Invitrogen

Phospho-JNK1 (Thr183) Polyclonal Antibody

Advanced Verification
1 Published Figure
1 Reference
View all (53) JNK1 antibodies

Promotion

View available promotion(s)

Promo code: {{promo.promoCode}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

PA5-37698

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:100
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Peptide sequence around phosphorylation site of threonine 183 (M-M-T(p)-P-Y) derived from Human SAPK/JNK.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2554306

Product Specific Information

A suggested positive control for Western blot is 293 cells; suggested positive control for IHC is human breast carcinoma.

Target Information

MAPK8 (JNK1) is activated by the presence of misfolded proteins in the endoplasmic reticulum. It is also a crucial mediator of insulin resistance and obesity. It belongs to the MAPK superfamily of stress-activated protein kinases. MAPKs are Serine-threonine protein kinases that are activated in response to a variety of extracellular stimuli, and mediate signal transduction from the cell surface to the nucleus. JNK is involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. JNK pathways are activated by stress and inflammatory signals. JNK is expressed as ten different isoforms due to differential mRNA splicing. The predominant forms are JNK1 and JNK2.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: c-Jun N-terminal kinase 1; FLJ12099; FLJ33785; JNK-46; JNK1 beta1 protein kinase; JNK3; JNK3A; JUN N-terminal kinase; MAP kinase 10; MAP kinase 8; MAPK 10; MAPK 8; MAPK10; MGC50974; mitogen activated protein kinase 8; Mitogen-activated protein kinase 8; mitogen-activated protein kinase 8 isoform JNK1 alpha1; mitogen-activated protein kinase 8 isoform JNK1 beta2; MK10; OTTHUMP00000019552; p493F12; p54 gamma; p54bSAPK; Phospho-JNK; PRKM10; protein kinase JNK1; protein kinase mitogen-activated 8; SAPK gamma; SAPK1c; stress-activated protein kinase 1; Stress-activated protein kinase 1c; Stress-activated protein kinase JNK1

View more View less

Gene Aliases: AI849689; JNK; JNK-46; JNK1; JNK1A2; JNK21B1/2; MAPK8; PRKM8; SAPK1; SAPK1C

View more View less

UniProt ID: (Human) P45983, (Rat) P49185, (Mouse) Q91Y86

View more View less

Entrez Gene ID: (Human) 5599, (Rat) 116554, (Mouse) 26419

View more View less

Function(s)
protein serine/threonine kinase activity JUN kinase activity protein binding ATP binding kinase activity enzyme binding histone deacetylase regulator activity histone deacetylase binding nucleotide binding protein kinase activity MAP kinase activity transferase activity transferase activity, transferring phosphorus-containing groups
Process(es)
protein phosphorylation response to stress JNK cascade JUN phosphorylation response to UV positive regulation of gene expression regulation of macroautophagy peptidyl-serine phosphorylation peptidyl-threonine phosphorylation regulation of histone deacetylation positive regulation of cyclase activity negative regulation of protein binding regulation of protein localization Fc-epsilon receptor signaling pathway regulation of circadian rhythm positive regulation of apoptotic process negative regulation of apoptotic process rhythmic process regulation of sequence-specific DNA binding transcription factor activity positive regulation of protein metabolic process cellular response to lipopolysaccharide cellular response to mechanical stimulus positive regulation of deacetylase activity positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway ossification regulation of transcription, DNA-templated inflammatory response response to osmotic stress signal transduction response to heat regulation of gene expression phosphorylation positive regulation of cell migration positive regulation of microtubule polymerization neuron projection development response to hydrogen peroxide positive regulation of DNA replication response to cadmium ion determination of dorsal identity cellular response to hydrogen peroxide cellular response to nitric oxide type B pancreatic cell apoptotic process neuronal stem cell population maintenance programmed necrotic cell death positive regulation of determination of dorsal identity positive regulation of apoptotic signaling pathway
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support