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Phospho-KIF1C (Ser1092) Antibody (PA5-105829) in ICC/IF
Immunofluorescent analysis of Phospho-KIF1C (Ser1092) in HepG2 cells. Samples were fixed with paraformaldehyde, permeabilized with 0.1% Triton X-100, blocked with 10% serum (45 min at 25°C), incubated with mouse anti-beta tubulin and Phospho-KIF1C (Ser1092) polyclonal antibody (Product # PA5-105829) using a dilution of 1:200 (1 hr, 37°C), and followed by goat anti-rabbit IgG Alexa Fluor 594 (red) and goat a... View More
Product Details
PA5-105829
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human KIF1C(Accession O43896), corresponding to amino acid residues around phosphorylated Ser1092.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
sequential chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2817228
Product Specific Information
Antibody detects endogenous levels of KIF1C only when phosphorylated at Ser1092.
Target Information
The kinesins constitute a large family of microtubule-dependent motor proteins, which are responsible for the distribution of numerous organelles, vesicles and macromolecular complexes throughout the cell. Individual kinesin members play crucial roles in cell division, intracellular transport, and membrane trafficking events including endocytosis and transcytosis. KIF1C is a member of the KIF1/Unc104 family of kinesin-like proteins, which are involved in the transport of mitochondria or synaptic vesicles in axons. Human KIF1C maps to chromosome 17p13 and encodes a predicted 1,103 amino acid protein with abundant expression in heart and skeletal muscle. Tyrosine phosphorylation is a putative regulator of KIF1C mediated retrograde transport of Golgi vesicles to the endoplasmic reticulum. KIF1C is capable of forming homodimers and can noncovalently associate with 14-3-3 beta, gamma, epsilon and zeta. In mouse macrophages, KIF1C is required for anthrax lethal toxin resistance.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: kinesin 1C; kinesin superfamily protein 1C; Kinesin-like protein KIF1C; Kinesin-like protein KIF1D; lethal factor toxin susceptibility 1; N-3 kinsin; spastic ataxia 2 (autosomal recessive)
Gene Aliases: B430105J22Rik; D11Bwg1349e; KIAA0706; KIF1C; Kif1d; LTXS1; SATX2; SAX2; SPAX2; SPG58
UniProt ID: (Human) O43896, (Rat) O35787, (Mouse) O35071
Entrez Gene ID: (Human) 10749, (Rat) 113886, (Mouse) 16562
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