Invitrogen

Phospho-LRRK2 (Ser935) Recombinant Rabbit Monoclonal Antibody (4J10Z7)

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

MA5-55186

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

ELISA (ELISA)

1 µg/mL
-
Product Specifications

Species Reactivity

Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

4J10Z7

Immunogen

A synthetic phosphorylated peptide around S935 of human LRRK2.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.6 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 50% glycerol, 0.05% BSA

Contains

0.02% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

RRID

AB_3667432

Product Specific Information

Immunogen Sequence: SNSLG

Target Information

LRRK2 is a multidomain protein that includes a kinase domain, a GTPase domain, and a leucine-rich repeat (LRR) domain. Mutations in LRRK2 have been associated with Parkinson's disease. LRRK2 is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: BC 300-268; DKFZp434H2111; FLJ45829; Leucine-rich repeat serine/threonine-protein kinase 2; LRR kinase 2; LRRK 2; LRRK-2

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Gene Aliases: 4921513O20Rik; 9330188B09Rik; AW561911; cI-46; D630001M17Rik; Gm927; Lrrk2

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UniProt ID: (Mouse) Q5S006

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Entrez Gene ID: (Mouse) 66725, (Rat) 300160

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Function(s)
SNARE binding nucleotide binding glycoprotein binding actin binding GTPase activity protein kinase activity protein serine/threonine kinase activity MAP kinase kinase activity GTPase activator activity protein binding ATP binding GTP binding tubulin binding kinase activity transferase activity transferase activity, transferring phosphorus-containing groups Rho GTPase binding syntaxin-1 binding clathrin binding GTP-dependent protein kinase activity peroxidase inhibitor activity identical protein binding protein homodimerization activity ion channel binding protein kinase A binding molecular_function
Process(es)
MAPK cascade activation of MAPKK activity activation of MAPK activity negative regulation of protein phosphorylation positive regulation of protein phosphorylation protein phosphorylation endocytosis autophagy response to oxidative stress mitochondrion organization Golgi organization small GTPase mediated signal transduction neuromuscular junction development determination of adult lifespan positive regulation of autophagy regulation of protein kinase A signaling negative regulation of protein processing regulation of neuron maturation phosphorylation peptidyl-serine phosphorylation peptidyl-threonine phosphorylation olfactory bulb development tangential migration from the subventricular zone to the olfactory bulb cell differentiation positive regulation of protein ubiquitination negative regulation of protein binding positive regulation of protein binding positive regulation of proteasomal ubiquitin-dependent protein catabolic process negative regulation of GTPase activity cellular response to oxidative stress cellular protein localization intracellular signal transduction regulation of kidney size exploration behavior locomotory exploration behavior synaptic vesicle recycling regulation of locomotion regulation of membrane potential positive regulation of programmed cell death positive regulation of GTPase activity GTP metabolic process protein autophosphorylation intracellular distribution of mitochondria neuron projection morphogenesis mitochondrion localization regulation of mitochondrial depolarization regulation of synaptic transmission, glutamatergic excitatory postsynaptic potential regulation of dopamine receptor signaling pathway positive regulation of dopamine receptor signaling pathway regulation of dendritic spine morphogenesis neuron death cellular response to manganese ion reactive oxygen species metabolic process regulation of neuron death negative regulation of neuron death negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway positive regulation of protein autoubiquitination regulation of neuroblast proliferation regulation of synaptic vesicle transport negative regulation of thioredoxin peroxidase activity by peptidyl-threonine phosphorylation negative regulation of hydrogen peroxide-induced cell death negative regulation of protein targeting to mitochondrion cellular response to dopamine regulation of branching morphogenesis of a nerve regulation of synaptic vesicle exocytosis negative regulation of peroxidase activity cellular response to organic cyclic compound
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