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Invitrogen
Phospho-LTK/ALK (Tyr672, Tyr1278) Polyclonal Antibody
FIGURE: 1 / 1
Phospho-LTK/ALK (Tyr672, Tyr1278) Antibody (PA5-99574) in WB
Western blot analysis of Phospho-LTK/ALK (Tyr672, Tyr1278) in myeloma cells heat-shock treated (left lane: treated with blocking peptide). Samples were incubated with Phospho-LTK/ALK (Tyr672, Tyr1278) polyclonal antibody (Product # PA5-99574).
Product Details
PA5-99574
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human LTK(Accession P29376), corresponding to amino acid residues around phosphorylated Tyr672.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
sequential chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
RRID
AB_2818507
Product Specific Information
Antibody detects endogenous levels of LTK/ALK only when phosphorylated at Tyr672/Tyr1278.
Target Information
The protein encoded by this gene is a member of the ros/insulin receptor family of tyrosine kinases. Tyrosine-specific phosphorylation of proteins is a key to the control of diverse pathways leading to cell growth and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ALK tyrosine kinase receptor; Anaplastic lymphoma kinase; CD246; CD246 antigen; leukocyte receptor tyrosine kinase; Leukocyte tyrosine kinase receptor; mutant anaplastic lymphoma kinase; npm-alk; Protein tyrosine kinase 1; tyrosine kinase-1
Gene Aliases: ALK; CD246; LTK; NBLST3; Tcrz; TYK1
UniProt ID: (Human) Q9UM73, (Mouse) P97793, (Human) P29376, (Mouse) P08923
Entrez Gene ID: (Human) 238, (Mouse) 11682, (Human) 4058, (Mouse) 17005
NF-kappaB-inducing kinase activity
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
protein binding
ATP binding
identical protein binding
nucleotide binding
protein kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
protein phosphorylation
signal transduction
transmembrane receptor protein tyrosine kinase signaling pathway
cell proliferation
positive regulation of cardiac muscle cell apoptotic process
positive regulation of neuron projection development
phosphatidylinositol 3-kinase signaling
peptidyl-tyrosine phosphorylation
negative regulation of apoptotic process
cellular response to retinoic acid
activation of MAPK activity
nervous system development
phosphorylation
protein autophosphorylation
neuron development
NIK/NF-kappaB signaling
regulation of apoptotic process
positive regulation of NF-kappaB transcription factor activity
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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