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Invitrogen
Phospho-NDRG1 (Thr346) Polyclonal Antibody
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.jpg?time=20250104 "Phospho-NDRG1 (Thr346) Antibody in Western Blot (WB)")
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.jpg?time=20250104?time=20250104 "Phospho-NDRG1 (Thr346) Antibody (PA5-17064) in WB")
Product Details
PA5-17064
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic phosphopeptide corresponding to residues surrounding pThr346 of NDRG1
Conjugate
Form
Liquid
Purification
Protein A
Storage buffer
0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/mL BSA, 50% glycerol
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_10984103
Product Specific Information
It is not recommended to aliquot this antibody.
Target Information
NDRG1 is a 394 amino acid cytoplasmic protein belonging to the NDRG family. It interacts with APO A-I and A-II and plays a role in HDL-mediated cholesterol transport, stress responses, hormone responses, cell growth and differentiation. Its defect causes Charcot-Marie-Tooth disease type 4D (CMT4D) that is characterized by reduced nerve conduction velocities, segmental demyelination and remyelination with onion bulb formations on nerve biopsy, slowly progressive distal muscle atrophy and weakness, absent deep tendon reflexes and hollow feet. NDRG1 plays a growth inhibitory role and serves as a marker of differentiation. It is expressed in placental membranes, prostate, kidney, small intestine, ovary tissues, colon and the cells that border the lumen.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Differentiation-related gene 1 protein; DRG-1; N-myc downstream regulated 1; N-myc downstream regulated gene 1; N-myc downstream-regulated gene 1 protein; Nickel-specific induction protein Cap43; Protein Ndr1; Protein NDRG1; protein regulated by oxygen-1; Reducing agents and tunicamycin-responsive protein; Rit42; RTP
Gene Aliases: CAP43; CMT4D; DRG-1; DRG1; GC4; HMSNL; NDR1; NDRG1; Ndrl; NMSL; PROXY1; RIT42; RTP; TARG1; TDD5
UniProt ID: (Human) Q92597, (Mouse) Q62433, (Rat) Q6JE36
Entrez Gene ID: (Human) 10397, (Mouse) 17988, (Rat) 299923
signal transduction
peripheral nervous system myelin maintenance
mast cell activation
positive regulation of spindle checkpoint
DNA damage response, signal transduction by p53 class mediator
cellular response to hypoxia
negative regulation of cell proliferation
response to metal ion
regulation of apoptotic process
cell-cell adhesion
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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