Search Thermo Fisher Scientific
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Invitrogen
Phospho-MLK1/MLK2 (Thr312, Thr266) Polyclonal Antibody
Promotion
View available promotion(s)
Promo code: {{promo.promoCode}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
FIGURE: 1 / 1
Phospho-MLK1/MLK2 (Thr312, Thr266) Antibody (PA5-37818) in IHC (P)
Immunohistochemical analysis of Phospho-MLK1/MLK2 (Thr312, Thr266) in paraffin-embedded Human brain tissue using Phospho-MLK1/MLK2 (Thr312, Thr266) Polyclonal Antibody (Product # PA5-37818) (left) or the same antibody preincubated with blocking peptide (right).
Product Details
PA5-37818
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Peptide sequence around phosphorylation site of threonine 312/266(A-G-T(p)-Y-A) derived from Human MLK1/2.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2554426
Product Specific Information
A suggested positive control for IHC is human brain tissue.
Target Information
MLK is a member of the serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phoshorylated, and thus activated by JNK kinases. This kinase functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor (NGF) induced neuronal apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: mitogen activated protein kinase kinase kinase 9; Mitogen-activated protein kinase kinase kinase 10; Mitogen-activated protein kinase kinase kinase 9; Mixed lineage kinase 1; mixed lineage kinase 1 (tyr and ser/thr specificity); Mixed lineage kinase 2; MKN28 derived nonreceptor_type; MKN28 derived nonreceptor_type serine/threonine kinase; MKN28 kinase; Protein kinase MST; serine/threonine kinase
Gene Aliases: BC028668; BC046514; E130314H24Rik; MAP3K10; MAP3K9; MEKK10; MEKK9; MLK1; MLK2; MST; PRKE1
UniProt ID: (Human) Q02779, (Human) P80192, (Mouse) Q66L42, (Mouse) Q3U1V8
Entrez Gene ID: (Human) 4294, (Human) 4293, (Mouse) 269881, (Mouse) 338372
transcription corepressor activity
protein kinase activity
protein serine/threonine kinase activity
JUN kinase kinase kinase activity
ATP binding
protein homodimerization activity
bHLH transcription factor binding
MAP kinase kinase activity
protein binding
nucleotide binding
MAP kinase kinase kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
protein tyrosine kinase activity
apoptotic process
signal transduction
smoothened signaling pathway
JNK cascade
activation of JNKK activity
activation of JUN kinase activity
peptidyl-serine phosphorylation
peptidyl-threonine phosphorylation
positive regulation of apoptotic process
negative regulation of sequence-specific DNA binding transcription factor activity
positive regulation of JUN kinase activity
negative regulation of transcription, DNA-templated
positive regulation of JNK cascade
protein autophosphorylation
transcription, DNA-templated
regulation of transcription, DNA-templated
protein phosphorylation
cell death
phosphorylation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support