of IGF-1's role as a novel fibrotic-switch, bringing us one step closer to understanding the complex biological mechanisms responsible for fibrotic diseases and developing effective therapies.
Wed Apr 01 00:00:00 UTC 2020
Intranasal insulin administration may be highly effective in improving cognitive function in mice with cognitive dysfunction by reversing brain insulin resistance.
Cognitive neurodynamics
Lv H,Tang L,Guo C,Jiang Y,Gao C,Wang Y,Jian C
44-816G was used in Western Blot to establish a brain insulin resistance model through an intraventricular injection of streptozotocin, accompanied by cognitive impairment.
Mon Jun 01 00:00:00 UTC 2020
Direct Effects of D-Chiro-Inositol on Insulin Signaling and Glucagon Secretion of Pancreatic Alpha Cells.
Biomolecules
Filippello A,Scamporrino A,Di Mauro S,Malaguarnera R,Di Pino A,Scicali R,Purrello F,Piro S
44-816G was used in Western Blotting to investigate the preventive role of D-chiro-inositol (DCI).
Sun Oct 04 00:00:00 UTC 2020
Direct Effects of D-Chiro-Inositol on Insulin Signaling and Glucagon Secretion of Pancreatic Alpha Cells.
Biomolecules
Filippello A,Scamporrino A,Di Mauro S,Malaguarnera R,Di Pino A,Scicali R,Purrello F,Piro S
44-816G was used in Western Blotting to investigate the preventive role of D-chiro-inositol (DCI).
Sun Oct 04 00:00:00 UTC 2020
Iron overload inhibits late stage autophagic flux leading to insulin resistance.
EMBO reports
Jahng JWS,Alsaadi RM,Palanivel R,Song E,Hipolito VEB,Sung HK,Botelho RJ,Russell RC,Sweeney G
44-816G was used in Western Blot to show that chronic iron overload leads to a profound autophagy defect through mTORC1-UVRAG inhibition and provides new mechanistic insight into metabolic syndrome-associated insulin resistance.
Fri Oct 04 00:00:00 UTC 2019
Iron overload inhibits late stage autophagic flux leading to insulin resistance.
EMBO reports
Jahng JWS,Alsaadi RM,Palanivel R,Song E,Hipolito VEB,Sung HK,Botelho RJ,Russell RC,Sweeney G
44-816G was used in Western Blot to show that chronic iron overload leads to a profound autophagy defect through mTORC1-UVRAG inhibition and provides new mechanistic insight into metabolic syndrome-associated insulin resistance.
Fri Oct 04 00:00:00 UTC 2019
The Diurnal Rhythm of Insulin Receptor Substrate-1 (IRS-1) and Kir4.1 in Diabetes: Implications for a Clock Gene Bmal1.
Investigative ophthalmology & visual science
Luo Q,Xiao Y,Alex A,Cummins TR,Bhatwadekar AD
44-816G was used in Western Blotting to hypothesize that diabetes will result in a circadian dysrhythmia of IRS-1 and Kir4.1 and disturbed clock gene function will have a critical role in regulating Kir4.1 channels.
Wed May 01 00:00:00 UTC 2019
The Diurnal Rhythm of Insulin Receptor Substrate-1 (IRS-1) and Kir4.1 in Diabetes: Implications for a Clock Gene Bmal1.
Investigative ophthalmology & visual science
Luo Q,Xiao Y,Alex A,Cummins TR,Bhatwadekar AD
44-816G was used in Western Blotting to hypothesize that diabetes will result in a circadian dysrhythmia of IRS-1 and Kir4.1 and disturbed clock gene function will have a critical role in regulating Kir4.1 channels.
Wed May 01 00:00:00 UTC 2019
Coenzyme Q10 protects against burn-induced mitochondrial dysfunction and impaired insulin signaling in mouse skeletal muscle.
FEBS open bio
Nakazawa H,Ikeda K,Shinozaki S,Yasuhara S,Yu YM,Martyn JAJ,Tompkins RG,Yorozu T,Inoue S,Kaneki M
44-816G was used in Western Blotting to study the protective effects of coenzyme Q10 against burn-induced mitochondrial dysfunction and impaired insulin signalling in mouse skeletal muscle.
Fri Feb 01 00:00:00 UTC 2019
TET2 facilitates PPARγ agonist-mediated gene regulation and insulin sensitization in adipocytes.
Metabolism: clinical and experimental
Bian F,Ma X,Villivalam SD,You D,Choy LR,Paladugu A,Fung S,Kang S
44-816G was used in Immunoprecipitation to study whether DNA demethylase ten-eleven translocation proteins regulate the metabolic functions of adipocytes.
Sat Dec 01 00:00:00 UTC 2018
Molecular and Structural Traits of Insulin Receptor Substrate 1/LC3 Nuclear Structures and Their Role in Autophagy Control and Tumor Cell Survival.
Molecular and cellular biology
Lassak A,Dean M,Wyczechowska D,Wilk A,Marrero L,Trillo-Tinoco J,Boulares AH,Sarkaria JN,Del Valle L,Peruzzi F,Ochoa A,Reiss K
44-816G was used in Immunohistochemistry-immunofluorescence to identify a unique insulin receptor substrate 1 nuclear structure, in glioblastoma biopsies and glioblastoma xenografts.
Tue May 15 00:00:00 UTC 2018
Molecular and Structural Traits of Insulin Receptor Substrate 1/LC3 Nuclear Structures and Their Role in Autophagy Control and Tumor Cell Survival.
Molecular and cellular biology
Lassak A,Dean M,Wyczechowska D,Wilk A,Marrero L,Trillo-Tinoco J,Boulares AH,Sarkaria JN,Del Valle L,Peruzzi F,Ochoa A,Reiss K
44-816G was used in Immunohistochemistry-immunofluorescence to identify a unique insulin receptor substrate 1 nuclear structure, in glioblastoma biopsies and glioblastoma xenografts.
Tue May 15 00:00:00 UTC 2018
Ablation of Grb10 Specifically in Muscle Impacts Muscle Size and Glucose Metabolism in Mice.
Endocrinology
Holt LJ,Brandon AE,Small L,Suryana E,Preston E,Wilks D,Mokbel N,Coles CA,White JD,Turner N,Daly RJ,Cooney GJ
44-816G was used in Western Blotting to conclude that ablation of Grb10 in muscle is sufficient to affect muscle size and metabolism, supporting an important role for this protein in growth and metabolic pathways.
Thu Mar 01 00:00:00 UTC 2018
Chronic restraint stress induces hippocampal memory deficits by impairing insulin signaling.
Molecular brain
Woo H,Hong CJ,Jung S,Choe S,Yu SW
44-816G was used in Western Blotting to suggest that psychological stress impairs insulin signalling and results in hippocampal deficits.
Tue Jul 03 00:00:00 UTC 2018
Exercise increases Rho-kinase activity and insulin signaling in skeletal muscle.
Journal of cellular physiology
Muñoz VR,Gaspar RC,Kuga GK,da Rocha AL,Crisol BM,Botezelli JD,Baptista IL,Mekary RA,da Silva ASR,Cintra DE,de Moura LP,Ropelle ER,Pauli JR
44-816G was used in Immunohistochemistry (Paraffin), Western Blot to conclude that the short-term exercise increased both insulin sensitivity and glucose tolerance, through the increased Rock activity and pIRS1 (serine 632/635) mediated by Rock, in the skeletal muscle of Fischer 344 rats.
Fri Jun 01 00:00:00 UTC 2018
Tau deletion promotes brain insulin resistance.
The Journal of experimental medicine
Marciniak E,Leboucher A,Caron E,Ahmed T,Tailleux A,Dumont J,Issad T,Gerhardt E,Pagesy P,Vileno M,Bournonville C,Hamdane M,Bantubungi K,Lancel S,Demeyer D,Eddarkaoui S,Vallez E,Vieau D,Humez S,Faivre E,Grenier-Boley B,Outeiro TF,Staels B,Amouyel P,Balschun D,Buee L,Blum D
44-816G was used in Western Blotting to find that tau deletion leads to an impaired hippocampal response to insulin, caused by altered IRS-1 and PTEN activity.
Mon Aug 07 00:00:00 UTC 2017
Dnmt3a is an epigenetic mediator of adipose insulin resistance.
eLife
You D,Nilsson E,Tenen DE,Lyubetskaya A,Lo JC,Jiang R,Deng J,Dawes BA,Vaag A,Ling C,Rosen ED,Kang S
44-816G was used in Western Blotting to demonstrate that adipose Dnmt3a is a novel epigenetic mediator of insulin resistance in vitro and in vivo.
Wed Nov 01 00:00:00 UTC 2017
Regulating the effects of GPR21, a novel target for type 2 diabetes.
Scientific reports
Leonard S,Kinsella GK,Benetti E,Findlay JBC
44-816G was used in western blot to utilize a novel targe for type 2 diabetes and regulate the effects of GPR21
Tue May 31 00:00:00 UTC 2016
Epigenetic regulation of macrophage polarization and inflammation by DNA methylation in obesity.
JCI insight
Wang X,Cao Q,Yu L,Shi H,Xue B,Shi H
44816G was used in western blot to show that DNA hypermethylation at the PPARgamma1 promoter is induced by obesity-related factors
Thu Nov 17 00:00:00 UTC 2016
Fetuin B Is a Secreted Hepatocyte Factor Linking Steatosis to Impaired Glucose Metabolism.
Cell metabolism
Meex RC,Hoy AJ,Morris A,Brown RD,Lo JC,Burke M,Goode RJ,Kingwell BA,Kraakman MJ,Febbraio MA,Greve JW,Rensen SS,Molloy MP,Lancaster GI,Bruce CR,Watt MJ
44-816G was used in Western Blotting to determine whether protein signals originating from steatotic hepatocytes communicate with other cells to modulate metabolic phenotypes.
Tue Dec 01 00:00:00 UTC 2015
Basal expression of insulin-like growth factor 1 receptor determines intrinsic resistance of cancer cells to a phosphatidylinositol 3-kinase inhibitor ZSTK474.
Cancer science
Isoyama S,Kajiwara G,Tamaki N,Okamura M,Yoshimi H,Nakamura N,Kawamura K,Nishimura Y,Namatame N,Yamori T,Dan S
44-816G was used in western blot to examine the relationship of IGF1R and PI3Kis in chemotherapy resistance of cancer.
Sun Feb 01 00:00:00 UTC 2015
Type 1 Insulin-Like Growth Factor Receptor/Insulin Receptor Substrate 1 Signaling Confers Pathogenic Activity on Breast Tumor Cells Lacking REST.
Molecular and cellular biology
Meyer K,Albaugh B,Schoenike B,Roopra A
44-816G was used in western blot to investigate how loss of RE-1 Silencing Transcription Factor affects breast cancer.
Tue Sep 01 00:00:00 UTC 2015
Type 1 Insulin-Like Growth Factor Receptor/Insulin Receptor Substrate 1 Signaling Confers Pathogenic Activity on Breast Tumor Cells Lacking REST.
Molecular and cellular biology
Meyer K,Albaugh B,Schoenike B,Roopra A
44-816G was used in western blot to investigate how loss of RE-1 Silencing Transcription Factor affects breast cancer.
Tue Sep 01 00:00:00 UTC 2015
Severe insulin resistance alters metabolism in mesenchymal progenitor cells.
Endocrinology
Balhara B,Burkart A,Topcu V,Lee YK,Cowan C,Kahn CR,Patti ME
44-816G was used in immunocytochemistry and western blot to study Donohue syndrome in mesenchymal progenitor cells derived from human patients.
Mon Jun 01 00:00:00 UTC 2015
Insulin and IGF1 signalling pathways in human astrocytes in vitro and in vivo; characterisation, subcellular localisation and modulation of the receptors.
Molecular brain
Garwood CJ,Ratcliffe LE,Morgan SV,Simpson JE,Owens H,Vazquez-Villaseñor I,Heath PR,Romero IA,Ince PG,Wharton SB
44-816G was used in western blot to study the insulin/IGF1 signaling pathway in human astrocytes.
Sat Aug 22 00:00:00 UTC 2015
Insulin and IGF1 signalling pathways in human astrocytes in vitro and in vivo; characterisation, subcellular localisation and modulation of the receptors.
Molecular brain
Garwood CJ,Ratcliffe LE,Morgan SV,Simpson JE,Owens H,Vazquez-Villaseñor I,Heath PR,Romero IA,Ince PG,Wharton SB
44-816G was used in western blot to study the insulin/IGF1 signaling pathway in human astrocytes.
Sat Aug 22 00:00:00 UTC 2015
Role of protein farnesylation in burn-induced metabolic derangements and insulin resistance in mouse skeletal muscle.
PloS one
Nakazawa H,Yamada M,Tanaka T,Kramer J,Yu YM,Fischman AJ,Martyn JA,Tompkins RG,Kaneki M
44-816G was used in western blot to elucidate the role of farnesylation in burn-induced metabolic aberration
Thu Oct 08 00:00:00 UTC 2015
PTEN is a protein tyrosine phosphatase for IRS1.
Nature structural & molecular biology
Shi Y,Wang J,Chandarlapaty S,Cross J,Thompson C,Rosen N,Jiang X
44-816G was used in Western Blotting to study whether mammalian PTEN selectively dephosphorylates insulin receptor substrate-1.
Sun Jun 01 00:00:00 UTC 2014
A novel inhibitor of the insulin/IGF signaling pathway protects from age-onset, neurodegeneration-linked proteotoxicity.
Aging cell
El-Ami T,Moll L,Carvalhal Marques F,Volovik Y,Reuveni H,Cohen E
44-816G was used in western blot to evaluate a novel insulin/IGF signaling pathway inhibitor for its protective effect on age-onset, neurodegeneration-linked proteotoxicity
Sat Feb 01 00:00:00 UTC 2014
Salicylate acutely stimulates 5'-AMP-activated protein kinase and insulin-independent glucose transport in rat skeletal muscles.
Biochemical and biophysical research communications
Serizawa Y,Oshima R,Yoshida M,Sakon I,Kitani K,Goto A,Tsuda S,Hayashi T
44-816G was used in western blot to investigate the relationship between 5'-AMP-activated protein kinase and salicylate in skeletal muscle.
Fri Oct 10 00:00:00 UTC 2014
The di-peptide Trp-His activates AMP-activated protein kinase and enhances glucose uptake independently of insulin in L6 myotubes.
FEBS open bio
Soga M,Ohashi A,Taniguchi M,Matsui T,Tsuda T
44-816G was used in western blot to test if Trp-His activates AMP-activated protein kinase to regulate the glucose transport system in skeletal muscle.
Mon Nov 10 00:00:00 UTC 2014
Leptin regulation of Hsp60 impacts hypothalamic insulin signaling.
The Journal of clinical investigation
Kleinridders A,Lauritzen HP,Ussar S,Christensen JH,Mori MA,Bross P,Kahn CR
Published figure using Phospho-IRS1 (Tyr612) polyclonal antibody (Product # 44-816G) in Western Blot
Fri Nov 01 00:00:00 UTC 2013
Resistance exercise, but not endurance exercise, induces IKKβ phosphorylation in human skeletal muscle of training-accustomed individuals.
Pflugers Archiv : European journal of physiology
Møller AB,Vendelbo MH,Rahbek SK,Clasen BF,Schjerling P,Vissing K,Jessen N
44-816G was used in western blot to study the IκB kinase complex, TSC, MAPK, upstream Akt activators, and gene expression of selected cytokines in skeletal muscles.
Sun Dec 01 00:00:00 UTC 2013
Variant NKX3.1 and Serum IGF-1: Investigation of Interaction in Prostate Cancer.
Genes & cancer
Muhlbradt E,Ma J,Severi G,Ortner E,Hayes V,Hoang HN,Stampfer M,Giles G,Pollak M,Gelmann EP
44-816G was used in western blot to report that variant NKX3. cannot induce IGFBP-3 expression and that the NKX3. genotype does not modify the association between serum IGF-I levels and prostate cancer risk.
Fri Nov 01 00:00:00 UTC 2013
Obesity in mice with adipocyte-specific deletion of clock component Arntl.
Nature medicine
Paschos GK,Ibrahim S,Song WL,Kunieda T,Grant G,Reyes TM,Bradfield CA,Vaughan CH,Eiden M,Masoodi M,Griffin JL,Wang F,Lawson JA,Fitzgerald GA
44-816G was used in western blot to characterize transgenic mice with an adipocyte-specific deletion of Arntl.
Sat Dec 01 00:00:00 UTC 2012
C1q/TNF-related protein-12 (CTRP12), a novel adipokine that improves insulin sensitivity and glycemic control in mouse models of obesity and diabetes.
The Journal of biological chemistry
Wei Z,Peterson JM,Lei X,Cebotaru L,Wolfgang MJ,Baldeviano GC,Wong GW
Fri Mar 23 00:00:00 UTC 2012
High IGF-IR activity in triple-negative breast cancer cell lines and tumorgrafts correlates with sensitivity to anti-IGF-IR therapy.
Clinical cancer research : an official journal of the American Association for Cancer Research
Litzenburger BC,Creighton CJ,Tsimelzon A,Chan BT,Hilsenbeck SG,Wang T,Carboni JM,Gottardis MM,Huang F,Chang JC,Lewis MT,Rimawi MF,Lee AV
44-816G was used in western blot to examine the IGF signature in breast cancer cells after treatment wit anti-IGF-I receptor or insulin receptor inhibitors.
Fri Apr 15 00:00:00 UTC 2011
Role of TAPP1 and TAPP2 adaptor binding to PtdIns(3,4)P2 in regulating insulin sensitivity defined by knock-in analysis.
The Biochemical journal
Wullschleger S,Wasserman DH,Gray A,Sakamoto K,Alessi DR
44-816G was used in Western Blotting to determine whether TAPP1 and TAPP2 play a role in regulating insulin sensitivity.
Tue Mar 01 00:00:00 UTC 2011
Myo1c regulates glucose uptake in mouse skeletal muscle.
The Journal of biological chemistry
Toyoda T,An D,Witczak CA,Koh HJ,Hirshman MF,Fujii N,Goodyear LJ
44-816G was used in western blot to investigate the expression profile and role of Myo1c in skeletal muscle
Fri Feb 11 00:00:00 UTC 2011
Myo1c regulates glucose uptake in mouse skeletal muscle.
The Journal of biological chemistry
Toyoda T,An D,Witczak CA,Koh HJ,Hirshman MF,Fujii N,Goodyear LJ
44-816G was used in western blot to investigate the expression profile and role of Myo1c in skeletal muscle
Fri Feb 11 00:00:00 UTC 2011
Compensatory insulin receptor (IR) activation on inhibition of insulin-like growth factor-1 receptor (IGF-1R): rationale for cotargeting IGF-1R and IR in cancer.
Molecular cancer therapeutics
Buck E,Gokhale PC,Koujak S,Brown E,Eyzaguirre A,Tao N,Rosenfeld-Franklin M,Lerner L,Chiu MI,Wild R,Epstein D,Pachter JA,Miglarese MR
Fri Oct 01 00:00:00 UTC 2010
NKX3.1 activates expression of insulin-like growth factor binding protein-3 to mediate insulin-like growth factor-I signaling and cell proliferation.
Cancer research
Muhlbradt E,Asatiani E,Ortner E,Wang A,Gelmann EP
44-816G was used in western blot to study the role and function of NKX3.1 in prostate cells
Sun Mar 15 00:00:00 UTC 2009
Insulin-like growth factor-I activation of Akt survival cascade in neuronal cells requires the presence of its cognate receptor in caveolae.
Experimental cell research
Lu X,Kambe F,Cao X,Yamauchi M,Seo H
Tue Jan 15 00:00:00 UTC 2008
Insulin-like growth factor-I activation of Akt survival cascade in neuronal cells requires the presence of its cognate receptor in caveolae.
Experimental cell research
Lu X,Kambe F,Cao X,Yamauchi M,Seo H
Tue Jan 15 00:00:00 UTC 2008
