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Invitrogen
Phospho-MEK3/MEK6 (Ser189, Ser207) Polyclonal Antibody
FIGURE: 1 / 2
Phospho-MEK3/MEK6 (Ser189, Ser207) Antibody (PA5-17887) in WB
Western blot was performed using Anti-Phospho-MEK3/MEK6 (Ser189, Ser207) Polyclonal Antibody(Product # PA5-17887) and a 39 kDa and 37 kDa bands corresponding to Phospho-MEK3/MEK6 (Ser189, Ser207) were observed in A549 cell line treated with Anisomycin and not treated with PMA. Whole Cell Extract-WCL (30 µg lysate) of A549 (Lane 1), A549 treated with 25 µg/mL Anisomycin for 30 minutes (Lane 2) and A549 treat... View More
Product Details
PA5-17887
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic phosphopeptide corresponding to residues around pSer189/207 of human MKK3
Conjugate
Form
Liquid
Concentration
40 µg/mL
Purification
Antigen affinity chromatography
Storage buffer
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_10980081
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
This gene encodes a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases, act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, this gene is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Dual specificity mitogen-activated protein kinase kinase 3; Dual specificity mitogen-activated protein kinase kinase 6; MAP kinase kinase 3; MAP kinase kinase 6; MAPK/ERK kinase 3; MAPK/ERK kinase 6; MAPKK 3; MAPKK 6; MEK 3; MEK 6; mitogen activated protein kinase kinase 3; mitogen activated protein kinase kinase 6; OTTHUMP00000166044; protein kinase, mitogen activated, kinase 6; protein kinase, mitogen-activated, kinase 3; protein kinase, mitogen-activated, kinase 6 (MAP kinase kinase 6); SAPK kinase 2; SAPK kinase 3; SAPKK3; Stress-activated protein kinase kinase 2; Stress-activated protein kinase kinase 3
Gene Aliases: AW212142; MAP2K3; MAP2K6; MAPKK3; MAPKK6; MEK3; MEK6; MKK3; MKK6; mMKK3b; PRKMK3; PRKMK6; SAPKK-2; SAPKK-3; SAPKK2; SAPKK3; SKK2; SKK3
UniProt ID: (Human) P46734, (Human) P52564, (Mouse) O09110, (Mouse) P70236
Entrez Gene ID: (Human) 5606, (Human) 5608, (Mouse) 26397, (Rat) 303200, (Mouse) 26399, (Rat) 114495
receptor signaling protein serine/threonine kinase activity
MAP kinase kinase activity
protein tyrosine kinase activity
protein binding
ATP binding
protein kinase binding
nucleotide binding
protein kinase activity
protein serine/threonine kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
MAPK cascade
activation of MAPK activity
protein phosphorylation
inflammatory response
regulation of mitotic cell cycle
phosphorylation
stress-activated protein kinase signaling cascade
regulation of cytokine biosynthetic process
regulation of apoptotic process
positive regulation of protein kinase activity
positive regulation of transcription, DNA-templated
cardiac muscle contraction
signal transduction
peptidyl-tyrosine phosphorylation
proteolysis in other organism
positive regulation of protein phosphorylation
response to ischemia
heart development
positive regulation of nitric-oxide synthase biosynthetic process
cellular response to lipopolysaccharide
cellular response to sorbitol
transcription, DNA-templated
regulation of transcription, DNA-templated
apoptotic process
DNA damage induced protein phosphorylation
cell cycle arrest
ovulation cycle process
positive regulation of prostaglandin secretion
response to drug
positive regulation of apoptotic process
nucleotide-binding oligomerization domain containing signaling pathway
regulation of signal transduction
intracellular signal transduction
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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