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Phospho-MYL9/MYL12 (Ser20) Antibody (PA1-26470) in IHC (P)
Immunohistochemistry analysis of Phospho-MYL9/MYL12 (Ser20) was performed in a variety of tissues including multi-human, multi-brain and multi-cancer slides using Phospho-MYL9/MYL12 (Ser20) Polyclonal Antibody (Product # PA1-26470) at 2.5 µg/mL. This image shows strong staining of both vascular and myometrial smooth muscle cells of the uterus. Tissue was formalin-fixed and paraffin embedded. The image shows... View More
Product Details
PA1-26470
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Human Myosin Light Chain phospho peptide corresponding to a region near the amino terminus of the human smooth/non-muscle form of myosin regulatory light chain conjugated to KLH.
Conjugate
Form
Liquid
Concentration
1.19 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 0.15M NaCl
Contains
0.01% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_795761
Product Specific Information
Recommended positive controls: Cardiac myocytes.
PA1-26470 is expected to cross react with all mammals and birds due to 100% sequence homology.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Myosin regulatory light polypeptide 9 is a highly conserved, ubiquitously expressed protein that in humans is encoded by the MYL9 gene. Myosin, a structural component of muscle, are hexameric proteins consisting of two heavy chains and four light chains, including a single pair of nonphosphorylatable light chain subunits and another pair of phosphorylatable light chain subunits.The protein encoded by this gene is a myosin light chain that may regulate muscle contraction by modulating the ATPase activity of myosin heads. Myosin light chain (Myl) 9 and Myl12 are new functional ligands for CD69. Blockade of CD69-Myl9/12 interactio ameliorates allergic airway inflammation in ovalbumin-induced and house dust mite-induced mouse models of asthma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 20 kDa myosin light chain; brain specific myosin regulatory light chain; Epididymis secretory protein Li 24; HEL-S-24; LC20; MLC-2; MLC-2A; MLC-2B; MLC-2C; MLC20; myosin light chain, regulatory B; myosin light chain, regulatory B-like; myosin light chain, regulatory C; myosin regulatory light chain 1; Myosin regulatory light chain 12A; Myosin regulatory light chain 12B; myosin regulatory light chain 2; Myosin regulatory light chain 2, nonsarcomeric; Myosin regulatory light chain 2, smooth muscle isoform; Myosin regulatory light chain 2-B, smooth muscle isoform; Myosin regulatory light chain 20 kDa; myosin regulatory light chain 3; Myosin regulatory light chain 9; Myosin regulatory light chain MRLC1; Myosin regulatory light chain MRLC2; Myosin regulatory light chain MRLC3; Myosin regulatory light polypeptide 9; Myosin RLC; myosin, light chain 12A, regulatory, non-sarcomeric; myosin, light chain 12B, regulatory; myosin, light chain 9, regulatory; myosin, light polypeptide 9, regulatory; myosin, light polypeptide, regulatory, non-sarcomeric (20kD); NMDA receptor-interacting protein; SHUJUN-1
Gene Aliases: 1500001M02Rik; 2900073G15Rik; AI327049; AI838292; C77744; C80200; HEL-S-24; LC20; MLC-2B; MLC-2C; MLC-B; MLC2; MLC20; MLCB; MRCL3; MRLC1; MRLC2; MRLC3; MYL12A; MYL12B; MYL2B; MYL9; MYLC2B; Mylc2c; MYRL2; RLC; RLC-B; RLC-C
UniProt ID: (Human) P19105, (Human) O14950, (Human) P24844, (Mouse) Q3THE2, (Mouse) Q9CQ19
Entrez Gene ID: (Human) 10627, (Human) 103910, (Human) 10398, (Mouse) 67268, (Mouse) 67938, (Mouse) 98932
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