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Invitrogen
Phospho-LRP6 (Ser1490) Polyclonal Antibody
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Phospho-LRP6 (Ser1490) Antibody (PA5-117266) in WB
Western blot analysis of Phospho-LRP6 (Ser1490) in extracts of HeLa cells. Samples were incubated with Phospho-LRP6 (Ser1490) Polyclonal antibody (Product # PA5-117266) using a dilution of 1:500, followed by HRP Goat Anti-Rabbit IgG (H+L) secondary antibody at a dilution of 1:10,000. HeLa cells were treated by Calyculin A (100 nM) at 37°C for 30 minutes after serum-starvation overnight. Lysates/proteins: 25... View More
Product Details
PA5-117266
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic phosphorylated peptide around S1490 of human LRP6 (NP_0023272)
Conjugate
Form
Liquid
Concentration
0.429 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.01% thimerosal
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
RRID
AB_2901896
Product Specific Information
Positive Samples: HeLa
Immunogen sequence: PPSPA
Target Information
LRP6 is essential for the Wnt/beta catenin signaling pathway, probably by acting as a coreceptor together with Frizzled for Wnt. It is a specific, high-affinity receptor for DKK1 and DKK2, but not DKK3. The interaction with DKK1 blocks LRP6-mediated Wnt/beta catenin signaling via LRP6 removal via Kremen proteins-mediated endocytosis.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ90062; FLJ90421; low density lipoprotein receptor-related protein 6; Low-density lipoprotein receptor-related protein 6; lpr6; LRP-6
Gene Aliases: ADCAD2; LRP6; STHAG7
UniProt ID: (Human) O75581
Entrez Gene ID: (Human) 4040
low-density lipoprotein receptor activity
receptor binding
frizzled binding
protein binding
Wnt-protein binding
kinase inhibitor activity
toxin transporter activity
apolipoprotein binding
identical protein binding
protein homodimerization activity
Wnt-activated receptor activity
coreceptor activity involved in Wnt signaling pathway
coreceptor activity involved in canonical Wnt signaling pathway
neural tube closure
negative regulation of protein phosphorylation
pericardium morphogenesis
negative regulation of protein kinase activity
positive regulation of cytosolic calcium ion concentration
chemical synaptic transmission
embryonic pattern specification
neural crest formation
neural crest cell differentiation
Wnt signaling pathway
single organismal cell-cell adhesion
cerebellum morphogenesis
thalamus development
cerebral cortex development
midbrain-hindbrain boundary development
negative regulation of smooth muscle cell apoptotic process
external genitalia morphogenesis
odontogenesis of dentin-containing tooth
response to peptide hormone
Wnt signaling pathway involved in dorsal/ventral axis specification
canonical Wnt signaling pathway involved in neural crest cell differentiation
canonical Wnt signaling pathway involved in regulation of cell proliferation
positive regulation of cell cycle
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of sequence-specific DNA binding transcription factor activity
palate development
convergent extension
embryonic retina morphogenesis in camera-type eye
canonical Wnt signaling pathway
face morphogenesis
trachea cartilage morphogenesis
cellular response to cholesterol
dopaminergic neuron differentiation
negative regulation of protein serine/threonine kinase activity
protein localization to plasma membrane
primitive streak formation
negative regulation of canonical Wnt signaling pathway
receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport
Wnt signaling pathway involved in somitogenesis
axis elongation involved in somitogenesis
positive regulation of canonical Wnt signaling pathway
toxin transport
beta-catenin destruction complex disassembly
midbrain dopaminergic neuron differentiation
Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation
positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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