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Invitrogen
Phospho-MSK1 (Thr581) Recombinant Rabbit Monoclonal Antibody (MSK1T581-A5), PE
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FIGURE: 1 / 1
Phospho-MSK1 (Thr581) Antibody (MA5-37290) in Flow
Flow cytometry of Phospho-MSK1 (Thr581) using COS7 cells. Samples were incubated in monoclonal Phospho-MSK1 (Thr581) antibody (Product # MA5-37290). Images correspond with the following conditions: unstained, untreated (blue), untreated (red), treated with TPA/CalA (green).
Product Details
MA5-37290
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG, kappa
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
MSK1T581-A5
Immunogen
A synthetic phospho-peptide corresponding to residues surrounding Thr581 of human phospho MSK1.
Conjugate
Excitation/Emission Max
565/576 nm
View spectra
Form
Liquid
Purification
Protein A/G
Storage buffer
PBS with 0.20% BSA
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2897224
Target Information
RPS6KA5 (MSK1) is a serine/threonine protein kinase that is essential for the regulation of various cellular processes. RPS6KA5 is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factors RELA, STAT3 and ETV1/ER81, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF and upon glucocorticoid, associates in the cytoplasm with the glucocorticoid receptor NR3C1 and contributes to RELA inhibition and repression of inflammatory gene expression. In skeletal myoblasts is required for phosphorylation of RELA at 'Ser-276' during oxidative stress. In erythropoietin-stimulated cells, is necessary for the 'Ser-727' phosphorylation of STAT3 and regulation of its transcriptional potential.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 90 kDa ribosomal protein S6 kinase 5; kinase MSK1; KS6A5; mitogen and stress-activated protein kinase 1; Nuclear mitogen- and stress-activated protein kinase 1; Ribosomal protein S6 kinase alpha-5; ribosomal protein S6 kinase, 90kDa, polypeptide 5; RLSK; RSK-like protein kinase; RSKL; S6K-alpha-5
Gene Aliases: 3110005L17Rik; 6330404E13Rik; AI854034; MSK1; MSPK1; RLPK; RPS6KA5
UniProt ID: (Human) O75582, (Mouse) Q8C050
Entrez Gene ID: (Human) 9252, (Mouse) 73086, (Rat) 314384
regulation of transcription, DNA-templated
protein phosphorylation
inflammatory response
phosphorylation
histone phosphorylation
positive regulation of histone phosphorylation
positive regulation of histone acetylation
intracellular signal transduction
histone H3-S10 phosphorylation
histone H3-S28 phosphorylation
histone H2A-S1 phosphorylation
negative regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of NF-kappaB transcription factor activity
interleukin-1-mediated signaling pathway
negative regulation of cytokine production
stimulatory C-type lectin receptor signaling pathway
epidermal growth factor receptor signaling pathway
axon guidance
positive regulation of CREB transcription factor activity
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